Protein Alignment HTR1B and Oamb

DIOPT Version :10

• Sequence 1: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 573
• Identity: 139/573 - (24%)
• Similarity: 200/573 - (34%)
• Gaps: 238/573 - (41%)

Human    47 PWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTV 111
            |..::.:.:|..|.:.....|..|||.|:.:.||.:..|:.|.:|||.||||.:.|:|.|..:.|
  Fly    18 PANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEV 82

Human   112 TGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVF 176
            ...|..|.:.|..||:.|:..||||||:||.|:||||.|:|..|.|.:..:.|:|..:||.:||.
  Fly    83 FKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVL 147

Human   177 SISISLPPFF-WRQAKA------------------------------------------------ 192
            |..|..||.. |:..||
  Fly   148 SFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIG 212

Human   193 -----------------------------------------------EEEVS------------- 197
                                                           |.|:.
  Fly   213 NGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQ 277

Human   198 --------ECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIY------VEARSRILKQTPNRTG 248
                    :|.:..|. .|.:||.:|:||.|..:::..|.|||      ..|.::..|.|....|
  Fly   278 TISGSCPWKCELTNDR-GYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKG 341

Human   249 -------KRLT---------RAQLITDSPGST-SSVTSINSRVPD-------------------- 276
                   :|||         ..|....|.||| |:.|::.:..|:
  Fly   342 IGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISV 406

Human   277 -VPS------------------ESG------------------SPVYVNQVK--------VRVSD 296
             .||                  :||                  |.:|..|.:        ::|..
  Fly   407 SYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGK 471

Human   297 ALLE-------------------KKKLMAAR-----------ERKATKTLGIILGAFIVCWLPFF 331
            .|.|                   ..|.|..|           |.||.|||.||:|.||.||.|||
  Fly   472 GLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFF 536

Human   332 IISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
            .:.::.|.|:| |...| :|....||||.||.:||:||.:.::||:.||.::|
  Fly   537 TMYIIRPFCQD-CVDPL-LFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	136/567 (24%)
		TM helix 1	51..77	CDD:320455	7/25 (28%)
		TM helix 2	84..110	CDD:320455	12/25 (48%)
		TM helix 3	122..152	CDD:320455	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	10/23 (43%)
		TM helix 5	205..234	CDD:320455	11/34 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		9/61 (15%)
		TM helix 6	307..337	CDD:320455	17/40 (43%)
		TM helix 7	348..373	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		2/3 (67%)
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	135/564 (24%)
		TM helix 1	22..48	CDD:320191	7/25 (28%)
		TM helix 2	55..81	CDD:320191	12/25 (48%)
		TM helix 3	93..123	CDD:320191	18/29 (62%)
		TM helix 4	135..158	CDD:320191	10/22 (45%)
		TM helix 5	292..321	CDD:320191	12/29 (41%)
		TM helix 6	512..542	CDD:320191	16/29 (55%)
		TM helix 7	551..576	CDD:320191	12/25 (48%)