Protein Alignment HTR1B and 5-HT7

DIOPT Version :10

• Sequence 1: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 418
• Identity: 144/418 - (34%)
• Similarity: 220/418 - (52%)
• Gaps: 70/418 - (16%)

Human    18 TWVPQANLSSAP--SQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKL 80
            |.||   ||..|  .:..:|.:::.....|    :.:.::|.::.|.|.:.|..|...|...|||
  Fly   136 TLVP---LSDTPLLLEEFAAGEFVLPPLTS----IFVSIVLLIVILGTVVGNVLVCIAVCMVRKL 193

Human    81 HTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIAL 145
            ..|.|||:.|||::||.|::||||::.:|.|..:|..|.::||.|:|.|:.|||||||:||.|::
  Fly   194 RRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISV 258

Human   146 DRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSE--CVVNTDHILY 208
            |||.|||..:||..||||:|..:.:.:||:.:..|||||......:.|:|..:  |.| ..:..|
  Fly   259 DRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTV-CQNFAY 322

Human   209 TVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSP--------GSTS 265
            .:|:|:|:||.|..:::.:|.:|:..||..:|::  .|....|.:|...|.||        |.|.
  Fly   323 QIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEE--KRAQTHLQQALNGTGSPSAPQAPPLGHTE 385

Human   266 SVTSIN-SRVPDVPSES--------------------------------GSPVYVNQVKVRVSDA 297
            ..:|.| .|...|.:.|                                |||.:
  Fly   386 LASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHH----------- 439

Human   298 LLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNS 362
              :|.:...|:|:||:.|||||:.||.||||||||::|:.|.  :......::...|.||||.||
  Fly   440 --KKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLGYANS 500

Human   363 LINPIIYTMSNEDFKQAFHKLIRFKCTS 390
            |:|||||...|.||::.|.:::.|:|:|
  Fly   501 LLNPIIYATLNRDFRKPFQEILYFRCSS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	132/376 (35%)
		TM helix 1	51..77	CDD:320455	6/25 (24%)
		TM helix 2	84..110	CDD:320455	13/25 (52%)
		TM helix 3	122..152	CDD:320455	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	8/22 (36%)
		TM helix 5	205..234	CDD:320455	9/28 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		8/30 (27%)
		TM helix 6	307..337	CDD:320455	20/29 (69%)
		TM helix 7	348..373	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		3/3 (100%)
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	132/372 (35%)
		TM helix 1	164..190	CDD:320452	6/25 (24%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	9/28 (32%)
		TM helix 6	447..477	CDD:320452	20/29 (69%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)