Protein Alignment HTR1B and Oct-TyrR

DIOPT Version :10

• Sequence 1: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 149/530 - (28%)
• Similarity: 234/530 - (44%)
• Gaps: 170/530 - (32%)

Human    23 ANLSSAPSQNCSAKD----------YIYQDSISLP-WKVLL-VMLLALITLATTLSNAFVIATVY 75
            |.||:|.:...||.:          .|....:::| |:.|| .::|::|.:.|.:.|..||.:|:
  Fly    71 AALSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVF 135

Human    76 RTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHL 140
            ..:.|....|:.|.||||.||.|::||:|.:..|::.|||..|..:|..||:.|:.|||:|||:|
  Fly   136 TYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNL 200

Human   141 CVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQAKAE-EEVSECVVNT 203
            |.|||||||||||.:.|:.|||..|..::|:.||:.|:.||.||.. |.....| ...:.|.: |
  Fly   201 CAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATPCEL-T 264

Human   204 DHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRI-------------LKQT------------ 243
            ....|.:||::|:|:.|..::..:|..|:|..|.|:             ||.|
  Fly   265 SQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVA 329

Human   244 PNRTGKR-----------LTRAQ----LITDSPGSTSSVT------------------------- 268
            .:.:|.:           ..|||    :|.:...|.||.|
  Fly   330 ASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVL 394

Human   269 ---SINSRVPD----------------------------------------------------VP 278
               |..::..|                                                    :.
  Fly   395 VKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEIS 459

Human   279 SESGS------PVYVNQVKVR----------------------------VSDALLEKKKLMAARE 309
            :||||      .|.|.|...:                            |:..:.||:|:..::|
  Fly   460 TESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKE 524

Human   310 RKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNE 374
            |:|.:|||||:|.|::||||||::.:::|.|:..|..: ...:|.|||||:||.:||:|||:.|.
  Fly   525 RRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTN-KFKNFITWLGYINSGLNPVIYTIFNL 588

Human   375 DFKQAFHKLI 384
            |:::||.:|:
  Fly   589 DYRRAFKRLL 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	139/491 (28%)
		TM helix 1	51..77	CDD:320455	9/26 (35%)
		TM helix 2	84..110	CDD:320455	12/25 (48%)
		TM helix 3	122..152	CDD:320455	20/29 (69%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	9/23 (39%)
		TM helix 5	205..234	CDD:320455	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		6/101 (6%)
		TM helix 6	307..337	CDD:320455	16/29 (55%)
		TM helix 7	348..373	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		2/3 (67%)
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	75/184 (41%)
		TM helix 1	111..137	CDD:320188	8/25 (32%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	20/29 (69%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	8/27 (30%)
		7tm_GPCRs	<519..594	CDD:475119	34/75 (45%)
		TM helix 6	528..550	CDD:410628	13/21 (62%)
		TM helix 7	562..587	CDD:410628	13/25 (52%)