Protein Alignment HTR1B and TyrRII

DIOPT Version :10

• Sequence 1: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 142/520 - (27%)
• Similarity: 203/520 - (39%)
• Gaps: 179/520 - (34%)

Human    29 PSQNCSAKDYIYQDSISLPW-KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLA 92
            ||.|    .|:    :|:.| |.|.|.:..:|.|.|.:.|..||..|..||:|.|..|..:.:||
  Fly    61 PSMN----SYL----VSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLA 117

Human    93 VTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEY 157
            :||.||...|||.|.:..:||.|..|.::||.|:|.||..|:.|||.||.|:||||.|:|..:.|
  Fly   118 ITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTY 182

Human   158 SAKRTPKR-AAVMIALVWVFSISISLPPFF-WRQ-AKAEEEVSECVVNTDHILYTVYSTVGAFYF 219
            |.||..|| |.:||.:||:.::||:.||:. |.: .:.:.|..:|..|.:. .|.|:|.:|:|:.
  Fly   183 SKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNK-GYVVFSAMGSFFI 246

Human   220 PTLLLIALY---GRIYVEARSRIL------------------------------KQTPNRTGKRL 251
            |..:::.:|   |.:....|.||:                              |..|||  |..
  Fly   247 PLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNR--KSR 309

Human   252 TRAQLITDSP----------GSTSSVTSINSRVPDVPSESGS-------------------PVYV 287
            .|...:.|.|          |..|||..  |:.....|.:|:                   |.:.
  Fly   310 WRFNSLHDPPPSAATNAAAKGHQSSVKC--SKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFY 372

Human   288 NQVKV-RVSD-----------------------------------------------------AL 298
            ..|:| |:|.                                                     ||
  Fly   373 ELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVAL 437

Human   299 LEKKKLMA---------------------------------------------ARERKATKTLGI 318
            ...:||.|                                             .|:.|..|||.|
  Fly   438 ETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTI 502

Human   319 ILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL 383
            ::|..|.||||||:..|::|...........:|. |||:|::|..|||.||...|.||:.||.:|
  Fly   503 VMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRL 566

Human   384  383
              Fly   567  566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	134/498 (27%)
		TM helix 1	51..77	CDD:320455	9/25 (36%)
		TM helix 2	84..110	CDD:320455	11/25 (44%)
		TM helix 3	122..152	CDD:320455	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	11/24 (46%)
		TM helix 5	205..234	CDD:320455	8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		8/31 (26%)
		TM helix 6	307..337	CDD:320455	15/29 (52%)
		TM helix 7	348..373	CDD:320455	11/24 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		2/3 (67%)
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	75/192 (39%)
		TM helix 1	78..101	CDD:410628	8/22 (36%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	12/21 (57%)
		TM helix 4	194..210	CDD:410628	6/15 (40%)
		TM helix 5	233..256	CDD:410628	6/23 (26%)
		7tm_GPCRs	<491..563	CDD:475119	30/72 (42%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	11/25 (44%)