Protein Alignment HTR1B and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Alignment Length: 595
• Identity: 122/595 - (20%)
• Similarity: 188/595 - (31%)
• Gaps: 274/595 - (46%)

Human    52 LVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWT 116
            |.:.:.....|..|.|..|...|...|||....||.:.|||:.|||||:.|||:..:....|.|.
  Fly   288 LFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWP 352

Human   117 LGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISIS 181
            ||...|:.:::.|:..|::||||:|.|:|.||..|.:.:....:.|.:...:.||:|||.::.:|
  Fly   353 LGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVS 417

Human   182 --------------LPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYG--- 229
                          :|           |.:.||:|  :..:.|:.::.|||.|.|:::..|.
  Fly   418 SSITVLGLVNEKNIMP-----------EPNICVIN--NRAFFVFGSLVAFYIPMLMMVTTYALTI 469

Human   230 ----------------------------------------------------------------- 229
                                                                             
  Fly   470 PLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGE 534

Human   230 ---------RIYVEARSRILKQTPNRT------------------------GKRLTRA------- 254
                     |..||...|.|.|  .||                        |:|.|..
  Fly   535 MEEGGAPSRRSGVEPAERPLMQ--QRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRF 597

Human   255 ------QLITDSPGSTSSVTS----------------------INSRVPDVPSES---------- 281
                  :..:.||.|:...||                      |:.|:..||..|
  Fly   598 SGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRV 662

Human   282 -------GSPVYV----------------------------------------------NQVKVR 293
                   |.|..|                                              ||.:..
  Fly   663 TISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAA 727

Human   294 VSDALLEKKKLMA---------------------------------------------ARERKAT 313
            ..:.:::|.|..|                                             |.|:|||
  Fly   728 GGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKAT 792

Human   314 KTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQ 378
            |.||::...|::||.||||::::...|.: |.....:.:...||||::|.|||||||:.|..|:.
  Fly   793 KVLGLVFFTFVLCWSPFFILNIIFAACPE-CQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRA 856

Human   379 AFHKLIRFKC 388
            ||.:|::..|
  Fly   857 AFIRLLKCNC 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	118/585 (20%)
		TM helix 1	51..77	CDD:320455	6/24 (25%)
		TM helix 2	84..110	CDD:320455	13/25 (52%)
		TM helix 3	122..152	CDD:320455	12/29 (41%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		0/1 (0%)
		TM helix 4	164..187	CDD:320455	7/36 (19%)
		TM helix 5	205..234	CDD:320455	8/105 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		9/43 (21%)
		TM helix 6	307..337	CDD:320455	15/29 (52%)
		TM helix 7	348..373	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		3/3 (100%)
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	57/187 (30%)
		TM helix 2	321..343	CDD:410628	13/21 (62%)
		TM helix 3	359..381	CDD:410628	8/21 (38%)
		TM helix 4	404..420	CDD:410628	6/15 (40%)
		TM helix 5	443..466	CDD:410628	6/22 (27%)
		7tm_GPCRs	<779..858	CDD:475119	31/79 (39%)
		TM helix 6	792..814	CDD:410628	11/21 (52%)
		TM helix 7	826..851	CDD:410628	12/24 (50%)