Protein Alignment HTR1B and Dop2R

DIOPT Version :10

• Sequence 1: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 139/532 - (26%)
• Similarity: 205/532 - (38%)
• Gaps: 202/532 - (37%)

Human    48 WKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVT 112
            |.::|:    |..:.|...|..||.:|.|.|.|.|..||.|.|||:.||||:::|||.:..:.|.
  Fly   378 WALILI----LFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVN 438

Human   113 GRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFS 177
            |.|.|..|||||:::.|:.|.|:||.:|..|::|||.|:|..::|:..:..:|..:.|.|||..|
  Fly   439 GAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAIS 503

Human   178 ISISLPPFFWRQAKAEEEVSECV-VNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILK 241
            .:|..|...........|...|. .|.|.||   ||::.:||.|.::::.||..|:...|||..|
  Fly   504 AAIGSPIVLGLNNTPNREPDVCAFYNADFIL---YSSLSSFYIPCIIMVFLYWNIFKALRSRARK 565

Human   242 QTPNR-------TG----------KRL-------------------------------------- 251
            |...|       ||          :||
  Fly   566 QRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISP 630

Human   252 ----------------------------------TRAQLIT-------DS--------------- 260
                                              |:.||:.       ||
  Fly   631 DIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVA 695

Human   261 PGSTSSVTSINSR----VPDVPSESGSPVY----------------------------------- 286
            |.|.|:.||...|    .||.|..||:.:.
  Fly   696 PASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAM 760

Human   287 --VNQVKVRVSDALL---------------------------------------EKKKLMAARER 310
              ::.|:..|.:|:.                                       :::|..|.:||
  Fly   761 KPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKER 825

Human   311 KATKTLGIILGAFIVCWLPFFIISLVMPIC---KDACWFHLAIFDFFTWLGYLNSLINPIIYTMS 372
            ||||||.|:||.|:.||||||..:::..:|   |..|...|..:...|||||:||.:||:|||:.
  Fly   826 KATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIF 890

Human   373 NEDFKQAFHKLI 384
            |.:|::||.|::
  Fly   891 NPEFRKAFKKIM 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	136/526 (26%)
		TM helix 1	51..77	CDD:320455	7/25 (28%)
		TM helix 2	84..110	CDD:320455	13/25 (52%)
		TM helix 3	122..152	CDD:320455	14/29 (48%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	8/22 (36%)
		TM helix 5	205..234	CDD:320455	10/28 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		11/40 (28%)
		TM helix 6	307..337	CDD:320455	18/29 (62%)
		TM helix 7	348..373	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		2/3 (67%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	72/193 (37%)
		TM helix 1	377..403	CDD:320181	8/28 (29%)
		TM helix 2	410..436	CDD:320181	13/25 (52%)
		TM helix 3	448..478	CDD:320181	14/29 (48%)
		TM helix 4	490..513	CDD:320181	8/22 (36%)
		TM helix 5	529..558	CDD:320181	12/31 (39%)
		7tm_GPCRs	<822..898	CDD:475119	36/75 (48%)
		TM helix 6	828..850	CDD:320181	14/21 (67%)
		TM helix 7	866..891	CDD:320181	13/24 (54%)