DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment okr and RDH54

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_009629.6	Gene:	RDH54 / 852365	SGDID:	S000000277	Length:	958	Species:	Saccharomyces cerevisiae

Alignment Length:	820	Identity:	264/820 - (32%)
Similarity:	405/820 - (49%)	Gaps:	176/820 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RRSLAPSQRGPLRPESRHSFTPPLLKKNKRSCQQELEREQELDR-RRLGALRDASNTSELPLPIR 65
            :.:|:.:...|..|.:..:.|.|..|.:....|..|.:...|:. :|..::...:|.....:| :
Yeast   188 KEALSQNMGNPSPPTTSTTETVPSTKNDGGKYQMPLSQLFSLNTVKRFKSVTKQTNEHMTTVP-K 251

  Fly    66 FTANSEYELAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVLFHPPAYT 130
            .:.||:         |:|:                         .|:.|....:..::.:..|..
Yeast   252 TSQNSK---------AKKY-------------------------YPVFDVNKIDNPIVMNKNAAA 282

  Fly   131 EHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEG---------------------K 174
            |            |.|:|||||...|||||||||:|||:|:.|                     .
Yeast   283 E------------VDVIVDPLLGKFLRPHQREGVKFMYDCLMGLARPTIENPDIDCTTKSLVLEN 335

  Fly   175 RGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGP-----ECKPT-------INKAIVVSPSSLVKN 227
            ..:.:||::||:|||||||..:||:|||:||.|     .|..:       ..|.:||.|.:|:.|
Yeast   336 DSDISGCLLADDMGLGKTLMSITLIWTLIRQTPFASKVSCSQSGIPLTGLCKKILVVCPVTLIGN 400

  Fly   228 WEKEFTKWLH-GRLLCLPMEGGTKENTIR-ALEQFSMTSARLGTPVLLISYETFRIYAEIL--CK 288
            |::||.|||: .|:..|.:......:..: |:..|  ...:....||:|.||.....:|.|  .|
Yeast   401 WKREFGKWLNLSRIGVLTLSSRNSPDMDKMAVRNF--LKVQRTYQVLIIGYEKLLSVSEELEKNK 463

  Fly   289 YEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAV 353
            :.:.|::|||||||||..:.....|..|..:|::||:||||||||.|::::::|:||.:||:.|.
Yeast   464 HLIDMLVCDEGHRLKNGASKILNTLKSLDIRRKLLLTGTPIQNDLNEFFTIIDFINPGILGSFAS 528

  Fly   354 FKRNFESAILRGQNTDS--TEQERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAK 416
            |||.|...|.|.::|.:  .|:..::..|:::|:|.:..:.|:||||.||.||||.|.::::..|
Yeast   529 FKRRFIIPITRARDTANRYNEELLEKGEERSKEMIEITKRFILRRTNAILEKYLPPKTDIILFCK 593

  Fly   417 LTAIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPDLI----YEKLTAREKGF 477
            ..:.|:..:.:.|:..::     |..:....::|..||.|||:|:.|.|:    |.|...::...
Yeast   594 PYSQQILAFKDILQGARL-----DFGQLTFSSSLGLITLLKKVCNSPGLVGSDPYYKSHIKDTQS 653

  Fly   478 ENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYG 542
            ::|.:        :.||   |||..:|..:|..||....:|||::||||||||:.|.|.......
Yeast   654 QDSYS--------RSLN---SGKLKVLMTLLEGIRKGTKEKVVVVSNYTQTLDIIENLMNMAGMS 707

  Fly   543 FVRLDGTMSIKKRSKVVDRFN-DPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQA 606
            ..||||::..|:|..:|..|| :|.  .|.|:||:|:||.||||:||:||.:||.||||:.|.||
Yeast   708 HCRLDGSIPAKQRDSIVTSFNRNPA--IFGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVDLQA 770

  Fly   607 MARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKH------FTRDDLK 665
            |:|:.||||||||:|||||.:|.|:|||||||..|.|||...:.::|...|.      |.::|||
Yeast   771 MSRIHRDGQKKPCFIYRLVTTGCIDEKILQRQLMKNSLSQKFLGDSEMRNKESSNDDLFNKEDLK 835

  Fly   666 DLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTDCTSHLSQWYHCSNNRGLPDNILAQAWMDC 730
            |||:...:..|:|||.:                                               |
Yeast   836 DLFSVHTDTKSNTHDLI-----------------------------------------------C 853

  Fly   731 KCVSFVFHHRSQAQEIVPSAEEEATDQPEEKPESRKRSST 770
            .|...       .:||    |...|:|.:...|.||||:|
Yeast   854 SCDGL-------GEEI----EYPETNQQQNTVELRKRSTT 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	120/345 (35%)
		DEXDc	179..328	CDD:238005	60/164 (37%)
		HELICc	493..622	CDD:238034	66/129 (51%)
RDH54	NP_009629.6	DUF2439	108..>158	CDD:402138
		DEXHc_RAD54	296..573	CDD:350762	100/278 (36%)
		SF2_C_SNF	663..789	CDD:350180	67/127 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0390
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S723
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760