Protein Alignment okr and RAD5

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_013132.1
• Gene: RAD5 / 850719
• SGDID: S000004022
• Length: 1169
• Species: Saccharomyces cerevisiae
• Alignment Length: 698
• Identity: 163/698 - (23%)
• Similarity: 266/698 - (38%)
• Gaps: 242/698 - (34%)

  Fly   180 GCIMADEMGLGKTLQCVTLV-----------------------------WTLLRQGPECKPTINK 215
            |.|::||||||||:...:||                             |.     ...||..:|
Yeast   527 GGILSDEMGLGKTVAAYSLVLSCPHDSDVVDKKLFDIENTAVSDNLPSTWQ-----DNKKPYASK 586

  Fly   216 -AIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTSARLGTPVLLISYETF 279
             .::|.|.||:..|..||||..:...:...:..|...::::.|    :|..:....|:|   .|:
Yeast   587 TTLIVVPMSLLTQWSNEFTKANNSPDMYHEVYYGGNVSSLKTL----LTKTKTPPTVVL---TTY 644

  Fly   280 RIYAEILCKYEVG-------------------MVICDEGHRLKNSDNLTYQALMGLKTKRRVLLS 325
            .|......|:..|                   .:|.||||.::|...:|.:|:|.|:.|.:.:|:
Yeast   645 GIVQNEWTKHSKGRMTDEDVNISSGLFSVNFYRIIIDEGHNIRNRTTVTSKAVMALQGKCKWVLT 709

  Fly   326 GTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVD 390
            ||||.|.|.:.||||.|:..:.......:| .|.|.....:|       .::|.:...   .:::
Yeast   710 GTPIINRLDDLYSLVKFLELDPWRQINYWK-TFVSTPFESKN-------YKQAFDVVN---AILE 763

  Fly   391 QCIIRRTNQILTK------YLPVKFEMVICAKLTAIQLELYTNFL--KSD-QVRRSLA--DCNEK 444
            ..::|||.|:..|      .||.| |:||.....:...:|...||  |:: .|:..:|  |..:|
Yeast   764 PVLLRRTKQMKDKDGKPLVELPPK-EVVIKRLPFSKSQDLLYKFLLDKAEVSVKSGIARGDLLKK 827

  Fly   445 ASLTALADITTLKKICSHPDLI------------YEKLTARE------------KGFENS----- 480
            .| |.|..|..|:::|.||.||            ..||...:            :.|:||
Yeast   828 YS-TILVHILRLRQVCCHPGLIGSQDENDEDLSKNNKLVTEQTVELDSLMRVVSERFDNSFSKEE 891

  Fly   481 -----QNV---LPSN------------YKPKDLNPELSGK----------FMLLDF--------- 506
                 |.:   .|.|            .:|.||:..|..:          |..::|
Yeast   892 LDAMIQRLKVKYPDNKSFQSLECSICTTEPMDLDKALFTECGHSFCEKCLFEYIEFQNSKNLGLK 956

  Fly   507 ------------MLAAIRAEGNDK----------------------------------VVLISNY 525
                        :||.::...|.|                                  ||:.|.:
Yeast   957 CPNCRNQIDACRLLALVQTNSNSKNLEFKPYSPASKSSKITALLKELQLLQDSSAGEQVVIFSQF 1021

  Fly   526 TQTLDLFEQ---------LARKRKYGFVRLDGTMSIKKRSKVVDRFNDPE-SDSFLFMLSSKAGG 580
            :..||:.|:         :|:..|:     ||.:|:|:|:.|:..|...: |...:.:||.||||
Yeast  1022 STYLDILEKELTHTFSKDVAKIYKF-----DGRLSLKERTSVLADFAVKDYSRQKILLLSLKAGG 1081

  Fly   581 CGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLS 645
            .||||..|:..:|.||.|:|:.::||:.|:.|.||.....:.|.:...|||||:|:.|..|:::.
Yeast  1082 VGLNLTCASHAYMMDPWWSPSMEDQAIDRLHRIGQTNSVKVMRFIIQDSIEEKMLRIQEKKRTIG 1146

  Fly   646 STIIDNNESAEKHFTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQM 693
            ..:                            ||.:..:.||.::.|||
Yeast  1147 EAM----------------------------DTDEDERRKRRIEEIQM 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137
		HepA	<156..650	CDD:440319	156/653 (24%)
		DEXHc_RAD54A	156..396	CDD:350825	62/264 (23%)
RAD5	NP_013132.1	HIRAN	176..284	CDD:400928
		HepA	<527..1143	CDD:440319	155/645 (24%)
		RING-HC_RAD5	909..973	CDD:438493	8/63 (13%)