Protein Alignment okr and HLTF

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_011511393.1
• Gene: HLTF / 6596
• HGNCID: 11099
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 956
• Identity: 188/956 - (19%)
• Similarity: 315/956 - (32%)
• Gaps: 373/956 - (39%)

  Fly     9 QRGPLRPESRHSFTPPLLKKNKRSCQQELEREQELDRRRLGALR----------------DASNT 57
            ||.|..|..:::     :|.|..:..|....::||    .|||.                .|:|.
Human    86 QRDPNNPYDKNA-----IKVNNVNGNQVGHLKKEL----AGALAYIMDNKLAQIEGVVPFGANNA 141

  Fly    58 SELPLPIRFTANSEYELAIAKVLARK-FKV---PMD---NYVPDYGGKRVLGVRRCISRRPLHDP 115
            ..:||.:.|....|...|::..|.:. ||:   |..   |....:|..|.         .|.:..
Human   142 FTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRA---------GPSYSM 197

  Fly   116 MACNALVLFHPPAYTEHERM-----------GMDPTKVLVHVVVDPLLSNILRPHQREGVRFM-- 167
            ....|:.:......||.:::           .|:|.:    .:..|||     |||::.:.:|
Human   198 PVHAAVQMTTEQLKTEFDKLFEDLKEDDKTHEMEPAE----AIETPLL-----PHQKQALAWMVS 253

  Fly   168 ------------------YECV-----EGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQG--- 206
                              |..:     :.:..|.:|.|:||:|||||||..:.::.|....|
Human   254 RENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPL 318

  Fly   207 ----------------------------------------------------------------- 206
                                                                             
Human   319 PIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSS 383

  Fly   207 -PECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPME--GGTKENTIRALEQFSMTSARLG 268
             |:.:.|..:.|..|.|..::.  .|..:.:.|:|..:..|  |..|..:.:.:|..:...|...
Human   384 RPKRRKTAVQYIESSDSEEIET--SELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTS 446

  Fly   269 T-----------------------------------PVLLIS--------------YETFRIY-- 282
            :                                   |:.::|              :..|.:|
Human   447 SVPTTKKKMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFYVYYG 511

  Fly   283 ------AEILCKYEVGM-------------------------VICDEGHRLKNSDNLTYQALMGL 316
                  ..:|.|.::.:                         ||.||||.::|.:....:|::.|
Human   512 PDRIREPALLSKQDIVLTTYNILTHDYGTKGDSPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDL 576

  Fly   317 KTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEK 381
            :::||.:|:||||||.|.:.:||::|:..:.......:.|..:..:..|.         :..:.:
Human   577 ESERRWVLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWHRTIQRPVTMGD---------EGGLRR 632

  Fly   382 TQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLEL------YTNFLKSDQVRRSLAD 440
            .|.||   ....:|||.....|..||              |||      ..:...||:.|:....
Human   633 LQSLI---KNITLRRTKTSKIKGKPV--------------LELPERKVFIQHITLSDEERKIYQS 680

  Fly   441 C------------NEKASLTALADI----TTLKKICSH----------------------PDLIY 467
            .            ||...|...||:    ..|::||.|                      |:.:.
Human   681 VKNEGRATIGRYFNEGTVLAHYADVLGLLLRLRQICCHTYLLTNAVSSNGPSAFSLGNDTPEELR 745

  Fly   468 EKLTAREKGFENS----------------------------------QNVLP------------- 485
            :||..:.|...:|                                  ||..|
Human   746 KKLIRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPCICQVIQNEQPHAKCPLCRNDIHE 810

  Fly   486 -------------SNYKPKDLNPELSGKFMLLDFMLAAIRAEG-NDKVVLISNYTQTLDLFEQLA 536
                         .:.|..|:....|.|...|...|..:|.:. |.|.:::|.:|..|.|.|...
Human   811 DNLLECPPEELARDSEKKSDMEWTSSSKINALMHALTDLRKKNPNIKSLVVSQFTTFLSLIEIPL 875

  Fly   537 RKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDS-FLFMLSSKAGGCGLNLIGANRLFMFDPDWNP 600
            :...:.|.||||:|:.|||.:.:..|.:.|:.| .:.:||.||||.||||..|:|:|:.||.|||
Human   876 KASGFVFTRLDGSMAQKKRVESIQCFQNTEAGSPTIMLLSLKAGGVGLNLSAASRVFLMDPAWNP 940

  Fly   601 ANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSS 646
            |.::|...|..|.|||:...|.:.:...|:||.:|:.|..|:.|::
Human   941 AAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNKKRELAA 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	9/56 (16%)
		HepA	<156..650	CDD:440319	153/775 (20%)
		DEXHc_RAD54A	156..396	CDD:350825	65/417 (16%)
HLTF	XP_011511393.1	HIRAN	60..153	CDD:400928	17/75 (23%)
		DEXHc_HLTF1_SMARC3	240..644	CDD:350829	67/422 (16%)
		DEAD-like_helicase_N	283..>357	CDD:475120	14/73 (19%)
		HepA	<472..990	CDD:440319	121/541 (22%)
		RING-HC_HLTF	759..813	CDD:438172	3/53 (6%)