DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment okr and Rad54b

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001034645.1	Gene:	Rad54b / 623474	MGIID:	3605986	Length:	886	Species:	Mus musculus

Alignment Length:	693	Identity:	273/693 - (39%)
Similarity:	388/693 - (55%)	Gaps:	76/693 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RRCISR-------------------RPLHDPMACNALVLFHPPAYTEHERMGMDPTKVLVHVVVD 149
            |:|.|.                   ||.|:|...||||:..|.  ..|:||.......:|.||:|
Mouse   205 RKCFSNPFKSVCQSTQAQGKRWNDCRPRHNPCTPNALVMPRPD--ENHQRMFNRHCSPIVDVVID 267

  Fly   150 PLLSNILRPHQREGVRFMYECVEGKRG-NFNGCIMADEMGLGKTLQCVTLVWTLLRQGP-ECKPT 212
            |.|.:.|||||::|:.|:||||.|.|. ...|.|:||||||||||||::|:|||..||| ..||.
Mouse   268 PHLVHHLRPHQKDGIIFLYECVMGMRAVGKCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKPV 332

  Fly   213 INKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTSARLGT---PVLLI 274
            |.|.::|:|.|||.||.|||.|||           |::...|..::|.......:.:   .||:|
Mouse   333 IKKTLIVTPGSLVNNWRKEFQKWL-----------GSERIKIFTVDQDHKVEEFINSTFHSVLII 386

  Fly   275 SYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSL 339
            |||......:.:.....|::|||||||||||...|..||..|..::.|:|:|||:||||.|:::|
Mouse   387 SYEMLLRSLDQIKTIPFGLLICDEGHRLKNSSIKTTTALSSLSCEKTVILTGTPVQNDLQEFFAL 451

  Fly   340 VNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKY 404
            |:||||.:||:.:.:::.:|..|:..:...|:::||:....:..||..|..:.|:|||.:::.||
Mouse   452 VDFVNPGILGSLSSYRKIYEEPIIISREPSSSKEERELGERRATELTRLTGRFILRRTQEVINKY 516

  Fly   405 LPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPDLIYEK 469
            ||.|.|.|:..:..|:|:|||...|:|..||..|....|.::  .|..|..|||:|:||.|::..
Mouse   517 LPPKIENVVFCRPGALQIELYRKLLRSQSVRFCLQGLLENSA--HLICIGALKKLCNHPCLLFSS 579

  Fly   470 LTAREKGFENSQN-----------VLPSNYKPKDLNPELSGKFMLLDFMLAAI-RAEGNDKVVLI 522
            :..:|......:|           |.|:.|.|...:.|.|||..:|..:||.| .....:||:|:
Mouse   580 VKGKEFSSSCEENEERNLCQGLLSVFPAGYNPLQFSEEESGKLQVLVKLLAVIHELRPTEKVILV 644

  Fly   523 SNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIG 587
            |||.|||::.|::.::..|...||||...:.:|..:||.||...|..|:|:|||||||.||||||
Mouse   645 SNYRQTLNVLEEVCKRHGYACARLDGQTPVSQRQHIVDSFNSKYSTDFIFLLSSKAGGVGLNLIG 709

  Fly   588 ANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNN 652
            .:.|.::|.|||||.|.|||:||||||||.|.:||||:.:|:|||||.|||..|:.||..::|..
Mouse   710 GSHLILYDIDWNPATDIQAMSRVWRDGQKHPVHIYRLLTTGTIEEKIYQRQISKQGLSGAVVDLT 774

  Fly   653 ESAEK-HFTRDDLKDLFTFDANILSDTHDKLKCKRC--------------VQNIQMKPPPEDTDC 702
            .|:|. .|:.::||:|||...:....|||.|.|: |              |.:.|.:..|:.:|.
Mouse   775 RSSEHIQFSVEELKNLFTLHESSHCVTHDLLDCE-CTGEKGHTEDASEGPVASRQCQFGPQKSDA 838

  Fly   703 -----TSHLSQWYHCSNNR-GLPDNILAQAWMDCKCVSFVFHH 739
                 .|.|.||.|.|.:. .|||..|.:...:   |||.|.:
Mouse   839 LRPLSMSQLKQWKHFSGDHLNLPDPFLERIREN---VSFFFQN 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	129/311 (41%)
		DEXDc	179..328	CDD:238005	66/152 (43%)
		HELICc	493..622	CDD:238034	64/129 (50%)
Rad54b	NP_001034645.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95
		SNF2_N	277..576	CDD:278600	129/311 (41%)
		DEXDc	299..440	CDD:238005	66/151 (44%)
		DEGH box	409..412		2/2 (100%)
		HDA2-3	531..807	CDD:288366	119/277 (43%)
		Helicase_C	619..736	CDD:278689	58/116 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0390
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810