Protein Alignment okr and CHD8

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001164100.1
• Gene: CHD8 / 57680
• HGNCID: 20153
• Length: 2581
• Species: Homo sapiens
• Alignment Length: 838
• Identity: 217/838 - (25%)
• Similarity: 363/838 - (43%)
• Gaps: 188/838 - (22%)

  Fly    26 LKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSEYELAIAKVLARKFKVPMDN 90
            |:|:|| ..|:|:|    .:.::..:|...:..|.|.      |.:| :.:.::|.....:..||
Human   688 LEKDKR-IHQKLKR----FKTKMAQMRHFFHEDEEPF------NPDY-VEVDRILDESHSIDKDN 740

  Fly    91 YVP----------------------DYGGKRVLGVRRCISRRP----LHDPMAC--NALVLFHPP 127
            ..|                      |....::...:|..||.|    ::.|.|.  ..|.|.|
Human   741 GEPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQASAWKKLELSH-- 803

  Fly   128 AYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFM----YECVEGKRGNFNGCIMADEMG 188
               |::.                  .|.||.:|.|||.::    |        |...||:|||||
Human   804 ---EYKN------------------RNQLREYQLEGVNWLLFNWY--------NRQNCILADEMG 839

  Fly   189 LGKTLQCVTL---VWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTK 250
            ||||:|.:..   |:.:...||        .:|::|.|.:.|||:||..|             |:
Human   840 LGKTIQSIAFLQEVYNVGIHGP--------FLVIAPLSTITNWEREFNTW-------------TE 883

  Fly   251 ENTI---------RALEQFSM----TSARL--GT---PVLLISYETFRIYAEILCKYEVGMVICD 297
            .|||         :.::|:.|    :..||  |.   ..|:.::|........|.:.|...||.|
Human   884 MNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIID 948

  Fly   298 EGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAI 362
            |.|||||.:.....:|..:..:.:|||:|||:||.:.|.:||::|:.|....:.:.|.::|...
Human   949 EAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDL- 1012

  Fly   363 LRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTN 427
                   .||       |:.|:|..::...::||..:.:.|.|..|.|.:|..:||.||.:.|..
Human  1013 -------KTE-------EQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRA 1063

  Fly   428 FLKSDQVRRSLADCNEKASLTALADITT----LKKICSHPDLI---YEKLTAREKGFENSQNVLP 485
            .|:     ::.:..::.|..|.:.::..    |:|.|:||.||   .||:...   |..:.:::|
Human  1064 ILE-----KNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYLINGAEEKILTE---FREACHIIP 1120

  Fly   486 SNYKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTM 550
            .::..:.: ...:||.:|:|.:|..::| |..||::.|...:.||:.|....:|:|.:.|:||.:
Human  1121 HDFHLQAM-VRSAGKLVLIDKLLPKLKA-GGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRV 1183

  Fly   551 SIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQ 615
            ....|...:|||:.|:||.|:|:|.::|||.|:||..|:...:||.||||.||.||.||..|.||
Human  1184 RGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQ 1248

  Fly   616 KKPCYIYRLVASGSIEEKILQRQTHKKSLSSTII------DNNESAEKHFTRDDLKDLFTFDANI 674
            .|...:|||:...|.|.::..:.:.|..|...::      |.|.:..:.|::.:::||....|..
Human  1249 SKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAYA 1313

  Fly   675 LSDTHDKLKCKRCVQNIQMKPPPEDTDCT--------SHLSQWYHCSNNR---GLPDNILAQAW- 727
            .....|....|.|.::|........|..|        :.....:..|.||   .|.|....|.|
Human  1314 AIMEEDDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFAKASFVASENRTDISLDDPNFWQKWA 1378

  Fly   728 -----------------MDCKCVSFVFHHRS--QAQEIVPSAEEEATDQPEEKPESRK 766
                             :|...|.....|.|  :..::|..::.|:.|  :|:|.||:
Human  1379 KKADLDMDLLNSKNNLVIDTPRVRKQTRHFSTLKDDDLVEFSDLESED--DERPRSRR 1434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	13/77 (17%)
		HepA	<156..650	CDD:440319	159/531 (30%)
		DEXHc_RAD54A	156..396	CDD:350825	75/264 (28%)
CHD8	NP_001164100.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..114
		PHA03247	<68..280	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..283
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..392
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..582
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..615
		CD1_tandem_CHD5-9_like	638..703	CDD:349315	7/19 (37%)
		CD2_tandem_CHD5-9_like	721..779	CDD:349310	7/58 (12%)
		PLN03142	810..>1409	CDD:215601	181/652 (28%)
		DEXHc_CHD8	811..1032	CDD:350818	75/264 (28%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	948..951		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1692..1712
		Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124	1789..2302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1991..2116
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2189..2229
		BRK	2310..2354	CDD:197800
		BRK	2379..2419	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2481..2581