DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment okr and dom

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster

Alignment Length:	973	Identity:	184/973 - (18%)
Similarity:	292/973 - (30%)	Gaps:	494/973 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 VVDP---LLSNILRPHQREGVRFMYECVEGKRGNFNGCIMADEMGLGKTLQCVTLV--------- 199
            ||.|   ||.:.||.:|..|:.::....|.|   .|| |:|||||||||:|.:.|:
  Fly   937 VVTPVPFLLKHSLREYQHIGLDWLVTMNERK---LNG-ILADEMGLGKTIQTIALLAHLACAKGN 997

  Fly   200 WTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTS 264
            |     ||.        ::|.|||::.|||.||.||..| ...|...|..||   |.|::...|.
  Fly   998 W-----GPH--------LIVVPSSVMLNWEMEFKKWCPG-FKILTYYGSQKE---RKLKRVGWTK 1045

  Fly   265 ARLGTPVLLISY-------ETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRV 322
            .. ...|.:.||       ::||   ....||    :|.||...:||..:..:|.|:...|:||:
  Fly  1046 PN-AFHVCITSYKLVVQDQQSFR---RKKWKY----LILDEAQNIKNFKSQRWQLLLNFSTERRL 1102

  Fly   323 LLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFE---SAILRGQNTDSTEQERQRAIEKTQE 384
            ||:|||:||||.|.:||::|:.|.:..:...||..|.   :.::.|.            :|..:.
  Fly  1103 LLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGN------------MEYNET 1155

  Fly   385 LIGLVDQCI----IRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKA 445
            ||..:.:.|    :||..:.:.|.:|.|:|.||..:|:..|..||.:|:...:.|.:|...|
  Fly  1156 LITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGN--- 1217

  Fly   446 SLTALADITTLKKICSHPDLI---------------------------YE--------------- 468
            .|:.:..:..|:|:|:||::.                           |:
  Fly  1218 LLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLL 1282

  Fly   469 ---------------------------------------------------------KLTAREKG 476
                                                                     ||.|.:.|
  Fly  1283 HLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVG 1347

  Fly   477 ------FENS-----QNVLPSN------------------------------------------- 487
                  .|.|     :|:|||.
  Fly  1348 ASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALS 1412

  Fly   488 ----------------------------------------------------------------- 487

  Fly  1413 VLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRT 1477

  Fly   488 --------------------------------------------------YKPKD---------- 492
                                                              ||.::
  Fly  1478 TVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRL 1542

  Fly   493 ----------------------------------------------------------------- 492

  Fly  1543 AALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNH 1607

  Fly   493 --------------------------------------------------------LNPELS--- 498
                                                                    |.|:|:
  Fly  1608 LLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLH 1672

  Fly   499 --------------------GKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGF 543
                                ||...:|.:|..::..|: :|::.:..|:.||:.|.......:.:
  Fly  1673 PIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGH-RVLIFTQMTKMLDVLEAFLNYHGHIY 1736

  Fly   544 VRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMA 608
            :||||:..:::|..:::|||. :...|.|:||:::||.|:||.||:.:..:|.||||..|.||..
  Fly  1737 LRLDGSTRVEQRQILMERFNG-DKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQD 1800

  Fly   609 RVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKHFTRDDLKDLFTFD 671
            |..|.||.:..:|||||:..:||..||::...|:.||...|:.......:|....:|||||.:
  Fly  1801 RCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTME 1863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	101/329 (31%)
		DEXDc	179..328	CDD:238005	56/164 (34%)
		HELICc	493..622	CDD:238034	44/151 (29%)
dom	NP_001286676.1	HSA	543..614	CDD:214727
		ASF1_hist_chap	<674..831	CDD:304562
		FAM176	<824..>868	CDD:291517
		SNF2_N	952..1238	CDD:278600	101/329 (31%)
		DEXDc	969..1108	CDD:238005	56/164 (34%)
		Helicase_C	1692..1806	CDD:278689	39/115 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467178
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840