DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment okr and Chd3

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster

Alignment Length:	660	Identity:	183/660 - (27%)
Similarity:	310/660 - (46%)	Gaps:	109/660 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 LRPHQREGVRFM-YECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTINKAIVV 219
            |.|.|.|||.:: |...:|     ...|:|||||||||:|.|..:::|.::| .|:   ...::.
  Fly   267 LHPFQIEGVSWLRYSWGQG-----IPTILADEMGLGKTIQTVVFLYSLFKEG-HCR---GPFLIS 322

  Fly   220 SPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTSARLGT----------PVLLI 274
            .|.|.:.|||:|...|. ..|.|:...||.....:....:.|.......|          .|:|.
  Fly   323 VPLSTLTNWERELELWA-PELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLT 386

  Fly   275 SYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSL 339
            |||...:.|..|...:...::.||.|||:::.:..::.|...:...::||:|||:||:|.|.:.|
  Fly   387 SYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHL 451

  Fly   340 VNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKY 404
            :||::.........|:..|         ||.:::|:.:.:.:      :::..::||....:.|.
  Fly   452 LNFLSSGKFNDLQTFQAEF---------TDVSKEEQVKRLHE------ILEPHMLRRLKADVLKS 501

  Fly   405 LPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKAS--LTALADI-TTLKKICSHPDLI 466
            :|.|.|.::..:|:::|.:.|.:.|     .::....|:|..  :.:|.:| ..|:|.|:||
  Fly   502 MPPKSEFIVRVELSSMQKKFYKHIL-----TKNFKALNQKGGGRVCSLLNIMMDLRKCCNHP--- 558

  Fly   467 YEKLTAREKGFENSQNVLPSN-YKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLD 530
            |...:|.|:.     .:.||. |:...|. :.|||..||..||..::|: |.:|:|.|..|:.|:
  Fly   559 YLFPSAAEEA-----TISPSGLYEMSSLT-KASGKLDLLSKMLKQLKAD-NHRVLLFSQMTKMLN 616

  Fly   531 LFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFD 595
            :.|.......|.:.|:||::....|.|.:||||||.|:.|:|:||::|||.|:||..|:.:.:||
  Fly   617 VLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFD 681

  Fly   596 PDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTII-DNNESAEKHF 659
            .||||.||.||.:|..|.||||...|||.|...|:||:|:|...||..|:..:: ........:|
  Fly   682 SDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNF 746

  Fly   660 TRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTDCTSHLSQWYHCSN---------- 714
            ::|:|:|:..|      .|.|..|..:                    |:..|..:
  Fly   747 SKDELEDILRF------GTEDLFKDGK--------------------SEAIHYDDKAVADLLDRT 785

  Fly   715 NRGLPDNILAQAWMDCKCVSFVF-------------HHRSQAQEIVPSAEEEATDQPEEK-PESR 765
            |||:.:.   ::|.:....||..             .:.:.|:...|...|....:.:.| |:.:
  Fly   786 NRGIEEK---ESWANEYLSSFKVASYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQ 847

  Fly   766 KRSSTPASDD 775
            |:.|..:..|
  Fly   848 KKQSQQSQVD 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	83/320 (26%)
		DEXDc	179..328	CDD:238005	44/158 (28%)
		HELICc	493..622	CDD:238034	56/128 (44%)
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991
		CHROMO	181..233	CDD:214605
		SNF2_N	270..561	CDD:278600	84/323 (26%)
		DEXDc	288..440	CDD:238005	44/156 (28%)
		Helicase_C	585..700	CDD:278689	51/115 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467214
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840