DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment okr and Iswi

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster

Alignment Length:	689	Identity:	190/689 - (27%)
Similarity:	295/689 - (42%)	Gaps:	168/689 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SQRGPLRPESRHSFTPPLLK-KNK-------RSCQQELEREQELDRRRLGALRDASNTSELPLPI 64
            |.:.|.:|:.|    |..:| |:|       |..:.|.|.::||       |.:.|.|.|:   .
  Fly    64 SAKSPTKPKGR----PKKIKDKDKEKDVADHRHRKTEQEEDEEL-------LAEDSATKEI---F 114

  Fly    65 RFTANSEYELAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVLFHPPAY 129
            ||.|:                                                         |||
  Fly   115 RFDAS---------------------------------------------------------PAY 122

  Fly   130 TEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKRGNFNGCIMADEMGLGKTLQ 194
                                 :.|..:|.:|..|:.:|....|   ...|| |:|||||||||||
  Fly   123 ---------------------IKSGEMRDYQIRGLNWMISLYE---NGING-ILADEMGLGKTLQ 162

  Fly   195 CVTLVWTLL----RQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHG-RLLCLPMEGGTKENTI 254
            .::|:..|.    :.||.        ||:.|.|.::||..||.||... |.:||..:..|:...|
  Fly   163 TISLLGYLKHFKNQAGPH--------IVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFI 219

  Fly   255 RALEQFSMTSARLGTP----VLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMG 315
            |.:..          |    |.:.|||.......:..|:....::.||.||:||..:...:.|..
  Fly   220 RDVLM----------PGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILRE 274

  Fly   316 LKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIE 380
            .||..|:|::|||:||:|.|.::|:||:.|::..::..|...|.:....|.:...|   |..|:.
  Fly   275 FKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDALIT---RLHAVL 336

  Fly   381 KTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKA 445
            |         ..::||....:.|.|..|.||.|...|:.:|.:.||..|..|....:.|...||.
  Fly   337 K---------PFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKM 392

  Fly   446 SLTALADITTLKKICSHPDLIYEKLTAREKGFENSQNVLPSNYKPKDLNPEL---SGKFMLLDFM 507
            .|..:  :..|:|..:||.|           |:.::   |.  .|...:..|   |||..:||.:
  Fly   393 RLQNI--LMQLRKCTNHPYL-----------FDGAE---PG--PPYTTDTHLVYNSGKMAILDKL 439

  Fly   508 LAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLF 572
            |..::.:|: :|::.|..|:.||:.|.....|.|.:.||||....:.|::.:..||...|..|||
  Fly   440 LPKLQEQGS-RVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLF 503

  Fly   573 MLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQR 637
            |||::|||.|:||..|:.:.::|.||||..|.|||.|..|.||||...::||:...::||||::|
  Fly   504 MLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVER 568

  Fly   638 QTHKKSLSSTIIDNN---ESAEKHFTRDDLKDLFTFDAN 673
            ...|..|...:|...   ::......:|::.::..|.||
  Fly   569 AEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGAN 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	95/315 (30%)
		DEXDc	179..328	CDD:238005	52/157 (33%)
		HELICc	493..622	CDD:238034	52/131 (40%)
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	1/2 (50%)
		SNF2_N	131..411	CDD:278600	96/326 (29%)
		DEXDc	148..287	CDD:238005	52/157 (33%)
		HELICc	422..553	CDD:238034	52/131 (40%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467166
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840