DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment okr and Etl1

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	170/561 - (30%)
Similarity:	279/561 - (49%)	Gaps:	95/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 NGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTINKA--IVVSPSSLVKNWEKEFTKWLHGRLL 241
            || |:|||||||||:|.:..:..|...|      :::|  ::|.|||.:.|||.|.::|...  |
  Fly   309 NG-ILADEMGLGKTIQVIAFLAYLKENG------LSQAAHLIVVPSSTLDNWEAEISRWCPE--L 364

  Fly   242 CLPMEGGTKENTIRALEQFSMTSARLGTPVLLISY----------ETFRIYAEILCKYEVGMVIC 296
            .:....|:::...|...:|: .....|..|||.:|          :.||:     ||.:  .||.
  Fly   365 VVEKYHGSQDERRRMRGRFA-KDGFTGFDVLLTTYHIVGSTPEERKMFRV-----CKLD--YVIF 421

  Fly   297 DEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTA-----AVFKR 356
            ||.|.|||.....|..|:.:..:.|:||:|||:||:|.|..||:.||.|:....:     ::|.:
  Fly   422 DEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAK 486

  Fly   357 NFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQ 421
            ..:|    ..:.|...|.::..|::.:.   ::...::||..:.:.|.||.|..:|....:::.|
  Fly   487 KGKS----DGDQDEVSQFQETQIQRAKR---IMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQ 544

  Fly   422 -------LELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPDLIYEKLT-AREKGFE 478
                   ::.|:|      .:..:...:|:|.:..:.:   :::|.:||.|:....| |..:||.
  Fly   545 KIYYHELVDYYSN------NKGEVCSSSERAGIAIMME---MRRIANHPLLMRHYFTDANLRGFS 600

  Fly   479 ------------NSQNV-----LPSNYK---------------PKDLNPELSGKFMLLDFMLAAI 511
                        |.|.:     :.|:::               |.:|..: ||||:.||.:|..:
  Fly   601 KRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICD-SGKFLYLDTLLPKL 664

  Fly   512 RAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSS 576
            :|||: :|:|.|.:|..||:.|:..|.||:||.||||..::..|..::..||..:| .|:|:||:
  Fly   665 KAEGH-RVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IFVFLLST 727

  Fly   577 KAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHK 641
            ||||.|:||..|:...:.|.|:||.||:||..|..|.||::|..||||::..:|||.||.....|
  Fly   728 KAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEK 792

  Fly   642 KSLSSTIIDNNESAEKHFTRDDLKDLFTFDANILSDTHDKL 682
            ..|... |.:||..|.|..|..:| |.|....:..|..::|
  Fly   793 LKLEKD-ITSNEKGEVHEQRCVVK-LLTTALGLDKDQEEQL 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	83/310 (27%)
		DEXDc	179..328	CDD:238005	52/160 (33%)
		HELICc	493..622	CDD:238034	56/128 (44%)
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	83/310 (27%)
		DEXDc	308..453	CDD:238005	52/160 (33%)
		Helicase_C	651..765	CDD:278689	52/115 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467153
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840