Protein Alignment okr and HELLS

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001275996.1
• Gene: HELLS / 3070
• HGNCID: 4861
• Length: 884
• Species: Homo sapiens
• Alignment Length: 765
• Identity: 197/765 - (25%)
• Similarity: 320/765 - (41%)
• Gaps: 206/765 - (26%)

  Fly    26 LKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSEYELAIAKVLARKFKVPMDN 90
            :||.|.|.  :...|:.:.|::.|...::.|.||:       .:.|..|::||      |...:|
Human   109 VKKGKNSI--DASEEKPVMRKKRGREDESYNISEV-------MSKEEILSVAK------KNKKEN 158

  Fly    91 YVPDYGGKRVLGVRRCIS------------RRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVL 143
            ...:.....:     |:.            :..|.:.:..|....|.|......:.:.....|
Human   159 EDENSSSTNL-----CVEDLQKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQPVPFQQPK-- 216

  Fly   144 VHVVVDPLLSNILRPHQREG---VRFMYECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQ 205
             |     ....::|.:|.||   :|.::|      ...|| |:|||||||||:||:..:..::::
Human   217 -H-----FTGGVMRWYQVEGMEWLRMLWE------NGING-ILADEMGLGKTVQCIATIALMIQR 268

  Fly   206 GPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLP--MEGGTKENTIRALEQFSMTSARLG 268
            |     .....:|..|.|.:.||..||.::...    :|  :..||:|...:.:...   ..|.|
Human   269 G-----VPGPFLVCGPLSTLPNWMAEFKRFTPD----IPTMLYHGTQEERQKLVRNI---YKRKG 321

  Fly   269 TPVLLISYETFRIYAEILCKYEVGM-------------VICDEGHRLKNSDNLTYQALMGLKTKR 320
                     |.:|:..::..:|:.|             :|.|||||:||......:.|.......
Human   322 ---------TLQIHPVVITSFEIAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADN 377

  Fly   321 RVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAI------ 379
            ::||:|||:||:|:|.:||:||:.|::......|:..|:...|.....|...:||::.:
Human   378 KLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQ 442

  Fly   380 ---------EKTQE------LIGLVDQCIIR----------RTN-QILTKYL------------P 406
                     |.|.|      |....|...||          .|| :|||.:|            |
Human   443 ERIPRMYVSEFTDEGFFEGKLPSRKDLYDIRPYENTYLLKLHTNFEILTPFLLRRLKSDVALEVP 507

  Fly   407 VKFEMVICAKLTAIQLELYT-----------------------------------NFLKSD---- 432
            .|.|:|:.|.|:..|...||                                   |:.|.|
Human   508 PKREVVVYAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPN 572

  Fly   433 -------QVR------RSLADCN----EKASLTALADITTLKKICSHPDLIYEKLTAREKGFENS 480
                   |::      |::.:.|    .:.:|.....:..|:|.|:||.||...:....:.|:..
Human   573 ELEKLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQEFKID 637

  Fly   481 QNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVR 545
            :.::.:           ||||::||.||..::..|: ||:|.|..|..||:.......|.:.|.|
Human   638 EELVTN-----------SGKFLILDRMLPELKKRGH-KVLLFSQMTSMLDILMDYCHLRDFNFSR 690

  Fly   546 LDGTMSIKKRSKVVDRFN-DPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMAR 609
            |||:||..:|.|.:..|| |||  .|:|::|::|||.|:||..|:.:.::|.||||.:|.||..|
Human   691 LDGSMSYSEREKNMHSFNTDPE--VFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDR 753

  Fly   610 VWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKHF 659
            ..|.||.||..:||||.:.:|::||::|...|:.|...||..|     ||
Human   754 CHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKN-----HF 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	8/61 (13%)
		HepA	<156..650	CDD:440319	170/612 (28%)
		DEXHc_RAD54A	156..396	CDD:350825	74/288 (26%)
HELLS	NP_001275996.1	DEXHc_HELLS_SMARCA6	220..499	CDD:350767	80/306 (26%)
		PLN03142	221..>869	CDD:215601	174/625 (28%)