Protein Alignment okr and Ercc6

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001423629.1
• Gene: Ercc6 / 306274
• RGDID: 1311509
• Length: 1474
• Species: Rattus norvegicus
• Alignment Length: 760
• Identity: 219/760 - (28%)
• Similarity: 357/760 - (46%)
• Gaps: 139/760 - (18%)

  Fly     9 QRG--PLRPESRHSFTPPLLKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSE 71
            |||  ||.||.|.........:...|...:.|.|:|.:...:..|.....:.||. |:|  ...:
  Rat   349 QRGKRPLEPEERPGAEGDTEGEESGSSPTDGEEEEEQEEEGVAVLSSDDISYELK-PLR--KGQK 410

  Fly    72 YELAIAKVLARKFKVPM----DNYVPDY-----------GGKRVLGVRRCISRRPLHDP------ 115
            ||.          |||:    |::.|..           ||::|       ||||  |.
  Rat   411 YEK----------KVPVQEIDDDFFPSSEEEDEAVEGRGGGRKV-------SRRP--DDGDEDYY 456

  Fly   116 ----MACNALVLFHPPAYTEHERMGMDPTKVLVHVVVDP------LLSNILRPHQREGVRFMYE- 169
                ...|.|.|      .:.|::.::..........|.      .|...|..:|:.|||:::|
  Rat   457 KQRLRRWNRLRL------QDKEKLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWEL 515

  Fly   170 -CVEGKRGNFNGCIMADEMGLGKTLQCVT----LVWTLLR-QGPECK-----PTINKAIVVSPSS 223
             |.:.      |.|:.||||||||:|.:.    |.::.:| :|...:     ||    ::|.|::
  Rat   516 HCQQA------GGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPT----LIVCPTT 570

  Fly   224 LVKNWEKEFTKWLHGRLLCLPMEGGT----KENTIRALEQFSMTSARLGTPVLLISYETFRIYAE 284
            ::..|.|||..|.....:.:..|.|:    ||..:|.:....        .||:.||...|:..:
  Rat   571 VMHQWVKEFHTWWPPFRVAILHETGSCAHRKERLVRDIVHCH--------GVLITSYSYIRLMQD 627

  Fly   285 ILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLG 349
            .:.:::...||.||||:::|.:.....|....:|..|::|||:|:||:|.|.:||.:|..|..||
  Rat   628 DISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFTFPGKLG 692

  Fly   350 TAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRR--TNQILTKYLPVKFEMV 412
            |..||...|...|..|..::::..:.:.|.:....|...::..::||  ::..::..||.|.|.|
  Rat   693 TLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQV 757

  Fly   413 ICAKLTAIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPDLIYEKLTAREKGF 477
            :..:||..|.::|.||:.|..|.|.|...|:     ..:.:..|:|||:||||.        .|.
  Rat   758 LFCRLTDEQHKVYQNFIDSKAVYRILNGENQ-----IFSGLVALRKICNHPDLF--------SGG 809

  Fly   478 ENSQNVLPSNYKPKDLNPE------LSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLA 536
            ..:.:.||.:    .|..|      .|||.::::.:|.....:| .:|:|.|...|.|.:.|...
  Rat   810 PKNTSALPED----GLEEEQFGYWKRSGKMIVVESLLKIWHKQG-QRVLLFSQSRQMLHILEVFL 869

  Fly   537 RKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPA 601
            |..||.::::|||.:|..|..::.::|: ::..|:|:|:::.||.|:||.||||:.::||||||:
  Rat   870 RAHKYSYLKMDGTTTIASRQPLITKYNE-DTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPS 933

  Fly   602 NDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKHFTRDDLKD 666
            .|.||..|.||.||||...:|||:.:|:|||||..||..|:.|::.:: .:....:.|..:||.:
  Rat   934 TDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVL-KDPKQRRFFKSNDLYE 997

  Fly   667 LFTF---DANILSDTH----------DKLKC---KRCVQNIQMKP 695
            |||.   ||:..::|.          ..|||   ||....:||.|
  Rat   998 LFTLTSPDASQGTETSAIFAGTGSNIQTLKCHFKKRTPPVLQMDP 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	16/74 (22%)
		HepA	<156..650	CDD:440319	164/517 (32%)
		DEXHc_RAD54A	156..396	CDD:350825	72/255 (28%)
Ercc6	NP_001423629.1	cc_ERCC-6_N	83..159	CDD:411064
		HepA	316..981	CDD:440319	202/696 (29%)
		CSB_WHD	1402..1473	CDD:439329