DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment okr and Rad54l

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001128432.1	Gene:	Rad54l / 298429	RGDID:	1310600	Length:	748	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	418/756 - (55%)
Similarity:	546/756 - (72%)	Gaps:	24/756 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRRSLAPSQRGPLRPESRHS----FTPPLLKKNKRSCQQELEREQ---ELDRRRLGALRDASNTS 58
            |||||||||....:||...|    :.|..:...||....|.:.:|   ...|:.|..|.:.....
  Rat     1 MRRSLAPSQLARRKPEDISSDDEDWQPETVTPKKRKSTAETQAQQCFLSPFRKPLTQLLNRPPCL 65

  Fly    59 ELPLPIRFTANSEYELAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVL 123
            :         :|::|..|..:|::.||||:.||.... |.|.||::|...||.||||:...||||
  Rat    66 D---------SSQHEAFIRSILSKPFKVPIPNYQGPL-GSRALGLKRAGVRRALHDPLEEGALVL 120

  Fly   124 FHPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKR--GNFNGCIMADE 186
            :.||..:.|:::.:|..|:.|||||||:||.:|||||||||:|::|||..:|  |: :|||||||
  Rat   121 YEPPPLSVHDQLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGS-HGCIMADE 184

  Fly   187 MGLGKTLQCVTLVWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKE 251
            |||||||||:||:||||||.|||||.|.||:|||||||||||..|..|||.||:..|.::||:|:
  Rat   185 MGLGKTLQCITLMWTLLRQSPECKPEIEKAVVVSPSSLVKNWYNEVEKWLGGRIQPLAIDGGSKD 249

  Fly   252 NTIRALEQF-SMTSARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMG 315
            ...|.||.| :...||:.:|:|:|||||||::.|:|.|..||:||||||||||||:|.|||||..
  Rat   250 EIDRKLEGFMNQRGARVPSPILIISYETFRLHVEVLKKGNVGLVICDEGHRLKNSENQTYQALDS 314

  Fly   316 LKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIE 380
            |.|.||||:|||||||||.||:|||:|||..:||||..||::||..||:.::..::|.:||...|
  Rat   315 LNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKSRDAAASEADRQLGEE 379

  Fly   381 KTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKA 445
            :.:|||.:|::|:||||:.||:||||||.|.|:|.:||.:|.|||..||:..:....|.:  .|.
  Rat   380 RLRELISIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPEEELHE--GKM 442

  Fly   446 SLTALADITTLKKICSHPDLIYEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAA 510
            |:::|:.||:|||:|:||.|||:|..|.|.|||.:..:.|..|..|.:.|:||||.::||::||.
  Rat   443 SVSSLSSITSLKKLCNHPALIYDKCVAEEDGFEGTLGIFPPGYNSKAVEPQLSGKMLVLDYILAM 507

  Fly   511 IRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLS 575
            .|:..:|||||:|||||||||||:|.|.|:|.:||||||||||||:|||:|||.|.|..|:||||
  Rat   508 TRSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLS 572

  Fly   576 SKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTH 640
            ||||||||||||||||.|||||||||||||||||||||||||.||||||:::|:|||||.|||:|
  Rat   573 SKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKICYIYRLLSAGTIEEKIFQRQSH 637

  Fly   641 KKSLSSTIIDNNESAEKHFTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTDCTSH 705
            ||:|||.::|..:..|:||:..:||:|||.|...||||||:|.|:|||.|.|:.|||:.:||||.
  Rat   638 KKALSSCVVDEEQDVERHFSLGELKELFTLDEASLSDTHDRLHCRRCVNNRQVWPPPDGSDCTSD 702

  Fly   706 LSQWYHCSNNRGLPDNILAQAW-MDCKCVSFVFHHRSQAQE 745
            |:||.|.::.|||.|.:|..|| .....::||||.||..::
  Rat   703 LAQWNHNTDKRGLQDEVLQAAWDASSTAITFVFHQRSHEEQ 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	180/309 (58%)
		DEXDc	179..328	CDD:238005	99/149 (66%)
		HELICc	493..622	CDD:238034	98/128 (77%)
Rad54l	NP_001128432.1	Rad54_N	<74..>123	CDD:285821	23/49 (47%)
		SNF2_N	156..463	CDD:278600	180/309 (58%)
		DEXDc	177..327	CDD:238005	99/149 (66%)
		HELICc	490..619	CDD:238034	98/128 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340106
Domainoid	1	1.000	341	1.000	Domainoid score	I1054
eggNOG	1	0.900	-	-		E2759_KOG0390
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48227
Inparanoid	1	1.050	820	1.000	Inparanoid score	I441
OMA	1	1.010	-	-		QHG58624
OrthoDB	1	1.010	-	-		D93727at2759
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	1	1.000	-	-		oto96578
orthoMCL	1	0.900	-	-		OOG6_102456
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.670