DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment okr and RAD54B

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_036547.1	Gene:	RAD54B / 25788	HGNCID:	17228	Length:	910	Species:	Homo sapiens

Alignment Length:	700	Identity:	278/700 - (39%)
Similarity:	400/700 - (57%)	Gaps:	60/700 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LARK-FKVPMDNYV-PDYGGKRVLGVRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKV 142
            :||| |..|..:.. |.....|....:.|   :|.|||...|:||:..|.  ..|:.:.......
Human   223 VARKCFSNPFKSVCKPSSKENRQNDFQNC---KPRHDPYTPNSLVMPRPD--KNHQWVFNKNCFP 282

  Fly   143 LVHVVVDPLLSNILRPHQREGVRFMYECVEGKRGNFN-GCIMADEMGLGKTLQCVTLVWTLLRQG 206
            ||.||:||.|...|||||:||:.|:||||.|.|.|.. |.|:||||||||||||::|:|||..||
Human   283 LVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAILADEMGLGKTLQCISLIWTLQCQG 347

  Fly   207 P-ECKPTINKAIVVSPSSLVKNWEKEFTKWLHG-RLLCLPMEGGTKENTIRALEQFSMTSARLGT 269
            | ..||.|.|.::|:|.|||.||:|||.|||.. |:....::...|      :|:|..:   :..
Human   348 PYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHK------VEEFIKS---IFY 403

  Fly   270 PVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLT 334
            .||:||||......:.:...:..::|||||||||||...|..||:.|..::|::|:||||||||.
Human   404 SVLIISYEMLLRSLDQIKNIKFDLLICDEGHRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQ 468

  Fly   335 EYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQ 399
            |:::|::||||.:||:.:.:::.:|..|:..:...::|:|::....:..||..|....|:|||.:
Human   469 EFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAELTCLTGLFILRRTQE 533

  Fly   400 ILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPD 464
            |:.||||.|.|.|:..:..|:|:|||...|.|..||..|....|.:  ..|..|..|||:|:||.
Human   534 IINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENS--PHLICIGALKKLCNHPC 596

  Fly   465 LIYEKLTAREKGFENSQNVLPSNYK------PKDLNPEL-----SGKFMLLDFMLAAI-RAEGND 517
            |::..:..:|......:|...|.||      |.|.||.|     |||..:|..:||.| .....:
Human   597 LLFNSIKEKECSSTCDKNEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTE 661

  Fly   518 KVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCG 582
            ||||:|||||||::.:::.::..|.:.||||...|.:|.::||.||...|..|:|:|||||||.|
Human   662 KVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIVDGFNSQHSSFFIFLLSSKAGGVG 726

  Fly   583 LNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSST 647
            |||||.:.|.::|.|||||.|.|||:||||||||.|.:||||:.:|:|||||.|||..|:.|...
Human   727 LNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGA 791

  Fly   648 IIDNNESAEK-HFTRDDLKDLFTFDANILSDTHDKLKCKRCV----------------QNIQMKP 695
            ::|..:::|. .|:.::||:|||...:....|||.|.|: |.                ::.|:.|
Human   792 VVDLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCE-CTGEEVHTGDSLEKFIVSRDCQLGP 855

  Fly   696 PPEDTD-----CTSHLSQWYHCSNNR-GLPDNILAQAWMDCKCVSFVFHH 739
            ..:.::     ..|.|.||.|.|.:. .|.|..|.:.   .:.|||:|.:
Human   856 HHQKSNSLKPLSMSQLKQWKHFSGDHLNLTDPFLERI---TENVSFIFQN 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	131/309 (42%)
		DEXDc	179..328	CDD:238005	66/151 (44%)
		HELICc	493..622	CDD:238034	68/134 (51%)
RAD54B	NP_036547.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		HepA	<296..815	CDD:223627	232/529 (44%)
		DEGH box	431..434		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0390
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D93727at2759
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820