DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment okr and ERCC6

DIOPT Version :9

Sequence 1:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_000115.1	Gene:	ERCC6 / 2074	HGNCID:	3438	Length:	1493	Species:	Homo sapiens

Alignment Length:	885	Identity:	239/885 - (27%)
Similarity:	394/885 - (44%)	Gaps:	196/885 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSQRGP----LRPESRHSFTPPLLKKNKRSCQQEL----EREQELDRRRLGALRDASNTSELPLP 63
            |..|.|    :|||:         :.:....:.|.    |.|:|.|....||..|.|..
Human   349 PKARRPWESDMRPEA---------EGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGD------ 398

  Fly    64 IRFTANSEYEL-AIAKVLARKFKVPM----DNYVPDY-------------GGKRVLG-------- 102
                 .::||| .:.|...|:.|||:    |::.|..             ||.|.:|
Human   399 -----GTDYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDE 458

  Fly   103 ------VRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVLVHVVVDP------LLSNI 155
                  :||....| |.|                :.:|:.::..........|.      .|...
Human   459 DYYKQRLRRWNKLR-LQD----------------KEKRLKLEDDSEESDAEFDEGFKVPGFLFKK 506

  Fly   156 LRPHQREGVRFMYE--CVEGKRGNFNGCIMADEMGLGKTLQCVT----LVWTLLR-QGPECK--- 210
            |..:|:.|||:::|  |.:.      |.|:.||||||||:|.:.    |.::.:| :|...:
Human   507 LFKYQQTGVRWLWELHCQQA------GGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEG 565

  Fly   211 --PTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGT----KENTIRALEQFSMTSARLGT 269
              ||    ::|.|::::..|.|||..|.....:.:..|.|:    ||..||.:....
Human   566 LGPT----VIVCPTTVMHQWVKEFHTWWPPFRVAILHETGSYTHKKEKLIRDVAHCH-------- 618

  Fly   270 PVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLT 334
            .:|:.||...|:..:.:.:|:...||.||||:::|.:.....|....:|..|::|||:|:||:|.
Human   619 GILITSYSYIRLMQDDISRYDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLR 683

  Fly   335 EYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRR--T 397
            |.:||.:|:.|..|||..||...|...|..|..::::..:.:.|.:....|...::..::||  :
Human   684 ELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKS 748

  Fly   398 NQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSH 462
            :..::..||.|.|.|:..:||..|.::|.||:.|.:|.|.|     ...:...:.:..|:|||:|
Human   749 DVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYRIL-----NGEMQIFSGLIALRKICNH 808

  Fly   463 PDLIYEKLTAREKGFENSQNVLPSNYK--PKDLNPEL----------SGKFMLLDFMLAAIRAEG 515
            |||           |...    |.|.|  |.|   ||          |||.::::.:|.....:|
Human   809 PDL-----------FSGG----PKNLKGLPDD---ELEEDQFGYWKRSGKMIVVESLLKIWHKQG 855

  Fly   516 NDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGG 580
             .:|:|.|...|.||:.|...|.:||.::::|||.:|..|..::.|:|: ::..|:|:|:::.||
Human   856 -QRVLLFSQSRQMLDILEVFLRAQKYTYLKMDGTTTIASRQPLITRYNE-DTSIFVFLLTTRVGG 918

  Fly   581 CGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLS 645
            .|:||.||||:.::||||||:.|.||..|.||.||||...:|||:.:|:|||||..||..|:.|:
Human   919 LGVNLTGANRVVIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLT 983

  Fly   646 STIIDNNESAEKHFTRDDLKDLFTF---DAN-------ILSDTHDKLKCKRCVQNIQMKPP-PED 699
            :.:: .:....:.|..:||.:|||.   ||:       |.:.|...::..:|....:::|. ..|
Human   984 NRVL-KDPKQRRFFKSNDLYELFTLTSPDASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGAD 1047

  Fly   700 TDCTSHLSQWYHCSNNRGLPDNILAQAWMDCKC--VSFVFHHRSQAQEIVP------------SA 750
            .|......   ..::|..:.|...::...:.|.  |:.|..:||...:..|            ..
Human  1048 HDVPKRKK---FPASNISVNDATSSEEKSEAKGAEVNAVTSNRSDPLKDDPHMSSNVTSNDRLGE 1109

  Fly   751 EEEATDQPEE-----------KPESRKRSSTPASDDSADE 779
            |..|...|||           ......::|.|:.|:|.||
Human  1110 ETNAVSGPEELSVISGNGECSNSSGTGKTSMPSGDESIDE 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	96/324 (30%)
		DEXDc	179..328	CDD:238005	47/162 (29%)
		HELICc	493..622	CDD:238034	52/138 (38%)
ERCC6	NP_000115.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269\|PubMed:29203878	1..510		38/197 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..323
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..453		29/123 (24%)
		SNF2_N	510..812	CDD:278600	97/335 (29%)
		DEXDc	527..677	CDD:238005	47/161 (29%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	646..649		2/2 (100%)
		HELICc	830..960	CDD:238034	50/131 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1147		19/107 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1318..1384
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000269\|PubMed:20541997	1400..1428
		Winged-helix domain (WHD). /evidence=ECO:0000305\|PubMed:29203878	1429..1493
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269\|PubMed:26620705	1446..1493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910