Protein Alignment okr and CHD3

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_005256484.1
• Gene: CHD3 / 1107
• HGNCID: 1918
• Length: 2115
• Species: Homo sapiens
• Alignment Length: 759
• Identity: 203/759 - (26%)
• Similarity: 328/759 - (43%)
• Gaps: 162/759 - (21%)

  Fly   127 PAYTEHER---------MGMDPTKVLVH---------------VVVDPLLSNILRP--------- 158
            |.|.||::         ||.||.:...:               ...||.:....:|
Human   730 PEYEEHKQSYWRHRELIMGEDPAQPRKYKKKKKELQGDGPPSSPTNDPTVKYETQPRFITATGGT 794

  Fly   159 ---HQREGVRFM-YECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTINKAIVV 219
               :|.||:.:: :...:|     ...|:|||||||||:|.:..:::|.::|    .|....:|.
Human   795 LHMYQLEGLNWLRFSWAQG-----TDTILADEMGLGKTIQTIVFLYSLYKEG----HTKGPFLVS 850

  Fly   220 SPSSLVKNWEKEFTKWL------------HGRLLCLPMEGGTKENTIR-ALEQFSM-TSARLGTP 270
            :|.|.:.|||:||..|.            ..|.:....|...::|.|: ..:.|.| ..|::...
Human   851 APLSTIINWEREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFH 915

  Fly   271 VLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTE 335
            |||.|||...|....|.......::.||.|||||:.:..::.|.|.|...::||:|||:||:|.|
Human   916 VLLTSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEE 980

  Fly   336 YYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQI 400
            .:.|:||:.||.......|...|         .|.:::::   |:|..:|:|   ..::||....
Human   981 LFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ---IKKLHDLLG---PHMLRRLKAD 1030

  Fly   401 LTKYLPVKFEMVICAKLTAIQLELYTNFL-KSDQVRRSLADCNEKASLTALADITTLKKICSHPD 464
            :.|.:|.|.|:::..:|:.:|.:.|...| ::.:...|....|:.:.|..:.|   |||.|:||.
Human  1031 VFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRGGGNQVSLLNIMMD---LKKCCNHPY 1092

  Fly   465 LIYEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTL 529
            |.  .:.|.|      ...|||.........:.|||.|||..||..::.:|: :|::.|..|:.|
Human  1093 LF--PVAAME------SPKLPSGAYEGGALIKSSGKLMLLQKMLRKLKEQGH-RVLIFSQMTKML 1148

  Fly   530 DLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMF 594
            ||.|.......|.:.|:||.::...|.:.:||||.|.:..|.|:||::|||.|:||..|:.:.:|
Human  1149 DLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIF 1213

  Fly   595 DPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTII-DNNESAEKH 658
            |.||||.||.||.:|..|.||.....|||.|...|:||:|.|....|..|:..:: ....|....
Human  1214 DSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKAGS 1278

  Fly   659 FTRDDLKDLFTF-----------------DANILSDTHDKLKCKRCVQNIQMKPPPEDTD---CT 703
            .::.:|.|:..|                 |::::.  :|.....|.:...|  ...||||   ..
Human  1279 MSKQELDDILKFGTEELFKDENEGENKEEDSSVIH--YDNEAIARLLDRNQ--DATEDTDVQNMN 1339

  Fly   704 SHLSQW----YHCSNNRGL----------PDNILAQAWMDCKCVSFVFHHRSQAQEIV------- 747
            .:||.:    |.......:          .:|:....|     ...:.||..|.||.:
Human  1340 EYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYW-----EKLLRHHYEQQQEDLARNLGKG 1399

  Fly   748 ----------PSAEEEATDQPE-------------EKPESRKRS 768
                      .:|:|:..:|.|             |:||.|::|
Human  1400 KRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEGRRQS 1443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137
		HepA	<156..650	CDD:440319	162/522 (31%)
		DEXHc_RAD54A	156..396	CDD:350825	74/266 (28%)
CHD3	XP_005256484.1	CHDNT	207..260	CDD:462357
		PHD1_CHD_II	440..482	CDD:277006
		PHD2_CHD_II	517..559	CDD:277007
		CD1_tandem_CHD3-4_like	564..642	CDD:349314
		CD2_tandem_CHD3-4_like	687..741	CDD:349309	4/10 (40%)
		PLN03142	778..>1332	CDD:215601	170/593 (29%)
		DEXHc_CHD3	795..1026	CDD:350813	73/254 (29%)
		DUF1087	<1373..1416	CDD:461922	8/47 (17%)
		CHDII_SANT-like	1437..1576	CDD:461920	4/7 (57%)
		PHA03418	1578..>1727	CDD:177646
		CHDCT2	1797..1923	CDD:462358