DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and CHD6

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_016883588.1	Gene:	CHD6 / 84181	HGNCID:	19057	Length:	2716	Species:	Homo sapiens

Alignment Length:	1619	Identity:	474/1619 - (29%)
Similarity:	723/1619 - (44%)	Gaps:	356/1619 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 NGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNETE---AGQQ 163
            ||..|     |..|.:|.......:.|.||...:..:.:..   |||::..|.....|   |.:.
Human    81 NGMED-----SGGGGTGVKKKRKKKEPGDQEGAAKGSKDRE---PKPKRKREPKEPKEPRKAKEP 137

  Fly   164 QPASDASADESSDSSANV-SPTSSSSSSEEEE-----EDYRPKRTRQARKP--PTAAEKSKKAPA 220
            :.|.:....:..|.:... .|..:|.:.|.:|     :.....::|:|.|.  ||..||.|
Human   138 KKAKEHKEPKQKDGAKKARKPREASGTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKK---- 198

  Fly   221 PKNKKKTWDSDESDESEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFS-SEDSD----DD 280
             |.|:|   |:.:.||.:.|..::....|.|..:|..:...:::..|:||... :||.|    ||
Human   199 -KGKRK---SETTVESLELDQGLTNPSLRSPEESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDD 259

  Fly   281 DASKRCATRRKGAAVSYKEASEDEATDSEDLLEFEYDESQAATTAATAEE--EEKCETIERILAQ 343
            |          |..::...|....|.             .|:|.|..|||  |:....||:|||.
Human   260 D----------GETIAVLGAGRTSAL-------------SASTLAWQAEEPPEDDANIIEKILAS 301

  Fly   344 RAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDM 408
            :           |:..:       |.|     .|..:.|. |.:|::.:||:|..|   ||:.::
Human   302 K-----------TVQEV-------HPG-----EPPFDLEL-FYVKYRNFSYLHCKW---ATMEEL 339

  Fly   409 K-----AKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKP 468
            :     |:.:|:..|      :||..:......|.|.|.          ..|..||||:......
Human   340 EKDPRIAQKIKRFRN------KQAQMKHIFTEPDEDLFN----------PDYVEVDRILEVAHTK 388

  Fly   469 DDGTEE----YLCKWQSLPYAESTWE-----DAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIK 524
            |..|.|    ||.||.||||.|||||     |.|.|        ::|   ||.:..|.     ||
Human   389 DAETGEEVTHYLVKWCSLPYEESTWELEEDVDPAKV--------KEF---ESLQVLPE-----IK 437

  Fly   525 Y--RP---KFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFL 584
            :  ||   .:.:::...|:.:|. .||:||::|:||||.:|....:.|||||||||||||:|.||
Human   438 HVERPASDSWQKLEKSREYKNSN-QLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFL 501

  Fly   585 YSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKR-- 647
            ..:| :..::||||.:.||||:|.|:|||..|. :||.:.|.|...||::|||||..:..::.
Human   502 SEIF-LRGIHGPFLIIAPLSTITNWEREFRTWT-EMNAIVYHGSQISRQMIQQYEMVYRDAQGNP 564

  Fly   648 ----LKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGT 708
                .||:.::||:|::|.|...|..:.|:.:::||||||||.:..|.:.||.....|::|:|||
Human   565 LSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGT 629

  Fly   709 PLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDVEKSLPA 772
            |||||::||::||:|:.|.:|.:...|..:.|:.: ::...:|...|:|.:|||:|.||||:|..
Human   630 PLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAP 694

  Fly   773 KVEQILRVEMTSLQKQYYKWILTKNFDALRKG-KRGSTSTFLNIVIELKKCCNHAALIRPSEFEL 836
            |.|.|:.||:|::||:||:.||.|||..|.|| .:.:....:|.::||:|||||..||..:|.::
Human   695 KQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKI 759

  Fly   837 MGLQQ----------DEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQK 891
              |:.          |..||.:::.:|||||:||||.:|...||:|||||||||.||:|.|||.:
Human   760 --LEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQ 822

  Fly   892 RHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQND 956
            |.:.::|:||.::|.:|:.|:|.|....|..|.|||.||||||||||..|||.||||||||||||
Human   823 RRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQND 887

  Fly   957 LQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHS 1021
            ||||||.|||||...|.:|||:|..|.|.::.::|..|:.||..|:|.::..|.|      ||
Human   888 LQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGGT------NG-- 944

  Fly  1022 SNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVC--DIDEILRRAETRNEDPEMPADDLLSAFK 1084
              ....:|.::..:|:.||.....|| |.:....|  |||:||:|   |.....:.::...|.|.
Human   945 --VQQLSKMEVEDLLRKGAYGALMDE-EDEGSKFCEEDIDQILQR---RTHTITIQSEGKGSTFA 1003

  Fly  1085 VASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAID-DQERAKEMEDLYL--PPRR 1146
            .||..|.......|:           ||...|     :.:.|..: |.|...|.|.|.:  |..|
Human  1004 KASFVASGNRTDISL-----------DDPNFW-----QKWAKIAELDTEAKNEKESLVIDRPRVR 1052

  Fly  1147 KTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAEL 1211
            |...:.|..:.                 |...|.....|..|.||.:..|  :.:|...:..||.
Human  1053 KQTKHYNSFEE-----------------DELMEFSELDSDSDERPTRSRR--LNDKARRYLRAEC 1098

  Fly  1212 RRF--------------IRSYKKFPAPLHR--MEAIACDAEL---------QEKPLAELKRLGEM 1251
            .|.              |.::.:|...|:.  ||.| |.|.|         .||..:.:..|...
Human  1099 FRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMI-CRALLVYCVKHYKGDEKIKSFIWELITP 1162

  Fly  1252 LHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQEL------- 1309
            ..|...|.|..|    |..:|    |..:.|:.:.|.:..|.....:|..|..|..|:
Human  1163 TKDGQAQTLQNH----SGLSA----PVPRGRKGKKTKNQLLIPELKDADWLATCNPEVVLHDDGY 1219

  Fly  1310 -----QPLN--------------EIMPSMPEERQQWSFNIKTRAPVFDVD--------WGIEEDT 1347
                 |..|              ||:....|:..:.|...:...|:.|:|        |..|.|.
Human  1220 KKHLKQHCNKVLLRVRMLYYLKAEILGEAAEKAFEGSPARELDVPLPDIDYMEIPVDWWDAEADK 1284

  Fly  1348 KLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQR 1412
            .||.|::::|...:..|:.||.|...:|:.:.|.:...|:|                .:|.|...
Human  1285 SLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSLSAEQ----------------GVTDGTSD 1333

  Fly  1413 RQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQH 1477
            ...|....:.::|                  ||.....:...|||:                 ..
Human  1334 IPERGNTDKEDNA------------------EDKVDGLQKQTESSS-----------------DG 1363

  Fly  1478 GDPAKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRALEVLGDLDPSIFNECKEKMRPVKKALK 1542
            ||.....||..:|:.:..:..:....|:........|.|       .:::..|..         |
Human  1364 GDGVFSEKKDDSRAAQDGSDPDKSPWPVSSALTARLRRL-------VTVYQRCNR---------K 1412

  Fly  1543 ALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAETEKKEW----RSNLWYFVSKF 1597
            .|.:|:: |...:|....::.:.:...::|: :|..|:   |.|    :::.:..||.|
Human  1413 ELCRPEI-LGPGNQGYWVQEEMFRRTSEMDL-INKEAQ---KRWTRREQADFYRTVSSF 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	13/52 (25%)
		Chromo	458..509	CDD:278797	24/59 (41%)
		SNF2_N	548..829	CDD:278600	127/288 (44%)
		DEXDc	564..709	CDD:238005	66/150 (44%)
		Helicase_C	852..967	CDD:278689	74/114 (65%)
		DUF4208	1521..1610	CDD:290618	14/81 (17%)
		DUF3824	1795..>1894	CDD:289625
CHD6	XP_016883588.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810