DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and CHD9

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_005256225.1	Gene:	CHD9 / 80205	HGNCID:	25701	Length:	2898	Species:	Homo sapiens

Alignment Length:	2259	Identity:	582/2259 - (25%)
Similarity:	896/2259 - (39%)	Gaps:	611/2259 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HLKPDKSKQFDPGCRALNESANSIGSDEQDDTREEANGTDHSGSGSGSGSSGSDSD--------- 61
            |:.|:          :|.:|:..:.|:..:.|.     :|.:||.|.|...|...:
Human   280 HISPN----------SLLQSSAVLASNHTNQTL-----SDFTGSNSFSPHRGIKQESTQHILNPN 329

  Fly    62 ------------SDSSSGNSSDGRSS------PEPEDKSLSVAGFPPTAAA-----------AQA 97
                        |....||.|:.:.|      |:|.|....:..|......           .|.
Human   330 TSLNSNNFQILHSSHPQGNYSNSKLSPVHMNFPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQV 394

  Fly    98 DSKTNGFT--DDQE----------DSSSDGSSGS----DSDSDAE-------GPSDQRNQSINNA 139
            :|:|..||  |.::          |.|:.|...|    |.|.|.:       .|||.....:.:.
Human   395 ESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSDMAQTQLQSQ 459

  Fly   140 NTSSSLPKPEQNEEEDNETEAGQQQPASDASAD---------------------------ESSDS 177
            ..|............|......|:||.|...:|                           ||...
Human   460 ARSWHSSFSNHQHLHDRNHLCLQRQPPSSKKSDGSGTYTKLQNTQVRVMSEKKQRKKVESESKQE 524

  Fly   178 SANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAA---EKSKKAPAPKNKKKTWDSDESDESEDS 239
            .||...:.:.:.::|..|...| |.......|||:   ::.||....|:|.|..||.::
Human   525 KANRIISEAIAKAKERGERNIP-RVMSPENFPTASVEGKEEKKGRRMKSKPKDKDSKKT------ 582

  Fly   240 DDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSD----------DDDASKRCATRRKGAA 294
                .|..|.|......:..:...::::|....|.|.||          |.|:.||.:.|:
Human   583 ----KTCSKLKEKTKIGKLIITLGKKQKRKNESSDEISDAEQMPQHTLKDQDSQKRRSNRQ---- 639

  Fly   295 VSYKEASED-EATDSEDLLEFEYDESQAATTAATAEE-----------EEKCETIERILAQRAGK 347
            :..|:.:|| |...||:  |.:........:|....|           ||....:::||:.|..|
Human   640 IKRKKYAEDIEGKQSEE--EVKGSMKIKKNSAPLPGEQPLQLFVENPSEEDAAIVDKILSSRTVK 702

  Fly   348 RGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKG 412
            :               ...|....|        || :|.:|:|.:||:|..|.:|..|  :|.|.
Human   703 K---------------EISPGVMID--------TE-EFFVKYKNYSYLHCEWATEEQL--LKDKR 741

  Fly   413 M-KKLDNFIKKEKEQAYWRRYAG----PEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGT 472
            : :|:..|..::.::|::  :|.    |.:.||.|               |||::......|..|
Human   742 IQQKIKRFKLRQAQRAHF--FADMEEEPFNPDYVE---------------VDRVLEVSFCEDKDT 789

  Fly   473 EE----YLCKWQSLPYAESTWE-----DAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPK 528
            .|    ||.||.||||.:||||     |.|.:        |:|...::|             ||.
Human   790 GEPVIYYLVKWCSLPYEDSTWELKEDVDLAKI--------EEFEQLQAS-------------RPD 833

  Fly   529 FSRIKNQPEFL----------SSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICF 583
            ..|:...|..:          .:|..||:||::||||||.:|....:.|||||||||||||:|.|
Human   834 TRRLDRPPSNIWKKIDQSRDYKNGNQLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITF 898

  Fly   584 LYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSK-- 646
            ||.:. :..:.||||.:.||||:..|:|||..|. |:|||.|.|.:.||::|||||..|..|:
Human   899 LYEIL-LTGIRGPFLIIAPLSTIANWEREFRTWT-DINVVVYHGSLISRQMIQQYEMYFRDSQGR 961

  Fly   647 ----RLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITG 707
                ..:|..|:||:|::|.....|..::|..:::||||||||.:..|.:.||..:..|::|:||
Human   962 IIRGAYRFQAIITTFEMILGGCGELNAIEWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTG 1026

  Fly   708 TPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDVEKSLP 771
            |||||:::||::||||:.|.:|.:...|..:.|:.: ::...:|...|:|.:|||:|:||||.|.
Human  1027 TPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKKLA 1091

  Fly   772 AKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTS--TFLNIVIELKKCCNHAALIRPSEF 834
            .|.|.|:.||:|::||:||:.||.|||..|.|| .|.|:  ..:|.::||:|||||..||:.:|.
Human  1092 PKEETIIEVELTNIQKKYYRAILEKNFSFLSKG-AGQTNVPNLVNTMMELRKCCNHPYLIKGAEE 1155

  Fly   835 ELMG--------LQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQK 891
            :::|        ...|..||.:::.:|||||:||||.::|..||:|||||||||.||:|.|||..
Human  1156 KILGEFRDTYNPAASDFHLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRCLDILEDYLIH 1220

  Fly   892 RHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQND 956
            :.:.::|:||.::|.:|:.|:|.|:...|..|.|||.||||||||||..|||.||||||||||||
Human  1221 KRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQND 1285

  Fly   957 LQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHS 1021
            ||||||.|||||...|.:|||||..|.|.::.:||..|:.||..|:|.|            :|..
Human  1286 LQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRASLKLGLDKAVLQSM------------SGRE 1338

  Fly  1022 SN---SNPFNKDDLSAILKFGAEELFKDEQEHDDDLVC--DIDEI-LRRAETRNEDPEMPADDLL 1080
            ||   ....:|.::..:|:.||..... |:|.:....|  |||:| |||.:|...:.|...
Human  1339 SNVGGIQQLSKKEIEDLLRRGAYGAIM-EEEDEGSKFCEEDIDQILLRRTKTITIESEGRG---- 1398

  Fly  1081 SAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYL--P 1143
            |.|..||..|.......|:           ||...|.    :..:||..|.|.......|.:  |
Human  1399 STFAKASFVASGNRTDISL-----------DDPNFWQ----KWAKKAEIDIEAISGRNSLVIDTP 1448

  Fly  1144 PRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTD 1208
            ..||.....:..|                  |...||....|..|.:|:.| ||.  ::..|:..
Human  1449 RIRKQTRPFSATK------------------DELAELSEAESEGDEKPKLR-RPC--DRSNGYGR 1492

  Fly  1209 AELRRF--------------IRSYKKFPAPL--HRMEAIACDAELQEKPLAELKRLGEMLHDRCV 1257
            .|..|.              |.|:.:|...|  |.:| |.|.|.|.                .|:
Human  1493 TECFRVEKNLLVYGWGRWREILSHGRFKRQLNEHDVE-IICRALLA----------------YCL 1540

  Fly  1258 QFLHEHKEEESKTAATD-ETP---------------GAKQRRARATFSVKLGGVSFNAKKL---- 1302
              :|...:|:.|....| .||               .|...|.|....||....||:.:|.
Human  1541 --VHYRGDEKIKGFIWDLITPTEDGQTRELQNHLGLSAPVPRGRKGKKVKTQTSSFDIQKAEWLR 1603

  Fly  1303 -LACEQELQP----------LNEIMPSMPEERQQWSFNIKTRA------PVFD-VD--------- 1340
             ...||.||.          .|:::     .|.:..:.:|...      .||| ||
Human  1604 KYNPEQLLQDEGYKKHIKHHCNKVL-----LRVRMLYYLKQEVIGNECQKVFDGVDASDIDVWVP 1663

  Fly  1341 -----------WGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAE 1394
                       |..:.|..||.|::::|...:..::.||.|...:::...|.:...|:|
Human  1664 EPDHSEVPAEWWDFDADKSLLIGVFKHGYEKYNTIRADPALCFLERVGKPDEKAVAAEQ------ 1722

  Fly  1395 YLLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGD---------- 1449
                  :.|..:....:..:.:|..:...|......|:...:.....||:...||
Human  1723 ------RANDYMDGDVEDPEYKPAPAIFKDDIEDDVSSPGDLVIADGDGQLMEGDKVYWPTQSAL 1781

  Fly  1450 -----------ARTVAESSNSQVDPSTASPHNA--PATEQHG-DPAKKAK--------------- 1485
                       .||.......|:.|:.:.|.:.  |..|:.. :|...||
Human  1782 TTRLRRLITAYQRTNKNRQIQQIQPTFSVPTSVMQPIYEEATLNPKMAAKIERQQRWTRREEADF 1846

  Fly  1486 ---------------------KSKARSKKTSASDNNGNKPMHFTANNEPRALEVLGD---LDPSI 1526
                                 |.:|.::....:|::..|.::...:...|...:...   :||:|
Human  1847 YRVVSTFGVVFDPDRGQFDWTKFRAMARLHKKTDDSLEKYLYAFMSMCRRVCRLPSKEELVDPNI 1911

  Fly  1527 F----NECK--------EKMRPVKKALKALDQPDVSLSDQDQL--------------QHTRDCLL 1565
            |    .|.:        |.:|.|::  :||..|  .|.::.:|              .|.||.|:
Human  1912 FIQPITEERASRTLYRIELLRKVRE--QALRHP--QLFERLKLCHPNPDLPVWWECGPHDRDLLI 1972

  Fly  1566 QIGK------QIDVCLNP----------YAETEKKEWRSNL----WYFV----SKFTE----LDA 1602
            ...|      ...:..:|          |::::....|::.    .|.|    |..|.    |||
Human  1973 GAAKHGVSRTDYHILRDPELSFMAAQRNYSQSKMAHSRTSTPLLQQYQVALSASPLTSLPRLLDA 2037

  Fly  1603 KRL----FKIYKHALKQKAGGDGEAKGKDKGSSGSP-----AKSKP----NGVTTEEKEKERDRS 1654
            |.:    .|:....||:      |.:..::.|..|.     .||:|    |||..:....:  :|
Human  2038 KGIILEEMKVKSENLKE------EPQSSEEESMSSVETRTLIKSEPVSPKNGVLPQATGDQ--KS 2094

  Fly  1655 GGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGLAGAPGGGIGDNLKSM 1719
            ||   |.:.|:........|.|..|.|.:   |.:.::..|:.:|:.|           |:.:|.
Human  2095 GG---KCETDRRMVAARTEPLTPNPASKK---PRVHKRGSESSSDSDS-----------DSERSS 2142

  Fly  1720 SFKRLNMDRHEDRKKHHRGPDYYGGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAP 1784
            ...|.:.........|.|.           ||.|....|.|.....:|.||..:....     :.
Human  2143 CSSRSSSSSSSSSCSHSRS-----------GSSSSSSSSCSSASSSSSSSTSSSSSSS-----SS 2191

  Fly  1785 SGYTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQGSYHRERDRRPEKRRYPSGLPPHPY---SS 1846
            |....:.:..:::.|.........||     .....|....:|...:..:..:|.|...|   ..
Human  2192 SSEESDSDEEEAQKRAESTTHMKAYD-----EESVASLSTTQDETQDSFQMNNGTPESAYILQGG 2251

  Fly  1847 HYLPPNYYGLPNGAVPGLPPPSSVYRSDPRG-YPVMPRDYPADYRRSDY 1894
            :.|..:|:......:..|   .|:.::..:| :|...|.|.|:...|.|
Human  2252 YMLAASYWPKDRVMINRL---DSICQTVLKGKWPSARRSYDANTVASFY 2297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	15/48 (31%)
		Chromo	458..509	CDD:278797	22/59 (37%)
		SNF2_N	548..829	CDD:278600	132/289 (46%)
		DEXDc	564..709	CDD:238005	68/150 (45%)
		Helicase_C	852..967	CDD:278689	73/114 (64%)
		DUF4208	1521..1610	CDD:290618	30/149 (20%)
		DUF3824	1795..>1894	CDD:289625	18/102 (18%)
CHD9	XP_005256225.1	COG5048	80..479	CDD:227381	39/213 (18%)
		ETAA1	<164..355	CDD:317720	16/89 (18%)
		CHROMO	692..752	CDD:237991	21/85 (25%)
		Chromo	773..827	CDD:306815	23/76 (30%)
		SNF2_N	811..>1480	CDD:331286	287/742 (39%)
		BRK	2483..2532	CDD:197800
		BRK	2557..2601	CDD:197800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810