DRSC/TRiP Functional Genomics Resources

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Protein Alignment Chd1 and Ercc6l2

DIOPT Version :10

Sequence 1:NP_001245851.1 Gene:Chd1 / 33505 FlyBaseID:FBgn0250786 Length:1900 Species:Drosophila melanogaster
Sequence 2:NP_001013626.2 Gene:Ercc6l2 / 76251 MGIID:1923501 Length:1537 Species:Mus musculus


Alignment Length:1443 Identity:330/1443 - (22%)
Similarity:537/1443 - (37%) Gaps:418/1443 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   545 LRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGP------------- 596
            |||||.:|..:|...:.:....||.|:||||||||.|.||.::.   |..|.             
Mouse   122 LRDYQREGAQFLYRHYIEGRGCILGDDMGLGKTIQVISFLAAVL---HKKGTREDIENNMPEFLL 183

  Fly   597 --------------FLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKR 647
                          ||.|.|||.:..|:.|.|.|. ...|....|..|..||::        .|:
Mouse   184 KSMKKKPPSTAKKMFLIVAPLSVLYNWKDELDTWG-YFRVTVLHGSKKDNELLR--------LKQ 239

  Fly   648 LKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQN 712
            .|....|||||.:....:.|.:|:|:|::||||||:||..:.:.:.:|......|:.:|||.|||
Mouse   240 RKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQN 304

  Fly   713 SLKELWALLHFIMPDKFDTWENFE------VQHGNAED----------KGYTRLHQQLEPYILRR 761
            ::||||.::.:.:|....:..:|:      |:||....          |...||.:::..:.|||
Mouse   305 NMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRR 369

  Fly   762 VKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDAL---------------------RKGK 805
            .|..::..||.|.::::...:|..||..|:.:|.....||                     :...
Mouse   370 TKTLIKGQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVALILTSSQPCTCGSGQKRRKCCYKTNS 434

  Fly   806 RGST--STFLNIVIELKKCCNHAALIRP-------------------SEF-ELMGLQQDEALQTL 848
            ||.|  :..|:.:..|:|..||.||::.                   |.| :.:...:|.|.:||
Mouse   435 RGDTVRTLCLSYLTVLQKVANHVALLQAASTSKHQETVIKRICDRVFSRFPDFVQKSKDAAFETL 499

  Fly   849 L--KGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQA 911
            .  |.|||:.:|.:||...::...:||:||...::||||..|.......::|||||.|.|.|.:.
Mouse   500 SDPKYSGKMKVLQQLLNHFRKQRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKI 564

  Fly   912 LDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYR 976
            :..||:....:.| |:||.|||||:|...|:.||:||..|||.|||||..||:||||...|.:.|
Mouse   565 VKEFNSSQDVNIC-LVSTMAGGLGLNFVGANVVILFDPTWNPANDLQAVDRAYRIGQCRDVKVLR 628

  Fly   977 LVTARSVEEQIVERAKQKMVLDHLVI-----------------QRMDTTG--------------- 1009
            |::..:|||.:..|...|..|..:|:                 .|.:..|               
Mouse   629 LISLGTVEEIMYLRQVYKQQLHCVVVGSENAKRYFEAVQGSKEHRGELFGVHNLFKLRSQGSCLT 693

  Fly  1010 RTVLDKSGN------------------------------------------------GHSSNSNP 1026
            |.:|::.|.                                                |||.....
Mouse   694 RDILEREGQVEAGIMTATTWLKGEPSAQELETPRDPDCQEPTDVCELYSDISDEESVGHSLGKTD 758

  Fly  1027 FNK-DDLS---------AILKFGAEELF----KDEQEHDDDLV-----CDIDEILRRAETRNEDP 1072
            .:| .|.|         .:|:.|..:||    |.:|:.|.:.|     .|...:...||.|....
Mouse   759 KHKFSDTSRTPGFPAQLTLLQCGFSKLFEAKYKSDQDGDGNPVPSDGSSDEQPMCLSAEARQAAR 823

  Fly  1073 EMPADDLLSAFKVASIAAFEEEPSDSVSKQD-------------QNAAGEEDD------------ 1112
            :...|         |:...|.:.||::...|             ||.:.|.||            
Mouse   824 QKTWD---------SVCTSEHQKSDNIQTPDEKCVSDKSEKTLEQNVSSESDDETKDHRTAGHHC 879

  Fly  1113 -------SKDWDDIIPEGF--RKAIDDQERAK----EMEDLYLPPRRKTAANQNEGKRGAGKGG- 1163
                   |:|.|.|.|..:  ::...:..|.|    |.||  .........|..:.::.:|:|. 
Mouse   880 MGQGDTESEDSDVIFPTQYPTQRIPKNHIRFKLLLGESED--SEAENPVKVNHGDDRQNSGRGNG 942

  Fly  1164 ----------------KGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELR 1212
                            :.::..||...:||        ..|..|:.|.|   |::.|  |..:.:
Mouse   943 PVPNLLCLENMTSKSVRKRKGTDDISDESD--------DIDMFPKSRIR---KQRAT--TSLKFK 994

  Fly  1213 RFIRSYKKFP-APLHRMEA---IACDAELQEKPLAELKRLGEML---HDRCVQFLHEHKEEESKT 1270
            |...:.:|.. :|:...||   .|.|.:...:.:.:.....:.|   |....:..|..:..:.|.
Mouse   995 RKKENKRKLDNSPVTAKEANQVCAADGDRSSQVIEDFSSSDDNLSLSHLSFTKLSHRAETVKDKI 1059

  Fly  1271 AATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPE-------------- 1321
            :.:.:.||..::  ..|| :.....||..:.:::.||....:::|:..:.|              
Mouse  1060 SLSPKLPGPDKK--NNTF-ISRKPPSFLNEGVISQEQICNSMDKILDGVQEVAYIHSNQNVIGSS 1121

  Fly  1322 ----ERQQWSFNIKTRAPVFDVDWGIEEDTKL-----LCGIYQY--------------------- 1356
                ...:|:    || .||:    :::.::|     :|....|                     
Mouse  1122 RAENHMSRWA----TR-DVFE----LKQFSQLPANVAVCSSKTYKTQVKANIVSPTEKDQPPSDG 1177

  Fly  1357 GIGSWEQMKLDPTLKLTDKILLNDT--------RKPQAKQLQTRAEYLLKIIKKNVE-LTKG-GQ 1411
            ||.|...:......|..|....|.|        |..:.||.:..|.|....:|:..| :|:. .:
Mouse  1178 GISSPLYVSHPVVQKKKDVYRTNHTTFIIGETPRGIRRKQFEEMASYYKLPVKEFAEQVTRATSE 1242

  Fly  1412 RRQRRPR---ASRANDAKAASQSASSTIDAKPHDGEDAAGDARTVAES--SNSQVDPSTASPHNA 1471
            .||:..|   :.:..:.|....:::|.:....|..|:...:.....||  ..:..:.||.|.:::
Mouse  1243 ERQKMLRDFYSLQHPEVKEFFVNSASELIKSVHKKEERVRNKSKEKESLLKENPSNDSTLSCYDS 1307

  Fly  1472 PATEQHGDPAKKAKKSKARSKK-------TSASDNNGNK-PMHFT-------------------- 1508
            ..........|..:....||:.       |.:||...|| |:.||                    
Mouse  1308 TNKMSQVYNRKICEGKSVRSQNHVFHREDTFSSDAEINKSPVSFTEELHSERKDHTPKDTTTVFC 1372

  Fly  1509 ANNEPRALEV-LGDLDP----SIFNECKEKMRPV-KKALKALDQPDVSLSDQDQLQHTRDCLLQI 1567
            .|:...|||. ||: .|    .:...|..:.||: |...|.::.|....:.:|.|......|..:
Mouse  1373 PNSNSEALEAELGN-SPGRQWDLTGACGSRNRPLFKLRNKRVENPGSENTPEDGLLGDTSILNDL 1436

  Fly  1568 GK-------QI--DVCLNPYAETEKKEWRSNLWYF--------VSKFTELDAKRLFKIYKHALKQ 1615
            .|       |:  :|...|.|:.::|.  .:.|..        :||.|:|       .....|..
Mouse  1437 FKSHGEGPTQLPKNVLSGPVAKAKQKP--KDFWDILNEQNDDSLSKLTDL-------AVIETLCT 1492

  Fly  1616 KAGGDGEAKGKDK 1628
            ||.....:|.||:
Mouse  1493 KAPSTSASKRKDE 1505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Chd1NP_001245851.1 CD1_tandem_CHD1-2_like 339..421 CDD:349313
CD2_tandem 454..508 CDD:349306
PLN03142 531..>1066 CDD:215601 192/707 (27%)
CDH1_2_SANT_HL1 1205..1298 CDD:465731 17/99 (17%)
DUF4208 1521..1610 CDD:464035 21/110 (19%)
Ercc6l2NP_001013626.2 Tudor_SF 17..72 CDD:470623
HepA <51..649 CDD:440319 170/539 (32%)
DEXHc_ERCC6L2 122..369 CDD:350763 78/258 (30%)
DEAH box 270..273 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..735 0/19 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 749..768 6/18 (33%)
Atypical PIP-box. /evidence=ECO:0000250|UniProtKB:Q5T890 772..783 2/10 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..811 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..891 11/57 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..948 5/31 (16%)
VIGSSK <1108..1131 CDD:464308 0/22 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1306 7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

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