DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and chd9

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_031756017.1	Gene:	chd9 / 733830	XenbaseID:	XB-GENE-1217623	Length:	2891	Species:	Xenopus tropicalis

Alignment Length:	2275	Identity:	576/2275 - (25%)
Similarity:	881/2275 - (38%)	Gaps:	640/2275 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SKQFDPGCRALNESANSI----GSDEQDD--TREEANGTDHSGSGSGSGSSGSDS----DSDSSS 66
            |.|:......||.:..|:    |:....|  |:.|.|    .|..:.:....|::    .|..:.
Frog   266 STQYSFSNNQLNHTTPSLPELTGNSAFSDIGTKHETN----QGMMNPNAELHSNNFQVVQSSHAH 326

  Fly    67 GNSSDGRSSPE------PEDKSLSVA---------GFPP--TAAAAQADSKTNGFT----DD--Q 108
            ||.:..:.|||      |:..|..:.         ||.|  .......|::|..|:    :|  |
Frog   327 GNFNRTKMSPETINFTHPDGSSTQMRHFNDHIENNGFSPLEDTLLQHVDAQTEHFSGLDPEDLLQ 391

  Fly   109 EDSSSDGSSGSDSDSDAEGPS---DQRNQSINNANTSSSL------PKPEQNE------------ 152
            ||........|.|..||...|   :.::..|..|.|...|      .:|..|.
Frog   392 EDLLKHFDEPSFSQEDANSSSNILEHQDMKITFARTQIKLQNDILGSQPHNNHHPWHLSDSNHHL 456

  Fly   153 -EEDNETEAGQQQPASDASAD--ESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEK 214
             :|:.:....|.:|.|....|  .:....||:...|:|....:::.|...|:.:..|....|..|
Frog   457 PQEEKQHCTFQGKPPSSKKTDGFRAFQRLANIKVRSASDKRPKKKVDTESKQEKANRIISEAIAK 521

  Fly   215 SK--------KAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKP---------AATTSRSK--- 259
            :|        :..:|:|       ..|..||..|::.....|.||         |..:|..|
Frog   522 AKERGERNIPRVMSPEN-------FPSVSSEGKDEKRGRKGKSKPKEKEGKKTKAGLSSELKEKK 579

  Fly   260 --------LAQQQQRRRVKPFSSEDSDDDDASKR-----------------------CATRRKGA 293
                    |.::|:|   |..||:|..|.|.:.|                       ...||...
Frog   580 KIGKLIITLGRKQKR---KMESSDDVSDSDRAPRVHNDEDLQEFAWRTDHLHQDQTGSMKRRSNR 641

  Fly   294 AVSYKEASED-EATDSEDLLEFEYDESQAATTAATAE---------EEEKCETIERILAQRAGKR 348
            .|..|:..|| |...|||..:......:.:|:....:         .||....:::|||.|..|:
Frog   642 QVKRKKYVEDVEGKQSEDEPKANVKPKKNSTSLPVEQPLQLFVENPSEEDAAIVDKILASRIAKK 706

  Fly   349 GCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGM 413
            ..:..  |...:||                      :.:|:|.:||:|..|.:|..|  :|.|.:
Frog   707 ETSSG--TFVEVEE----------------------YYVKYKNYSYLHCEWATEQQL--LKDKRI 745

  Fly   414 -KKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKS-YNNVDRIIAKGSKPDDGTEE-- 474
             :|:..|..::.::|:           :|   .:::.||..| |..|||::......|..|.|
Frog   746 HQKIKRFKIRQAQRAH-----------FF---ADMEEELFNSDYIEVDRVLEVSLCQDKDTGEPV 796

  Fly   475 --YLCKWQSLPYAESTWE-----DAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRI 532
              ||.||.||||.:||||     |.|.:        ::|...::.|  |... ||.:..|...:.
Frog   797 IYYLVKWCSLPYEDSTWELKEDVDQAKI--------DEFEQLQALK--PDAR-RVERPPPNSWKK 850

  Fly   533 KNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPF 597
            .||......|..||:||::||||||.:|....:.|||||||||||||:|.||..:: ::.:.|||
Frog   851 INQSREYKIGNQLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLQEIY-LNRIPGPF 914

  Fly   598 LCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSK------RLKFNCILTT 656
            |.:.||||:..|:|||..|. |:|||.|.|.:.||::|||||..|..|:      ..||:.|:||
Frog   915 LIIAPLSTIANWEREFRTWT-DLNVVVYHGSMISRQMIQQYEMYFRDSQGRIIWGSYKFHAIITT 978

  Fly   657 YEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALL 721
            :|::|.....|..::|..::.||||||||.:..|.:.||..:..|::|:|||||||:::||::||
Frog   979 FEMILGGCPELNAIEWRCVIFDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLL 1043

  Fly   722 HFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSL 785
            ||:.|.:|.:...|..:.|:.: ::...:|...|:|.:|||:|:||||.|..|.|.|:.||:|::
Frog  1044 HFLEPQRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKKLAPKEETIIEVELTNI 1108

  Fly   786 QKQYYKWILTKNFDALRKGK-RGSTSTFLNIVIELKKCCNHAALIRPSEFELMG--------LQQ 841
            ||:||:.||.|||..|.||. :.:....:|.::||:|||||..||:.:|.:::|        :..
Frog  1109 QKKYYRAILEKNFAFLSKGAGQANVPNLVNTMMELRKCCNHPYLIKGAEEKILGEFRETYNQMAA 1173

  Fly   842 DEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGE 906
            |..||.:::.:|||||:||||.::|..||:|||||||||.||:|.|||..:.:.::|:||.::|.
Frog  1174 DFYLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRCLDILEDYLMHKRYLYERIDGRVRGN 1238

  Fly   907 MRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQ 971
            :|:.|:|.|:...|..|.|||.||||||||||..|||.||||||||||||||||||.|||||...
Frog  1239 LRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQNKA 1303

  Fly   972 VNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHS-SNSNPFNKDDLSAI 1035
            |.:|||:|..|.|.::.:||..|:.||..|:|.|          ||..:| ......:|.::..:
Frog  1304 VKVYRLITRNSYEREMFDRASLKLGLDKAVLQSM----------SGRENSVGGIQQLSKKEIEDL 1358

  Fly  1036 LKFGAEELFKDEQEHDDDLVC--DIDEILRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDS 1098
            |:.||.....|| |.:....|  |||:||:|   |.:...:.::...|.|..||..|.......|
Frog  1359 LRRGAYGAIMDE-EDEGSKFCEEDIDQILQR---RTKTITIESEGRGSTFAKASFVASGNRTDIS 1419

  Fly  1099 VSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYL-PPR-----RKTAANQNEGKR 1157
            :           ||...|.    :..:||..|.:.......|.: .||     |..:|.::|
Frog  1420 L-----------DDPNFWQ----KWAKKAEIDIDSVSGRNSLVIDTPRIRKQTRPFSATKDE--- 1466

  Fly  1158 GAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRF-------- 1214
                      .|:.|..:|:        |:| :|:.| ||  .::..|:...|..|.
Frog  1467 ----------LAELSEAESE--------GED-KPKLR-RP--YDRANGYGRTECFRVEKNLLVYG 1509

  Fly  1215 ------IRSYKKFPAPLHRMEA-IACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAA 1272
                  |.|:.:|...|:..:. |.|.|.|.                .|:  :|...:|:.|:..
Frog  1510 WGRWRDILSHGRFKRQLNEQDVEIICRALLA----------------YCL--VHYRGDEKIKSFI 1556

  Fly  1273 TDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVF 1337
            .|.....:..|.|                      |||  |.:..|.|..|.:....:||:...|
Frog  1557 WDLITPTEDGRTR----------------------ELQ--NHLGLSAPVPRGRKGKKVKTQTSTF 1597

  Fly  1338 DVD-------------------------------------------------------------- 1340
            |:.
Frog  1598 DIHKAEWLRKHNPEHLLQDDGYKKHLKHHCNKVLLRVRMLYYLRQEVIGVYCQKVLDGVASSEID 1662

  Fly  1341 ---------------WGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQL- 1389
                           |..|.|..||.|::::|...:..::.||.|     ..|....||..|.:
Frog  1663 LWVPEPDHSELPVDWWDTEADKSLLIGVFKHGYEKYNTIRADPAL-----CFLERAGKPDEKAVA 1722

  Fly  1390 -QTRAEYLLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGD---- 1449
             :.||.   ..|..:||      ..:.:|..:...|......::...:.....||:...||
Frog  1723 AEQRAN---DFIDGDVE------DPEYKPAPTLFKDDMKDDDASPGDLIIADGDGQIMDGDKVYW 1778

  Fly  1450 ----------ARTVA----ESSNSQVD------PSTASPHNAPATEQHGDPAKKAK--------- 1485
                      .|.|.    .|...||.      |..|:..:||..|...:|...||
Frog  1779 PTQSALTTRLRRLVTAFQRTSKCKQVQLVTPVFPVQAAATHAPNEEATLNPKMAAKIERQQRWTR 1843

  Fly  1486 -----------------------------KSKAR-SKKTSAS---------------------DN 1499
                                         ::.|| .|||..|                     |.
Frog  1844 REEADFYRVVSTFGVVFDPGRGQFDWTKFRAMARLHKKTDESLEKYLYAFIAMCRRVCRLPSRDE 1908

  Fly  1500 NGNKPMHFTANNEPRALEVLGDLD------------PSIFNECKEKMRPVKKALKALDQPDVSLS 1552
            ..:..:......|.||...|..::            |.:|...|            |.||:..|.
Frog  1909 FVDSSISIQPITEERASRTLYRIELLRKVREQALRHPQLFERLK------------LCQPNPDLP 1961

  Fly  1553 DQDQL-QHTRDCLLQIGKQIDVCLNPYAETEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQK 1616
            ...:. .|.||.|:...|      :..:.|:         |.:.:..||......|.|
Frog  1962 VWWECGTHDRDLLIGAAK------HGVSRTD---------YHILRDPELSFMVTQKNY------- 2004

  Fly  1617 AGGDGEAKGKDKGSSGSPAKSKPN-------------------GVTTEE---KEKERDRSGGKKK 1659
                    .:.||:|.:|..:.||                   |.|.::   ||:.........:
Frog  2005 --------SQSKGTSSTPLLAIPNHLSITAFPLHSHSKVQDVKGFTNDDIRVKEEALKEDILTSE 2061

  Fly  1660 KKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDEN---DADASSGLAGAPGGGIGDNLKSMSF 1721
            ::....||....|..|:..||.|     |:...:::.   ..:.:..:..|....:..||.|
Frog  2062 EESASSERLKARRKIESLNPTIG-----PVFHAKEQKAVVKIETNRRMVAARTEPLTPNLTS--- 2118

  Fly  1722 KRLNMDRHEDRKKHHRGPDYYGGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAPSG 1786
            |:..:.:||.........|....|.....|.|....|:....|.:|.|:            :.|.
Frog  2119 KKQRISKHESASSSDSDSDSNRSSCSSRSSSSSTSSSSCSHSGSSSSSS------------SSSS 2171

  Fly  1787 YTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQ----GSYHRE--------RDRRPEKRRYPSGL 1839
            .:.......|....|.....|..||..:.....    .:|..|        :|...:..:..:|.
Frog  2172 CSSSTSSSSSSSSSSTSSSEDSDDGDAQKSAESVPHVKTYDEESVASVSTLQDETQDSFQMDNGT 2236

  Fly  1840 PPHPYSSHYLPPNYYGLPNGAVPGLPPP---------SSVYRSDPRG-YPVMPRDYPADYRRSDY 1894
               |.||.:||..|      .:.|...|         .|:.::..:| :|...|:|.|....|.|
Frog  2237 ---PNSSCFLPGGY------MLAGAHWPKDRVMINRLDSICQAVLKGKWPTTRRNYEATSVASFY 2292

Fly 1895 1894
Frog 2293 2292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	12/48 (25%)
		Chromo	458..509	CDD:278797	21/59 (36%)
		SNF2_N	548..829	CDD:278600	130/288 (45%)
		DEXDc	564..709	CDD:238005	68/150 (45%)
		Helicase_C	852..967	CDD:278689	73/114 (64%)
		DUF4208	1521..1610	CDD:290618	17/101 (17%)
		DUF3824	1795..>1894	CDD:289625	24/120 (20%)
chd9	XP_031756017.1	CDC27	<469..675	CDD:370537	46/215 (21%)
		CD1_tandem_CHD5-9_like	689..753	CDD:349315	21/89 (24%)
		CD2_tandem_CHD5-9_like	774..831	CDD:349310	22/64 (34%)
		PLN03142	859..>1488	CDD:215601	276/684 (40%)
		BRK	2478..2518	CDD:400080
		BRK	2552..2596	CDD:197800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910