DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Chd6

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_775544.2	Gene:	Chd6 / 71389	MGIID:	1918639	Length:	2711	Species:	Mus musculus

Alignment Length:	1591	Identity:	461/1591 - (28%)
Similarity:	697/1591 - (43%)	Gaps:	364/1591 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNFLY------HLKPDKSKQFDPGCRALNESANSIGSDEQDDTREEANGTDHSG----SGSGSGS 55
            :||.|      ...||:.:..:..........|...::|:.||......|.|:|    .|.|:|.
Mouse    28 VNFDYKSPSPFDCSPDQGENIEEAANHCLPHKNLYTTEEEADTLFSRKLTSHNGMEDSGGRGTGV 92

  Fly    56 SGSDSDSDSSSGNSSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSD 120
            .......:......:.|....||:.|.......|.....|:...:..   :.:|....||
Mouse    93 KKKRKKKEPGEQEGTKGSKDREPKPKRKREPKEPKEPRRAKEPKRAK---EPKETKQKDG----- 149

  Fly   121 SDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTS 185
                                    :.||.::.|.....|..:::..:|..           |.|.
Mouse   150 ------------------------VKKPRKHREASGTKEGKEKRSCTDYG-----------SRTK 179

  Fly   186 SSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRK 250
            |..:|.|:              .||..|:.|     |.|:|...:.||.|.:.|....|.....:
Mouse   180 SKKASREQ--------------GPTPVERKK-----KGKRKNETTVESLELDHSLPNPSLQSPEE 225

  Fly   251 P--AATTSRSKLAQQQQRRRVKPFSSEDSD----DDDASKRCATRRKGAAVSYKEASEDEATDSE 309
            |  :|.:.:.:..:|.:||:.    :||.|    |||          |..::...|....|.
Mouse   226 PSESADSQKRRSGRQVKRRKY----NEDLDFKVVDDD----------GETIAVLGAGRTSAL--- 273

  Fly   310 DLLEFEYDESQAATTAATAEE--EEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFD 372
                      .|:|.|..|||  |:....||:|||.:           |:..:       |.|
Mouse   274 ----------SASTLAWQAEEPPEDDANIIEKILASK-----------TVQEV-------HPG-- 308

  Fly   373 EKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMK-----AKGMKKLDNFIKKEKEQAYWRRY 432
               .|..:.|. |.:|::.:||:|..|   ||:.:::     |:.:|:..|      :||..:..
Mouse   309 ---EPPFDLEL-FYVKYRNFSYLHCKW---ATMEELEKDPRIAQKIKRFRN------KQAQMKHI 360

  Fly   433 AGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEE----YLCKWQSLPYAESTWE--- 490
            ....|.|.|.          ..|..:|||:......|..|.|    ||.||.||||.|||||
Mouse   361 FTEPDEDLFN----------PDYIEIDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEE 415

  Fly   491 --DAALVLRKWQRCAEQFNDRESSKCTPS-RHCRVIKYRP---KFSRIKNQPEFLSSGLTLRDYQ 549
              |.|.|        ::|   ||.:..|. :|..    ||   .:.:::...|:.:|. .||:||
Mouse   416 DVDPAKV--------KEF---ESLQILPEVKHVE----RPASDAWQKLETSREYRNSN-RLREYQ 464

  Fly   550 MDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFD 614
            ::|:||||.:|....:.|||||||||||||:|.||..:| :..::||||.:.||||:|.|:|||.
Mouse   465 LEGMNWLLFNWYNRKNCILADEMGLGKTIQSIAFLSEIF-VRGIHGPFLIIAPLSTITNWEREFR 528

  Fly   615 LWAPDMNVVTYLGDIKSRELIQQYEWQFESSKR------LKFNCILTTYEIVLKDKQFLGTLQWA 673
            .|. :||.:.|.|...||::|||||..:..::.      .||:.::||:|::|.|...|..:.|:
Mouse   529 TWT-EMNAIVYHGSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWS 592

  Fly   674 ALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQ 738
            .:::||||||||.:..|.:.||.....|::|:||||||||::||::||:|:.|.:|.:...|..:
Mouse   593 CVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEE 657

  Fly   739 HGNAE-DKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALR 802
            .|:.: ::...:|...|:|.:|||:|.||||:|..|.|.|:.||:|::||:||:.||.|||..|.
Mouse   658 FGDLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLT 722

  Fly   803 KG-KRGSTSTFLNIVIELKKCCNHAALIRPSEFELM--------GLQQDEALQTLLKGSGKLVLL 858
            || .:.:....:|.::||:|||||..||..:|.:::        ....|..||.:::.:|||||:
Mouse   723 KGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKAHSSEASDFQLQAMIQAAGKLVLI 787

  Fly   859 DKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDF 923
            ||||.:|...||:|||||||||.||:|.|||.:|.:.::|:||.::|.:|:.|:|.|....|..|
Mouse   788 DKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRF 852

  Fly   924 CFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIV 988
            .|||.||||||||||..|||.||||||||||||||||||.|||||...|.:|||:|..|.|.::.
Mouse   853 VFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMF 917

  Fly   989 ERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDD 1053
            ::|..|:.||..::|.::..|.|      ||    ....:|.::..:|:.||.....|| |.:..
Mouse   918 DKASLKLGLDKAILQDINRKGST------NG----VQQLSKMEVEDLLRKGAYGALMDE-EDEGS 971

  Fly  1054 LVC--DIDEILRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDW 1116
            ..|  |||:||:|   |.....:.::...|.|..||..|.......|:           ||...|
Mouse   972 KFCEEDIDQILQR---RTHTITIQSEGKGSTFAKASFVASGNRTDISL-----------DDPNFW 1022

  Fly  1117 DDIIPEGFRKAID-DQERAKEMEDLYL--PPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDY 1178
                 :.:.|..: |.|...|.|.|.:  |..||...:.|..:.                 |...
Mouse  1023 -----QKWAKIAELDTEANNEKESLVIDRPRVRKQTKHYNSFEE-----------------DELM 1065

  Fly  1179 ELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRF--------------IRSYKKFPAPLHR-- 1227
            |.....|..|.||.:..|  :.::...:..||..|.              |.::.:|..||:.
Mouse  1066 EFSELDSDSDERPTRSRR--LSDRARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWPLNEKD 1128

  Fly  1228 MEAIACDAEL---------QEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRR 1283
            ||.| |.|.|         .||..:.:..|.....|..||.|..|    |..:|    |..:.|:
Mouse  1129 MEMI-CRALLVYCVKHYKGDEKIKSFIWELITPSKDGQVQTLQNH----SGLSA----PVPRGRK 1184

  Fly  1284 ARATFSVKLGGVSFNAKKLLACEQEL------------QPLNEIMPSMPEERQQWSFNIKTR--- 1333
            .:.|.:..|.....||..|..|..|:            |..|:::     .|.:..:.:|..
Mouse  1185 GKKTKNQLLLPELKNADWLATCNPEVVLHDDGYKKHLKQHCNKVL-----LRVRMLYYLKAEILG 1244

  Fly  1334 ---------APVFDVD---------------WGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTD 1374
                     .|..::|               |..|.|..||.|::::|...:..|:.||.|...:
Mouse  1245 EAADKAFEGTPARELDVLLPDIDYVEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLE 1309

  Fly  1375 KILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTID-- 1437
            |:.:.|.:...|:|                .:|.|......|....:       ..||...:|
Mouse  1310 KVGMPDEKSLSAEQ----------------GVTDGTSDIPERGNIDK-------EDSAEDKLDGL 1351

  Fly  1438 ----AKPHDGEDAA-GDARTVAESSNSQVDP 1463
                |.|.||.|.. |:.:..::::....||
Mouse  1352 QKQTASPSDGSDGIFGEKKDDSQAAQDGSDP 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	13/52 (25%)
		Chromo	458..509	CDD:278797	23/59 (39%)
		SNF2_N	548..829	CDD:278600	127/288 (44%)
		DEXDc	564..709	CDD:238005	66/150 (44%)
		Helicase_C	852..967	CDD:278689	74/114 (65%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
Chd6	NP_775544.2	Required for DNA-dependent ATPase activity. /evidence=ECO:0000250	1..746		252/867 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..243		43/238 (18%)
		PTZ00449	<101..372	CDD:185628	78/402 (19%)
		CD1_tandem_CHD5-9_like	287..352	CDD:349315	21/91 (23%)
		CD2_tandem_CHD5-9_like	371..429	CDD:349310	26/68 (38%)
		PLN03142	459..>984	CDD:215601	241/537 (45%)
		DEAD-like_helicase_N	460..681	CDD:391939	95/222 (43%)
		DEAH box	597..600		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1318..1389		16/88 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1951..1978
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1997..2059
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2124..2147
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2321..2350
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2373..2419
		BRK	2402..2435	CDD:383088
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2550..2602
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2641..2711
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810