DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Chd8

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_963999.2	Gene:	Chd8 / 67772	MGIID:	1915022	Length:	2582	Species:	Mus musculus

Alignment Length:	2119	Identity:	561/2119 - (26%)
Similarity:	844/2119 - (39%)	Gaps:	594/2119 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRN 133
            ||.|.||.....|.||.:.....::.|.....|.|.|..:|:...:               .|:.
Mouse   410 SSQGASSGLSVVKVLSASEVAALSSPASCAPHTAGKTGMEENRRLE---------------HQKK 459

  Fly   134 QSINNANTSSSLPKPEQNEEED-----NETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEE 193
            |...|...:.::.:.....|::     ||.|....:|..:........||.            |.
Mouse   460 QEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSSG------------ER 512

  Fly   194 EEDYRPKRTRQARKPPTAAEKSKKAPAP---KNKKKTWDSDESD-----ESEDSDDEVSTAQKRK 250
            .::.:||:::.|....|..:.......|   |.:|:...||.||     .....:||.|:.|||:
Mouse   513 LKEEKPKKSKTAAASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSPREDEESSIQKRR 577

  Fly   251 PAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATD------SE 309
            ......|.|.             :||.|                :...:..|:|..|      .|
Mouse   578 SNRQVKRKKY-------------TEDLD----------------IKITDDEEEEEVDVTGPIKPE 613

  Fly   310 DLLEFEYDESQAATTAATA-----EEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHA 369
            .:|.....|....|..:..     ..||....::::|:.|..|
Mouse   614 PILPEPVQEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRVVK---------------------- 656

  Fly   370 GFDEKQTPDAE-TEA-QFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRY 432
                |:.|..: ||| :|.:|:|.:||:|..|   ||:..::..  |::...:|:.|.:....|:
Mouse   657 ----KELPSGQYTEAEEFFVKYKNYSYLHCEW---ATISQLEKD--KRIHQKLKRFKTKMAQMRH 712

  Fly   433 AGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEE----YLCKWQSLPYAESTWEDAA 493
            ...||.:.|.          ..|..||||:.:....|....|    ||.||.||||.:||||...
Mouse   713 FFHEDEEPFN----------PDYVEVDRILDESHSVDKDNGEPVIYYLVKWCSLPYEDSTWELKE 767

  Fly   494 LV----LRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQP------------EFLSSG 542
            .|    :|:::|             ..|||       |:..|: |:|            |:.:..
Mouse   768 DVDEGKIREFKR-------------IQSRH-------PELRRV-NRPQANAWKKLELSHEYKNRN 811

  Fly   543 LTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMT 607
             .||:||::|:||||.:|....:.|||||||||||||:|.||..::.: .::||||.:.||||:|
Mouse   812 -QLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNV-GIHGPFLVIAPLSTIT 874

  Fly   608 AWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSK-RL-----KFNCILTTYEIVLKDKQF 666
            .|:|||:.|. :||.:.|.|.:.||::|||||...:.|: ||     ||:.::||:|::|.|...
Mouse   875 NWEREFNTWT-EMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPE 938

  Fly   667 LGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDT 731
            |..::|..:::||||||||.:..|..|||..|..|::|:|||||||:::||::||||:.|.:|.:
Mouse   939 LREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPS 1003

  Fly   732 WENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILT 795
            ...|....|:.: ::...:|...|:|.:|||:|:||||:|..|.|.|:.||:|::||:||:.||.
Mouse  1004 ESEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILE 1068

  Fly   796 KNFDALRKGKRGSTS--TFLNIVIELKKCCNHAALIRPSEFELMG--------LQQDEALQTLLK 850
            |||..|.|| .|.|:  ..||.::||:|||||..||..:|.:::.        :.||..||.:::
Mouse  1069 KNFSFLSKG-AGHTNMPNLLNTMMELRKCCNHPYLINGAEEKILMEFREACHIIPQDFHLQAMVR 1132

  Fly   851 GSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHF 915
            .:|||||:||||.:||..||:|||||||||.||:|.|||.:|.:.::|:||.::|.:|:.|:|.|
Mouse  1133 SAGKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRF 1197

  Fly   916 NAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTA 980
            :...|..|.|||.||||||||||..|||.||||||||||||||||||.|||||...|.:|||:|.
Mouse  1198 SKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITR 1262

  Fly   981 RSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFK 1045
            .|.|.::.::|..|:.||..|:|.|  :||       :|:.:....|:|.::..:|:.||.....
Mouse  1263 NSYEREMFDKASLKLGLDKAVLQSM--SGR-------DGNITGIQQFSKKEIEDLLRKGAYAAIM 1318

  Fly  1046 DEQEHDDDLVC--DIDEI-LRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAA 1107
            :|.: :....|  |||:| |||..|...:.|...    |.|..||..|.|.....|:
Mouse  1319 EEDD-EGSKFCEEDIDQILLRRTTTITIESEGKG----STFAKASFVASENRTDISL-------- 1370

  Fly  1108 GEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYL--PPRRKTAANQNEGKRGAGKGGKGKQQAD 1170
               ||...|.    :..:||..|.:......:|.:  |..||...:.:..|            .|
Mouse  1371 ---DDPNFWQ----KWAKKADLDMDLLNSKNNLVIDTPRVRKQTRHFSTLK------------DD 1416

  Fly  1171 DSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELR-------------RFIRSYKKFP 1222
            |....||.|     |.||.|||.|...  :....|.||. .|             |.|.|:.:|.
Mouse  1417 DLVEFSDLE-----SEDDERPRSRRHD--RHHTYGRTDC-FRVEKHLLVYGWGRWRDILSHGRFK 1473

  Fly  1223 APL--HRMEAIACDAELQEKPLAELKRLGEMLH----DRCVQFLHE--HKEEESKTAATDETPG- 1278
            ..:  ..:|.| |.|.|          :..:||    :....|:.:  ...|..||.......|
Mouse  1474 RRMTERDVETI-CRAIL----------VYCLLHYRGDENIKSFIWDLISPAENGKTKELQNHSGL 1527

  Fly  1279 ---------AKQRRARATFSV--------------------------KLGGVSFNAKKLLACEQE 1308
                     .|:.::::||.:                          :...|....:.|....||
Mouse  1528 SIPVPRGRKGKKVKSQSTFDIHKADWIRKYNPDTLFQDESYKKHLKHQCNKVLLRVRMLYYLRQE 1592

  Fly  1309 L---QPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTL 1370
            :   |....:..::..|...| |.:..:..|....|..|.|..||.|::::|...:..|:.||.|
Mouse  1593 VIGDQAEKVLGGAIASEIDIW-FPVVDQLEVPTTWWDSEADKSLLIGVFKHGYEKYNTMRADPAL 1656

  Fly  1371 KLTDKILLNDTRKPQAKQLQTRAEYL--LKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSAS 1433
            ...:|     ..:|..|.:......|  ...:.:.::..|..:..:.:|
Mouse  1657 CFLEK-----AGRPDDKAIAAEHRVLDNFSDLVEGIDFDKDCEDPEYKP---------------- 1700

  Fly  1434 STIDAKPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHGD---PAKKAKKSKARSKKTS 1495
              :...|.|.:| .||...:.:...|.:|     ...|..|:|.|.   |...|..::.|...|:
Mouse  1701 --LQGPPKDPDD-EGDPLMMMDEEISVID-----GEEAQVTQQPGHLFWPPGSALTARLRRLVTA 1757

  Fly  1496 ASDNNGNKPMHFTA----NNEPRALEVLGDLDPSIFNECKEKMRPVK-KALKALDQPD----VSL 1551
            ...:...:.|...|    :...|..|....|        ||..|..| :.....:|.|    ||.
Mouse  1758 YQRSYKREQMKMEAAERGDRRRRRCEAAFKL--------KEIARREKQQRWTRREQTDFYRVVST 1814

  Fly  1552 ----SDQDQLQHTRD---CLLQIGKQID----------------VC-LNPYAETEKKEWRSNLWY 1592
                .|.|.:|...|   ...::.|:.|                || |.|.|..|..:  .||
Mouse  1815 FGVEYDPDNMQFHWDRFRTFARLDKKTDESLTKYFHGFVAMCRQVCRLPPAAGDEPPD--PNL-- 1875

  Fly  1593 FVSKFTELDAKR-LFKIY-----------------KHALKQKAG-----------GDGE------ 1622
            |:...||..|.| |::|.                 :.||.|..|           .|||
Mouse  1876 FIEPITEERASRTLYRIELLRRLREQVLCHPLLEDRLALCQPPGLELPKWWEPVRHDGELLRGAA 1940

  Fly  1623 --------------------------AKGKDKGSS--------------------GSPAKSKPNG 1641
                                      .:....|:|                    .||:..:|:.
Mouse  1941 RHGVSQTDCNIMQDPDFSFLAARMNYMQNHQAGASAASLSRCSTPLLHQQCTSRTASPSPLRPDA 2005

  Fly  1642 VTTEEKE--------------KERDRSGGKKKKKDKDKE-RSGQARYPETGIPTSGRYADPPLKR 1691
            ...:..|              |..|....:.:...:|.| |.|.:   :|. |.|  .:.||:|.
Mouse  2006 PVEKSPEESTVQVPNLESLTLKLEDEVVARSRLTSQDYEVRVGSS---DTA-PLS--RSVPPVKL 2064

  Fly  1692 KRDENDADASSGLAG-APGGGIGDNLKSMSFKRLNMDRHEDRKKH-----HRGPDYY-------- 1742
            : ||:|:|:...|:. :|......:..|.|   .:.|..||.|:.     ...|..|
Mouse  2065 E-DEDDSDSELDLSKLSPSSSSSSSSSSSS---SSTDESEDEKEEKLTADRSRPKLYDEESLLSL 2125

  Fly  1743 --GGSGPPMGSG-------------------------------------SYEGGSNSRRQ----- 1763
              ...|.|...|                                     |.:..||.|.|
Mouse  2126 TMSQDGFPNEDGEQMTPELLLLQERQRASEWPKDRVLINRIDLVCQAVLSGKWPSNRRSQEVTAG 2190

  Fly  1764 ---GP-----TSPS-TPRTGRGGYDPPPAP-SGYTPEMERWQ-----------SRDRYSQD---- 1803
               ||     .||| ||  |..|..|.|.| ||....|...:           ::.|...|
Mouse  2191 GILGPGNHLLDSPSLTP--GEDGDSPVPTPRSGSAASMAEEEASAVTTAAAQFTKLRRGMDEKEF 2253

  Fly  1804 -------------YKRDRYDGYGRSGGGQGSYHRERDRR 1829
                         :::.|....|..|.|...:|:::..|
Mouse  2254 TVQIKDEEGLKLTFQKHRLMANGVMGDGHPLFHKKKGNR 2292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	15/49 (31%)
		Chromo	458..509	CDD:278797	21/58 (36%)
		SNF2_N	548..829	CDD:278600	134/289 (46%)
		DEXDc	564..709	CDD:238005	70/150 (47%)
		Helicase_C	852..967	CDD:278689	75/114 (66%)
		DUF4208	1521..1610	CDD:290618	30/135 (22%)
		DUF3824	1795..>1894	CDD:289625	8/63 (13%)
Chd8	NP_963999.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..155
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..283
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..377
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..585		25/121 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..617		4/18 (22%)
		CHROMO	646..706	CDD:237991	20/90 (22%)
		Chromo	727..783	CDD:278797	21/68 (31%)
		SNF2_N	816..1103	CDD:278600	134/289 (46%)
		DEXDc	832..981	CDD:238005	70/150 (47%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03071	950..953		2/2 (100%)
		Helicase_C	1135..1249	CDD:278689	75/113 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1694..1715		6/39 (15%)
		Interaction with FAM124B. /evidence=ECO:0000255\|HAMAP-Rule:MF_03071	1791..2304		97/518 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1990..2019		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2045..2120		22/84 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2187..2233		15/47 (32%)
		BRK	2312..2356	CDD:197800
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2486..2582
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910