DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Chd1 and CHD8

DIOPT Version :9

Sequence 1:NP_001245851.1 Gene:Chd1 / 33505 FlyBaseID:FBgn0250786 Length:1900 Species:Drosophila melanogaster
Sequence 2:NP_001164100.1 Gene:CHD8 / 57680 HGNCID:20153 Length:2581 Species:Homo sapiens


Alignment Length:2009 Identity:552/2009 - (27%)
Similarity:826/2009 - (41%) Gaps:527/2009 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 SSDGRSSPEPEDKSLS---VAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSD 130
            ||.|.||.....|.||   ||.....|::|               ..|.|.:|.:.:...|   .
Human   408 SSQGASSGLSVVKVLSASEVAALSSPASSA---------------PHSGGKTGMEENRRLE---H 454

  Fly   131 QRNQSINNANTSSSLPKPEQNEEED-----NETEAGQQQPASDASADESSDSSANVSPTSSSSSS 190
            |:.|...|...:.::.:.....|::     ||.|....:|                         
Human   455 QKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRP------------------------- 494

  Fly   191 EEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKT----------WDSDESDESEDSDDEVST 245
            |||.|..|.|::...|......:|||.:.|.|.|.|:          .....:..|::||.||..
Human   495 EEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMP 559

  Fly   246 AQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATD--- 307
            ||..:....:|..|....:|.:|.|  .:||.|                :...:..|:|..|   
Human   560 AQSPREDEESSIQKRRSNRQVKRKK--YTEDLD----------------IKITDDEEEEEVDVTG 606

  Fly   308 ---SEDLLEFEYDESQAATTAATA-----EEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENG 364
               .|.:|.....|....|..:..     ..||....::::|:.|..|                 
Human   607 PIKPEPILPEPVQEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRIVK----------------- 654

  Fly   365 FDPHAGFDEKQTPDAE-TEA-QFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQA 427
                     |:.|..: ||| :|.:|:|.:||:|..|   ||:..::..  |::...:|:.|.:.
Human   655 ---------KELPSGQYTEAEEFFVKYKNYSYLHCEW---ATISQLEKD--KRIHQKLKRFKTKM 705

  Fly   428 YWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEE----YLCKWQSLPYAEST 488
            ...|:...||.:.|.          ..|..||||:.:....|....|    ||.||.||||.:||
Human   706 AQMRHFFHEDEEPFN----------PDYVEVDRILDESHSIDKDNGEPVIYYLVKWCSLPYEDST 760

  Fly   489 WEDAALV----LRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQP------------E 537
            ||....|    :|:::|             ..|||       |:..|: |:|            |
Human   761 WELKEDVDEGKIREFKR-------------IQSRH-------PELKRV-NRPQASAWKKLELSHE 804

  Fly   538 FLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVP 602
            :.:.. .||:||::|:||||.:|....:.|||||||||||||:|.||..::.: .::||||.:.|
Human   805 YKNRN-QLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNV-GIHGPFLVIAP 867

  Fly   603 LSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSK-RL-----KFNCILTTYEIVL 661
            |||:|.|:|||:.|. :||.:.|.|.:.||::|||||...:.|: ||     ||:.::||:|::|
Human   868 LSTITNWEREFNTWT-EMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMIL 931

  Fly   662 KDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMP 726
            .|...|..::|..:::||||||||.:..|..|||..|..|::|:|||||||:::||::||||:.|
Human   932 SDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEP 996

  Fly   727 DKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYY 790
            .:|.:...|....|:.: ::...:|...|:|.:|||:|:||||:|..|.|.|:.||:|::||:||
Human   997 SQFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYY 1061

  Fly   791 KWILTKNFDALRKGKRGSTS--TFLNIVIELKKCCNHAALIRPSEFELMG--------LQQDEAL 845
            :.||.|||..|.|| .|.|:  ..||.::||:|||||..||..:|.:::.        :..|..|
Human  1062 RAILEKNFSFLSKG-AGHTNMPNLLNTMMELRKCCNHPYLINGAEEKILTEFREACHIIPHDFHL 1125

  Fly   846 QTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQ 910
            |.:::.:|||||:||||.:||..||:|||||||||.||:|.|||.:|.:.::|:||.::|.:|:.
Human  1126 QAMVRSAGKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQA 1190

  Fly   911 ALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIY 975
            |:|.|:...|..|.|||.||||||||||..|||.||||||||||||||||||.|||||...|.:|
Human  1191 AIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVY 1255

  Fly   976 RLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGA 1040
            ||:|..|.|.::.::|..|:.||..|:|.|  :||       :|:.:....|:|.::..:|:.||
Human  1256 RLITRNSYEREMFDKASLKLGLDKAVLQSM--SGR-------DGNITGIQQFSKKEIEDLLRKGA 1311

  Fly  1041 EELFKDEQEHDDDLVC--DIDEI-LRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQ 1102
            .....:|.: :....|  |||:| |||..|...:.|...    |.|..||..|.|.....|:   
Human  1312 YAAIMEEDD-EGSKFCEEDIDQILLRRTTTITIESEGKG----STFAKASFVASENRTDISL--- 1368

  Fly  1103 DQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYL--PPRRKTAANQNEGKRGAGKGGKG 1165
                    ||...|.    :..:||..|.:......:|.:  |..||...:.:..|         
Human  1369 --------DDPNFWQ----KWAKKADLDMDLLNSKNNLVIDTPRVRKQTRHFSTLK--------- 1412

  Fly  1166 KQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELR-------------RFIRS 1217
               .||....||.|     |.||.|||.|...  :....|.||. .|             |.|.|
Human  1413 ---DDDLVEFSDLE-----SEDDERPRSRRHD--RHHAYGRTDC-FRVEKHLLVYGWGRWRDILS 1466

  Fly  1218 YKKFPAPL--HRMEAIACDAELQEKPLAELKRLGEMLHDRCVQ----FLHE--HKEEESKTAATD 1274
            :.:|...:  ..:|.| |.|.|          :..:||.|..:    |:.:  ...|..||....
Human  1467 HGRFKRRMTERDVETI-CRAIL----------VYCLLHYRGDENIKGFIWDLISPAENGKTKELQ 1520

  Fly  1275 ETPG----------AKQRRARATFSV--------------------------KLGGVSFNAKKLL 1303
            ...|          .|:.::::||.:                          :...|....:.|.
Human  1521 NHSGLSIPVPRGRKGKKVKSQSTFDIHKADWIRKYNPDTLFQDESYKKHLKHQCNKVLLRVRMLY 1585

  Fly  1304 ACEQEL---QPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMK 1365
            ...||:   |....:..::..|...| |.:..:..|....|..|.|..||.|::::|...:..|:
Human  1586 YLRQEVIGDQAEKVLGGAIASEIDIW-FPVVDQLEVPTTWWDSEADKSLLIGVFKHGYEKYNTMR 1649

  Fly  1366 LDPTLKLTDKILLNDTRKPQAKQLQTRAEYL--LKIIKKNVELTKGGQRRQRRPRASRANDAKAA 1428
            .||.|...:|     ..:|..|.:......|  ...|.:.|:..|..:..:.:|           
Human  1650 ADPALCFLEK-----AGRPDDKAIAAEHRVLDNFSDIVEGVDFDKDCEDPEYKP----------- 1698

  Fly  1429 SQSASSTIDAKPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHGD---PAKKAKKSKAR 1490
                   :...|.| :|..||...:.:...|.:|..     .|..|:|.|.   |...|..::.|
Human  1699 -------LQGPPKD-QDDEGDPLMMMDEEISVIDGD-----EAQVTQQPGHLFWPPGSALTARLR 1750

  Fly  1491 SKKTSASDNNGNKPMHFTA----NNEPRALEVLGDLDPSIFNECKEKMRPVK-KALKALDQPD-- 1548
            ...|:...:...:.|...|    :...|..|....|        ||..|..| :.....:|.|  
Human  1751 RLVTAYQRSYKREQMKIEAAERGDRRRRRCEAAFKL--------KEIARREKQQRWTRREQTDFY 1807

  Fly  1549 --VSL----SDQDQLQHTRD---CLLQIGKQID----------------VC-LNPYAETEKKEWR 1587
              ||.    .|.|.:|...|   ...::.|:.|                || |.|.|..|..:  
Human  1808 RVVSTFGVEYDPDTMQFHWDRFRTFARLDKKTDESLTKYFHGFVAMCRQVCRLPPAAGDEPPD-- 1870

  Fly  1588 SNLWYFVSKFTELDAKR-LFKIY-----------------KHALKQKAG-----------GDGE- 1622
            .||  |:...||..|.| |::|.                 :.||.|..|           .||| 
Human  1871 PNL--FIEPITEERASRTLYRIELLRRLREQVLCHPLLEDRLALCQPPGPELPKWWEPVRHDGEL 1933

  Fly  1623 AKG----------------------------KDKGSSGSPAKSKPNGVTTEEKEKERDRSGGK-K 1658
            .:|                            .....:|:||.|.....|....::...|:... .
Human  1934 LRGAARHGVSQTDCNIMQDPDFSFLAARMNYMQNHQAGAPAPSLSRCSTPLLHQQYTSRTASPLP 1998

  Fly  1659 KKKDKDKERSGQARYPETGI---------------------PTSGRY---------------ADP 1687
            .:.|...|:|.:    ||..                     ||...|               :.|
Human  1999 LRPDAPVEKSPE----ETATQVPSLESLTLKLEHEVVARSRPTPQDYEMRVSPSDTTPLVSRSVP 2059

  Fly  1688 PLKRKRDENDADASSGLAG-APGGGIGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSGPPMGS 1751
            |:|.: ||:|:|:...|:. :|......:..|.|   .:.|..||.|:.                
Human  2060 PVKLE-DEDDSDSELDLSKLSPSSSSSSSSSSSS---SSTDESEDEKEE---------------- 2104

  Fly  1752 GSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAPSG--YTPEMERWQSRDRYSQDYKRDR 1808
             .....|.|:.....|..:....:.|:   |...|  .|||:...|.|.|.| ::.:||
Human  2105 -KLTDQSRSKLYDEESLLSLTMSQDGF---PNEDGEQMTPELLLLQERQRAS-EWPKDR 2158

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Chd1NP_001245851.1 CHROMO 374..422 CDD:237991 15/49 (31%)
Chromo 458..509 CDD:278797 21/58 (36%)
SNF2_N 548..829 CDD:278600 134/289 (46%)
DEXDc 564..709 CDD:238005 70/150 (47%)
Helicase_C 852..967 CDD:278689 75/114 (66%)
DUF4208 1521..1610 CDD:290618 30/135 (22%)
DUF3824 1795..>1894 CDD:289625 6/14 (43%)
CHD8NP_001164100.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..392
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..582 38/195 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..615 4/18 (22%)
CHROMO 644..704 CDD:237991 20/90 (22%)
Chromo 725..781 CDD:278797 21/68 (31%)
SNF2_N 814..1101 CDD:278600 134/289 (46%)
DEXDc 830..979 CDD:238005 70/150 (47%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 948..951 2/2 (100%)
Helicase_C 1133..1247 CDD:278689 75/113 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1692..1712 5/38 (13%)
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124 1789..2302 79/403 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2116 26/149 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2189..2229
BRK 2310..2354 CDD:197800
BRK 2379..2419 CDD:197800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2481..2581
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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