DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and chd8

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001334600.1	Gene:	chd8 / 568214	ZFINID:	ZDB-GENE-030131-6320	Length:	2555	Species:	Danio rerio

Alignment Length:	2030	Identity:	539/2030 - (26%)
Similarity:	801/2030 - (39%)	Gaps:	572/2030 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RALNESANSIGSDEQDDTREEANGT----DHSGSGSGSGSSGSDSDSDSSSGNSSDGRSSPEPED 80
            |.||:.....|....|  .|.|.|.    ...|.|.|.|..||...|.|:.|
Zfish   523 RVLNQDELPAGQTSAD--LEGAGGATGAKKKGGGGVGGGGGGSKKKSPSAGG------------- 572

  Fly    81 KSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGP----SDQRNQSINNANT 141
            ..:.|                                |.|..|.|:.|    ...:::|....||
Zfish   573 AKMVV--------------------------------GGDKKSKAKTPVIPGGGSKSKSKTKLNT 605

  Fly   142 SSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQAR 206
            .:.:.|..            ::.|:||.|   ..|.|..|||.:.     |||...:.:..||.
Zfish   606 ITLVGKKR------------KRNPSSDHS---DVDLSPPVSPRTL-----EEEMSQKRRSNRQV- 649

  Fly   207 KPPTAAEKSKKAPAPKNKKKTWDSD---ESDESE-DSDDEVSTAQKRKPAATTSRSKLAQQQQRR 267
                           |.||.|.|.|   ..||.| |:|.:|:|..  .||.             .
Zfish   650 ---------------KRKKYTEDLDIKITDDEDELDADVDVTTTP--MPAV-------------G 684

  Fly   268 RVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEE 332
            .|:|..:|...:.|.                        |....::|..:.          ..||
Zfish   685 HVQPLGAELPPELDG------------------------DGLPSMQFFVEN----------PSEE 715

  Fly   333 KCETIERILAQRAGKRG-CTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIH 396
            ....:::||:.|..|:. |.|..|.:                         .:|.:|:|.:||:|
Zfish   716 DAAIVDKILSMRVTKKEVCPGQYTNV-------------------------EEFFVKYKNYSYMH 755

  Fly   397 NTWES-EATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDR 460
            ..|.| |...||      |::...:|:.|.:....|....||.:.|.          ..|..|||
Zfish   756 CEWASLEQLERD------KRIHQKLKRFKTKQAQMRNLFQEDEEPFN----------PDYVEVDR 804

  Fly   461 IIAKGSKPDDGTEE----YLCKWQSLPYAESTWE-----DAALVLRKWQRCAEQFNDRESS---- 512
            |:.:....|....|    ||.||.||||.::|||     |...|        |:|...||.
Zfish   805 ILDESHSVDKDNGEPVVYYLVKWCSLPYEDATWELKEDVDEGKV--------EEFRKIESRQPRL 861

  Fly   513 KCTPSRHCRVIKYRPKFSRIKNQPEF--LSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLG 575
            |.||         ||..|..|...|.  ..:|..||:||::|:||||.:|....:.|||||||||
Zfish   862 KRTP---------RPAASAWKKLDESTEYKNGNQLREYQLEGVNWLLFNWYNRQNCILADEMGLG 917

  Fly   576 KTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEW 640
            ||||:|..|..:|.. .:..||:.:.||||:|.|:|||..|. |||.:.|.|.:.||::|||||.
Zfish   918 KTIQSIALLSEMFSA-GVQSPFMIIAPLSTITNWEREFSNWT-DMNAIVYHGSLASRQMIQQYEM 980

  Fly   641 QFESSK------RLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDT 699
            ..:..|      ..||:.::||:|::|.|...|..:.|..:::||||||||.:..|..|||..:.
Zfish   981 YCKDDKGHLIPGAYKFDALITTFEMILSDCPELREISWRCVVIDEAHRLKNRNCKLLDSLKMLEI 1045

  Fly   700 NHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVK 763
            .|::|:|||||||:::||::||||:.|.:|.:...|..:.|:.: ::...:|...|:|.:|||:|
Zfish  1046 EHKVLLTGTPLQNTVEELFSLLHFLEPAQFPSEIEFLREFGDLKTEEQVQKLQSILKPMMLRRLK 1110

  Fly   764 KDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKG--KRGSTSTFLNIVIELKKCCNHA 826
            :||||:|..|.|.|:.||:|.:||:||:.||.:||..|..|  :..:....||.::||:|||||.
Zfish  1111 EDVEKNLAPKQETIIEVELTDVQKKYYRAILERNFSFLSMGATQNSNVPNLLNTMMELRKCCNHP 1175

  Fly   827 ALIRPSEFELMG--------LQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLD 883
            .||..:|.:::.        |..|..||.|::.:||||||||||.|||..||:|||||||||.||
Zfish  1176 YLITGAEEKIVSELREVYDPLAPDFHLQALVRSAGKLVLLDKLLPRLKAGGHKVLIFSQMVRCLD 1240

  Fly   884 VLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFD 948
            :|.|||..:.:.::|:||.::|.:|:.|:|.|:...|..|.|||.||||||||||..|||.:|||
Zfish  1241 ILEDYLIHKRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCVIFD 1305

  Fly   949 SDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVL 1013
            ||||||||||||||.|||||...|.:|||:|..|.|.:::::|..|:.||..|:|.|
Zfish  1306 SDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMLDKASLKLGLDRAVLQSM-------- 1362

  Fly  1014 DKSGNGHSS--NSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVC--DIDEIL-RRAETRNEDPE 1073
              |||..||  ....|:|.::..:|:.||.....||.: :....|  |||:|| |||.|...:.|
Zfish  1363 --SGNKESSVNGIQQFSKKEIEDLLRKGAYAAIMDEND-EGSRFCEEDIDQILQRRATTITIESE 1424

  Fly  1074 MPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEME 1138
            ...    |.|..||..|.|.....::           ||.:.|.    :..:||..|.:......
Zfish  1425 GKG----STFSKASFVASENRTDIAL-----------DDPEFWQ----KWAKKADIDMDSLNRKN 1470

  Fly  1139 DLYL-PPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEK 1202
            .|.: .||.:....|....||             .|||.     ||...||..|....|.:...:
Zfish  1471 TLVIDTPRVRKQTRQFSSLRG-------------EGGDL-----SDLDSDDDYPPHNSRQSRASR 1517

  Fly  1203 IT--------GFTD---AELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRC 1256
            .:        |.||   .|....:..:.::...|....   |...|.|:.:..:.|:..:.   |
Zfish  1518 RSDRHSGGGYGRTDCFRVEKHLLVYGWGRWRDILSHAR---CKRRLSERDVETICRVILVF---C 1576

  Fly  1257 VQFLHEHKEEESKTAATD-ETP----------------------GAKQRRARATFSVKLGGV--- 1295
            :  :|...:|..|:...: .||                      |.|.:|.:|..|..:..|
Zfish  1577 L--IHYRGDENIKSFIWELITPPENGREPQALLNHSGLSIPVPRGRKGKRVKAQSSFDVQKVEWI 1639

  Fly  1296 -SFNAKKLL-----------ACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVD-------- 1340
             .:|...||           .|.:.|..:..:.....|...:.:.::.:.|...|:|
Zfish  1640 RKYNPDSLLLDDSYRKHLKHQCNKVLLRVRMLYYLKQEVIGEHADSVLSGADARDIDIWLPEMEQ 1704

  Fly  1341 -------WGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLK 1398
                   |..|.|..||.|:|::|...:..|:.||.|...::     ..:|..:.:....:
Zfish  1705 QDVPSGWWDAEADRCLLIGVYKHGYEMYTTMRADPCLCFVER-----CGRPNEQDINAEQQ---- 1760

  Fly  1399 IIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGDARTVAE--SSNSQV 1461
              ..:.||.:||.    ..:.|...:.|.|::.|....:    :|:....|.....|  |:..||
Zfish  1761 --AADPELGEGGD----YDKYSEDPEFKPATRHAKEMYE----EGDSVNADGEICVEDRSAPMQV 1815

  Fly  1462 D-PSTASPHNAPATEQHGD----PAKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRALEVLGD 1521
            : ||:.|          .|    |...:..::.|...|:...:...:.:...|..:       ||
Zfish  1816 EGPSSGS----------SDLCYWPTSSSLTARLRRLITAYQRSYRREQLKIEAAEK-------GD 1863

  Fly  1522 LDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQH-TR--DC----------LLQIGKQIDV 1573
                      .:.|..::|.|..:     ::.|::.|. ||  :|          :.:|.|:.|.
Zfish  1864 ----------RRRRRCEQATKLKE-----IARQERQQRWTRREECDFYRVVSTFGVERIKKETDA 1913

  Fly  1574 CLNPYAETEKKEWRSNLWYFVSKFTELDAK------RLFKIYKHALKQKA---GGDGEAKGKDKG 1629
               |..:....:|..     ...|..||.|      |.||.:....::..   .|.|: :.:|..
Zfish  1914 ---PEGDEHHMDWNR-----FRSFARLDKKTDESLTRYFKCFMSMCRKVCHIRPGRGD-ESQDMS 1969

  Fly  1630 SSGSPAKSKPNGVTTEEKEKE-----------RDR---------------------SGGKKKKKD 1662
            .|.:|        .|||:...           |:|                     |.....|.|
Zfish  1970 QSLAP--------ITEERASRTLYRVTLLCRLRERVLPHPSLEERLSLAPQTSDLPSWWSIPKHD 2026

  Fly  1663 KD----KERSGQARYPETGIPTSGRYADPPLKRKRDEND------ADASSGL---------AGAP 1708
            .:    ..|.|.:| .|..|     ::||.....:...|      |.|::.:         ||..
Zfish  2027 HELLLAAARHGVSR-TELSI-----FSDPLYSFSQSRLDYLQNQQAQAAAQIHAFSQSQDPAGIK 2085

  Fly  1709 GGGIGDNLKSMSFKRL-------NMDRHED-----------RKKHHRGPDYY-----GGSGPPMG 1750
            ..|:.|..:.:..:.|       .:..|.|           :|..:.||...     ||......
Zfish  2086 EEGLEDESRLLGVEALCPSDSPAMLLSHSDSKVGIQAGWVWKKSKNNGPSERKLGGGGGGASDSD 2150

  Fly  1751 SGSYEGGSNSRRQGPTSPSTPRTGRGGYDP----------------------PPAPSGYTPEMER 1793
            |.|..|.|:|.|...:|..:     |..|.                      .|:..|..||
Zfish  2151 SDSDSGSSSSSRHSGSSDDS-----GDSDVEREQAAALKMCDGDEENSILSLTPSQEGAPPE--- 2207

  Fly  1794 WQSRDRYSQDYKRDR 1808
             ...|....|:.:||
Zfish  2208 -SLTDPLRVDWPKDR 2221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	12/48 (25%)
		Chromo	458..509	CDD:278797	21/59 (36%)
		SNF2_N	548..829	CDD:278600	126/289 (44%)
		DEXDc	564..709	CDD:238005	66/150 (44%)
		Helicase_C	852..967	CDD:278689	75/114 (66%)
		DUF4208	1521..1610	CDD:290618	21/107 (20%)
		DUF3824	1795..>1894	CDD:289625	4/14 (29%)
chd8	NP_001334600.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..653		42/212 (20%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03071	1024..1027		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1483..1525		12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1758..1779		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2512..2555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810