DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Ino80

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster

Alignment Length:	1706	Identity:	381/1706 - (22%)
Similarity:	594/1706 - (34%)	Gaps:	635/1706 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 SLPKP-EQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARK 207
            ||.|| ..:||.|:|....::....|      ||.|:.|.......||:.:......|..||:.|
  Fly    41 SLRKPLSSDEETDDEHVVKREHDVQD------SDDSSTVGVVRMKQSSKRKSRLLASKEERQSVK 99

  Fly   208 PPTAAEKSKKAPAPKNKKKTWD---SD-ESDESEDSDDE-------------------------- 242
                |:.........:::..:|   || |||:...::||
  Fly   100 ----AQLYNFNDLTSDREWLYDLLLSDTESDDPTITEDEYVQQLLREHVREQRQRKNYYKKAANA 160

  Fly   243 --------------------VSTAQKRKPAATTSR----SKLAQQQ-------QRRRVK------ 270
                                ::||..||....|.:    ::||:.|       ||||.:
  Fly   161 QYAYYGSGLLSNHDIFAERQLATAGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNM 225

  Fly   271 --PFSSE----------------DSDDDDASKRCATRRKGAAVSYKEASEDEATD--SEDLLEFE 315
              |.|.|                :::|||        ..|..|.||......|.|  .|:.:|.|
  Fly   226 GSPESGEVPPSELGKYTFGDTLPNNEDDD--------EDGGEVDYKRELASLALDYPEEEEIEEE 282

  Fly   316 YD-----ESQAA-------TTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPH 368
            .|     |.|..       ..||.|....:   |.:|::::...|        :..|:.|.   |
  Fly   283 VDVEGGTEGQVTKVRRKRKNPAALAARRRR---IWQIMSKKESGR--------LQRIKSNN---H 333

  Fly   369 ----------AGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKE 423
                      ||...|........:|.::|       ...|.::...|:|
  Fly   334 KEMLANCKRVAGMCAKVVRQRAINSQRIMK-------ETVWRAKRLTREM--------------- 376

  Fly   424 KEQAYWRRYAGPE-----------------DIDYFECQ--------LELQHELLKSYNNVDRIIA 463
              .|||:||...|                 |::..|.:        |..|.||...:  :.:.:.
  Fly   377 --LAYWKRYERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYAHF--MSKKLG 437

  Fly   464 KGSKPD----------------------DGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQF 506
            :||:.|                      |..|..|...::   ||:..:......|.:...|::.
  Fly   438 QGSEEDQLRILSQLDEETNARLAAQDDYDAGEMKLLAQEN---AEAAMQRDLDKTRAFDVFAKKK 499

  Fly   507 NDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADE 571
            ...|..:...|  ...||..|: ..:|:.|:......||:.||:.|:.||.:.:.:..|.|||||
  Fly   500 EKEEEEQAQES--VEDIKPEPR-PEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILADE 561

  Fly   572 MGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQ 636
            ||||||:|:|.||..:.:.:.::||||.:.|.||:..||:|...:.||..||.|.|....|::::
  Fly   562 MGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILR 626

  Fly   637 QYEWQFE--SSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDT 699
            |: |..:  .::...|:.::|:|::|:.|.::...::|..:::|||..:|:..|..:|.|..|..
  Fly   627 QF-WDQKHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLGFSC 690

  Fly   700 NHRLLITGTPLQNSLKELWALLHFIMP------DKFDTWENFEVQ-HG----NAEDKGYTRLHQQ 753
            .:|||::|||:|||:.|||||||||||      |:|:.|.:.::: |.    ..::|..:|||..
  Fly   691 RNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISRLHMI 755

  Fly   754 LEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTK-NFDALRKGKRGSTST------ 811
            |:|::|||:|||||..|..|:|.::...:|..||..|:.:..| ..:.|.....|||:|
  Fly   756 LKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSSSSSA 820

  Fly   812 --FLNIVIELKKCCNHAAL-----------IRPSEFELMGLQQDEAL------------------ 845
              .:|:|::.:|.|||..|           :|.:|:.:..|..:|.|
  Fly   821 SNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRFNI 885

  Fly   846 ----------------------------------------------------------------- 845

  Fly   886 FKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRFWW 950

  Fly   846 ----------------------------------------------------------------- 845

  Fly   951 KKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVI 1015

  Fly   846 ----------------------------------------------------------------- 845

  Fly  1016 RSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYVCEP 1080

  Fly   846 ----------------------------------------------------------------- 845

  Fly  1081 LSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVV 1145

  Fly   846 ---QTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEM 907
               :||:..:|||.:||.||.|||..||||||:|||.:|:|:|.:|:..|...:.|||||.|...
  Fly  1146 PDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISA 1210

  Fly   908 RRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQV 972
            ||..:..|... :..|.||||||||||||||..|||||.:||||||..|.||..||||:||..||
  Fly  1211 RRDMVADFQTR-ADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQV 1274

  Fly   973 NIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILK 1037
            .:|||:...::||:|::||::|.     .||||..:|       ||.......|  |:.:|.:|
  Fly  1275 TVYRLICKGTIEERILQRAREKS-----EIQRMVISG-------GNFKPDTLKP--KEVVSLLL- 1324

  Fly  1038 FGAEELFKDEQEHDDDLVCDIDEILRRAETRNEDPEMPA-------------DDLLSAFKVASIA 1089
                         ||:   :|:...|:.........:||             |..:....:|:.:
  Fly  1325 -------------DDE---EIEMKYRQEAKLQSSSPIPAATQSERKRRHPQKDVNMGGTTIAATS 1373

  Fly  1090 AFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAID----DQERAKEMEDLYLPPRRKTAA 1150
            | .:.|.|.|  ...::|.:....:..:|.|..|...:..    |.......::.|:|  ..|..
  Fly  1374 A-TQNPDDDV--PSCSSAAKRIKLETEEDFIDVGITSSASSVGTDSNHPTLSQETYVP--GATCV 1433

  Fly  1151 NQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSG---DD----------GRPR--KRGRPTMK 1200
            .|.|        ...:.:|....|||...||.:.|.   ||          ..||  :||||...
  Fly  1434 QQTE--------IDSENEALVVDGDSPTMLGQNESMNFLDDLSGISPMRRRHHPRGTRRGRPRGS 1490

  Fly  1201 EKITGFTDAELRRFIRSYKKFPA-PLHRMEAIACD---AELQEKPLAELK------RLGEMLHDR 1255
            .:..|...:..|....:....|| |....:|.|..   |.....||.:.:      ..|..||
  Fly  1491 TRRGGGHGSIPRVLTPTQAATPAVPATASQAAAAGTGAAAGTSSPLPQQEVSGGGDNAGVPLH-- 1553

  Fly  1256 CVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLG-GVSFNAKKLLACEQELQPLNEIMPSM 1319
                     |||.:|:.:.::||...:|.......|.. .:|...:......:.:.||...:...
  Fly  1554 ---------EEEYRTSPSGQSPGVSCKRGPGRPRSKTATPISRGTRGAPRARRPMGPLLVPLGRS 1609

  Fly  1320 PEERQQWSFNIKTRAP 1335
            |::....|....:|||
  Fly  1610 PDDTPPSSSPATSRAP 1625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	6/47 (13%)
		Chromo	458..509	CDD:278797	10/72 (14%)
		SNF2_N	548..829	CDD:278600	112/313 (36%)
		DEXDc	564..709	CDD:238005	53/146 (36%)
		Helicase_C	852..967	CDD:278689	66/114 (58%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	26/161 (16%)
		SNF2_N	538..840	CDD:278600	111/302 (37%)
		DEXDc	555..700	CDD:238005	53/145 (37%)
		Helicase_C	1156..1269	CDD:278689	66/113 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467197
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930