DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and brm

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	1642	Identity:	434/1642 - (26%)
Similarity:	655/1642 - (39%)	Gaps:	415/1642 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GSGSGSSGSDSDSDSSSGNSSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQE----- 109
            |...|..|:.......|.::......|:.:.:....||.||..:...|.:........|:
  Fly   216 GPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAP 280

  Fly   110 --DSSSDGSSGSDSDSDAEGPSD-QRNQSINNANTSSSLPKPEQNEEE-DNETEAGQQQPASDAS 170
              .....|...........||.. |:.|........|..|.||.::.: .|..:.....|:....
  Fly   281 PPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQP 345

  Fly   171 ADESSDSSANVSPT--SSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKK-----KTW 228
            ...||.....|..|  .....|:..:....|:|    :.||..      .|.||..:     |..
  Fly   346 LIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQR----QVPPAG------MPMPKPNRITTVAKPV 400

  Fly   229 DSDESDESEDSDDEVST-------AQKRKPAATTSRSKLA-------------QQQQRRRVKPFS 273
            ..|.....::.::.::.       ..:|.||..:...:|.             |:|.|......:
  Fly   401 GLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCT 465

  Fly   274 SEDSDDDDA-----SKRCATRRKGAAVSYKEASEDEATDSEDLLEF------------------- 314
            ..|:..:.|     .||  |:|:|    .:||...|..:.:..||.
  Fly   466 RRDTTLETALNIKLYKR--TKRQG----LREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHG 524

  Fly   315 ----EYDESQAATTA----------ATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGF 365
                |:..:..|..|          |.||.|:|.|. |||..:|..:         :.|.:|.|:
  Fly   525 KDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQ-ERIEKERMRR---------LMAEDEEGY 579

  Fly   366 DPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWR 430
              ....|:|:    :....||:.... .||.|..:.....:|         |...|||:|   .:
  Fly   580 --RKLIDQKK----DKRLAFLLSQTD-EYISNLTQMVKQHKD---------DQMKKKEEE---GK 625

  Fly   431 RYAGPEDIDYFECQLELQHELLKS--YNNVDR--IIA----------KGSK--PDDGTE-EYLCK 478
            |.            ::.:.|||.|  |..:|.  |:|          .|.|  .||... ::|.:
  Fly   626 RL------------IQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHR 678

  Fly   479 WQSL---------------------PYAE---STWEDAALVLRKWQRCAEQFNDRESSKCTPSRH 519
            |.::                     |..|   :..|||.      .:.....||.::........
  Fly   679 WLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDAT------DKAQATGNDEDAKDLITKAK 737

  Fly   520 CRVIKYRPK-----------FSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMG 573
            ....:||.:           ..::..|...:.:| ||::||:.||.||:..:....:.|||||||
  Fly   738 VEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNG-TLKEYQIKGLEWLVSLYNNNLNGILADEMG 801

  Fly   574 LGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQY 638
            ||||||||..:..|.....:.||:|.:|||||:..|..||:.|||.:.||:|.|..:.|.|:|
  Fly   802 LGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ-- 864

  Fly   639 EWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLK-EFDTNHR 702
                ...:..|||.:|||||.|:|||..|..:||..:::||.||:||....|.:.|. .:...:|
  Fly   865 ----NQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYR 925

  Fly   703 LLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNA------------EDKG---YTRLHQ 752
            ||:|||||||.|.||||||:|::|..|.:...|| |..||            |::.   ..|||:
  Fly   926 LLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFE-QWFNAPFATTGEKVELNEEETILIIRRLHK 989

  Fly   753 QLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNF---DALRKGK--RGSTSTF 812
            .|.|::|||:||:||..||.|||.|::.:|::||:..||.:.:|..   |...|||  :|.....
  Fly   990 VLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKAL 1054

  Fly   813 LNIVIELKKCCNHAALIRPSEFELMGLQQDEALQT---LLKGSGKLVLLDKLLCRLKETGHRVLI 874
            :|.:::|:|.|||..:.:..|.:.........:.:   |.:.|||..|||::|.:||.|.||||:
  Fly  1055 MNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLL 1119

  Fly   875 FSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLA 939
            |.||.:.:.::.|||..|.|.:.||||:.|.|.|.:.|..|||:||..|.|||||||||||:||.
  Fly  1120 FCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQ 1184

  Fly   940 TADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQR 1004
            |||||:||||||||..|||||.|||||||:|:|.:.||:|..||||:|:..|:.|:.:|..|||
  Fly  1185 TADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ- 1248

  Fly  1005 MDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILRRAETRN 1069
                 ..:.|:...|  |....|    |..||             |.||            ....
  Fly  1249 -----AGMFDQKSTG--SERQQF----LQTIL-------------HQDD------------NEEE 1277

  Fly  1070 EDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERA 1134
            |:.|:|.|::::..    ||..|||                          .|.|::.  |.||.
  Fly  1278 EENEVPDDEMINMM----IARSEEE--------------------------IEIFKRM--DAERK 1310

  Fly  1135 KEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTM 1199
            ||.|:::  |.|:...:::|......|.       ||......|:...|        ...||.:.
  Fly  1311 KEDEEIH--PGRERLIDESELPDWLTKD-------DDEVERFHYQYDED--------TILGRGSR 1358

  Fly  1200 KEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHK 1264
            :.|...:||:                           |.||..  ||.:     |...:|..|.:
  Fly  1359 QRKEVDYTDS---------------------------LTEKEW--LKAI-----DDGAEFDEEEE 1389

  Fly  1265 EEES----------KTAATDETPGAKQRRARATFSVKLGGVSFNAKK--------LLACEQELQP 1311
            |::|          |..:.|::...|:||.:        .:...:||        ::...|:.:.
  Fly  1390 EDDSKRKRRKRKNRKEESDDDSLILKRRRRQ--------NLDKRSKKQMHKIMSAVIKHNQDGRT 1446

  Fly  1312 LNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIE--EDTKLLCGIYQYGIGSWEQMKLDPTLKLTD 1374
            |:|....:|..::...:....:.|| |:...::  ||.|.                  ..|...:
  Fly  1447 LSEPFMKLPSRQRLPDYYEIIKRPV-DIKKILQRIEDCKY------------------ADLNELE 1492

  Fly  1375 KILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQRRQRRPRASRA------NDAKAASQSAS 1433
            |..:...:..|....:....||..|..:.|.:   |.|::....|..|      |..:|.....|
  Fly  1493 KDFMQLCQNAQIYNEEASLIYLDSIALQKVFV---GARQRITAAADAAAVAAGDNTGEAHGNGGS 1554

  Fly  1434 STIDAKPHDGEDAAGDARTVAESSNSQV------DPSTASPHNAPATEQHGD---------PAKK 1483
            ...|....||.|...|...:|.:|.:.|      :.|.||   ||||.....         .:||
  Fly  1555 DNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLAS---APATPTQSSSNVSSGAATTSKK 1616

  Fly  1484 AKKSKARSKKTSASDNN 1500
            ..:.|...||.:.||::
  Fly  1617 QTRRKRSQKKYTISDDD 1633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	8/47 (17%)
		Chromo	458..509	CDD:278797	15/89 (17%)
		SNF2_N	548..829	CDD:278600	127/301 (42%)
		DEXDc	564..709	CDD:238005	65/145 (45%)
		Helicase_C	852..967	CDD:278689	71/114 (62%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903	28/148 (19%)
		HSA	501..573	CDD:214727	15/81 (19%)
		BRK	649..693	CDD:197800	7/43 (16%)
		PHA02934	687..>824	CDD:165245	35/143 (24%)
		SNF2_N	776..1071	CDD:278600	127/301 (42%)
		DEXDc	793..932	CDD:238005	65/144 (45%)
		Helicase_C	1097..1212	CDD:278689	71/114 (62%)
		SnAC	1304..1375	CDD:291293	22/118 (19%)
		Bromo_SNF2L2	1425..1530	CDD:99947	21/126 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467187
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840