DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and CG4049

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_611885.3	Gene:	CG4049 / 37860	FlyBaseID:	FBgn0034976	Length:	1669	Species:	Drosophila melanogaster

Alignment Length:	2053	Identity:	385/2053 - (18%)
Similarity:	635/2053 - (30%)	Gaps:	806/2053 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 PSDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEE 192
            |.|.| :..:||:|... .:|:|:.::..| :..:|.|.....:.:.........|........:
  Fly    40 PDDPR-RYFHNASTDPQ-HQPQQHPQQQPE-QHPEQHPQHPLHSQQQPQQHPQQQPQQHPQQQTQ 101

  Fly   193 EEEDYRPKRTRQAR-KPP------TAAEKSKKAPA--PKNKKKTWDSDESDE-----SEDSDDEV 243
            :....:|::..||: :||      |..|.:.:.|.  |:...:|....|.|.     :|.:.:.|
  Fly   102 QPPQLQPQQHPQAQIQPPIPVPISTPMEGTMEVPVKMPEYCPETSQPVEPDRVINPLAEVAKNTV 166

  Fly   244 STAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDS 308
            ....|||.:|                       .:|..|:|:         :|...|.|.:.:..
  Fly   167 PYGHKRKNSA-----------------------GEDQAANKK---------LSMAAAEEKKNSHL 199

  Fly   309 EDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGN--QTTIYAI----EENGFD- 366
            ...:....:|:...||...|:.||. |.:.|:..|:...|.....  ...|:.|    |..|.:
  Fly   200 RKNIRDVMNENNLDTTTLAAQREES-ERLARVAGQQKSMREIQKQVVHKQIFRILQLDESEGIES 263

  Fly   367 ----------PHAGFDEKQ----TPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKG----- 412
                      |...|.|::    |.|....:..               |..::.|:..||
  Fly   264 CAVANPVEHHPPVDFPEEEIASDTFDDSNSSSL---------------SGGSIEDVLHKGASVQP 313

  Fly   413 --MKKLDN-------FIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVD---RIIAKG 465
              :..:|:       .:.:|:|:      ...||::..:........:...||..|   :::...
  Fly   314 SEVVTIDDSSDDDCILLSEEEEE------EDDEDLNESDDATNSGMHVKDIYNVPDENGQVVVNM 372

  Fly   466 SKPDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFS 530
            :.|:.....||.                                                 |:.:
  Fly   373 AHPEGEETLYLA-------------------------------------------------PQIA 388

  Fly   531 RIKNQPEFLSSGLTLRDYQMDGLNWL----LHSWCKEN-----SVILADEMGLGKTIQTICFLYS 586
            ::            ::.:|:.|:.:|    :.|..:.|     ..|||..||||||:|.:.|. .
  Fly   389 KV------------IKPHQIGGVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFC-D 440

  Fly   587 LFKIHHLYGPFLCVVPLSTMTAWQREFDLWAP----DMNV------VTYLGDIKSRELIQQ---- 637
            :|..|......|||:|::|:..|..||::|.|    |.||      :..|.| :.:.|..:
  Fly   441 IFLRHTSAKTVLCVMPINTLQNWLSEFNMWIPRYSTDSNVRPRNFDIFVLND-QQKTLTARAKVI 504

  Fly   638 YEWQFESSKRLKFNCILTTYEI-------VLKDKQFLGT---------------LQWAAL----- 675
            ..|..:.      ..:|..||:       ::|.::..|:               |.:.||
  Fly   505 LNWVHDG------GVLLIGYELFRLLALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGP 563

  Fly   676 ---LVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENF-- 735
               :.||.||:||..:.:..:|||..|..|:::||.||||:|.|.|.::.|:.|:...|...|
  Fly   564 DLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCN 628

  Fly   736 ----EVQHGNAED-----------KGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSL 785
                .:|:|...|           :.:. ||..|..::.||....::.:||.|.|.::.|:||:.
  Fly   629 MFERPIQNGQCVDSTPDDIKLMRYRAHV-LHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAF 692

  Fly   786 QKQYYKWILTKNFDALRKGKRGSTSTFLNIVIELKKCC---NH---------------------- 825
            |::.|...:|   |.:|      |..|.|.:.....||   ||
  Fly   693 QRKLYDTFMT---DVVR------TKAFPNPLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEE 748

  Fly   826 ------AALIRPSEFELMGLQQ------------------------------------------- 841
                  ..::.||....:.|..
  Fly   749 VTKGAATPIVEPSADSSLSLASPLEKKINGSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNK 813

  Fly   842 -----DEALQTL------------------------------------------LKGSGKLVLLD 859
                 ||..:.|                                          :.||.::|.||
  Fly   814 SPSFYDEKPEPLNYGSFGSEGKNNYWMDSSILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLD 878

  Fly   860 --------------------------------------------------KLL------------ 862
                                                              |||
  Fly   879 TNEIKTVETTIQAPCSNNQLDNGCNAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCS 943

  Fly   863 ------------------------CRLKET---GHRVLIFSQMVRMLDVLADYLQKRHFP----- 895
                                    |.|||:   |.|:|:|||.:..|::|..||:..:.|
  Fly   944 WAVDLMKNYVSGLISNSPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQL 1008

  Fly   896 ------FQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQ 954
                  :.|||||...:.|.:.::.|||..:... ||:|||||.|||||..|:.|||||:.|||.
  Fly  1009 WTKNSSYFRLDGSTSSQERERLVNEFNANSNVKL-FLISTRAGSLGINLTGANRVIIFDASWNPC 1072

  Fly   955 NDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNG 1019
            :|.||..|.:|.||.....:||:|..|.:|::|.:|.          |::...:.|.|.:.:...
  Fly  1073 HDTQAVYRIYRYGQTKPCFVYRIVMDRCLEKKIYDRQ----------IKKQGMSDRIVDECNPEA 1127

  Fly  1020 HSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILRRAETRNEDPEMPADDLLSAFK 1084
            |.|      ..|::.:.           |::|.|     ::.:........|...|.
  Fly  1128 HLS------MKDITNLC-----------QDYDSD-----EDTVEEVNKSTGDLSKPG-------- 1162

  Fly  1085 VASIAAFEEEPSDSVSK-----QDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPP 1144
                     .||:..||     ...||:.:.::          |..|.:|||...|........|
  Fly  1163 ---------SPSEEGSKPGSANMSPNASNKSNN----------GPTKPLDDQNTPKSPNGASHSP 1208

  Fly  1145 RRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKE------KI 1203
             .||..|.            |::.|....|..:..|      |..|......|.|.|      |.
  Fly  1209 -IKTEKND------------GQEHAVHVDGIINTIL------DMHRHCVTKEPFMHESLLVDQKD 1254

  Fly  1204 TGFTDAELRRFIRSY---------KKF---PAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRC 1256
            ...:.||.|:..|||         ::|   ||.:: .:.:..|..:..||:
  Fly  1255 RKLSQAEKRQAHRSYELEKKAAVNQRFTYAPAKMN-YKIVNNDGTVITKPM-------------- 1304

  Fly  1257 VQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPE 1321
                    .::.||..:..|.|...|...|....:.|         :..::...||:.::|:...
  Fly  1305 --------NQQIKTNTSSSTGGRSTRWIPADVWQRQG---------MTAQEMTLPLDVVIPTNSA 1352

  Fly  1322 ERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKIL-LNDTRKPQ 1385
            ::.........|..|.          |...|||         |:||     :.||: :..|.|.:
  Fly  1353 DKANIILKAGQRVMVL----------KSAKGIY---------MQLD-----SGKIIAIRTTAKTE 1393

  Fly  1386 AKQLQTRAEYLLKIIKKN----VELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDA 1446
            .:             |.|    :::|..|.....:|: |...|.|      ..|.|.:|
  Fly  1394 PE-------------KTNKDDVIDITDDGDTDTTKPQ-SPEEDVK------DLTADDEP------ 1432

  Fly  1447 AGDARTVAESSNSQVDPSTASPHNAPATEQHGDPAKKAKKSKARSKKTSASDNNGNKPMHFTANN 1511
                |.|   .|.:.:|:|.|....||.::......:..||:.:...|.|:..|.::.......:
  Fly  1433 ----RVV---KNKESNPATTSRPEMPAKDRKSTENVQHFKSQTQPNTTLATTTNQHQLPSDLTYS 1490

  Fly  1512 EPRALEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLN 1576
            :|:                           ::..||....|.|...|..               .
  Fly  1491 QPQ---------------------------QSHQQPQQQASQQQPAQQP---------------P 1513

  Fly  1577 PYAETEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGKDKGSSGSPAKSKPNG 1641
            |.|                             |||.....|.|:|.:.. :......|....|..
  Fly  1514 PPA-----------------------------YKHQNHLPAAGEGYSNA-NSIQPNVPLPPHPGA 1548

  Fly  1642 VTTEEKEKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGLAG 1706
            ..:.|.....|.|..:.|        ..|..||    |....|.|...|              :.
  Fly  1549 PNSSEAPPPADSSYFQPK--------PFQHTYP----PQYYDYYDNKHK--------------SA 1587

  Fly  1707 APGGGIGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSGPPMGSGSYEGGSNS-------RRQG 1764
            .||.|...| ...|:..||.            ..|:....||   .||.|..:|       .||.
  Fly  1588 PPGSGYHIN-NYTSYGNLNF------------APYHSNLHPP---ASYIGAPSSYVNSNVFPRQH 1636

  Fly  1765 -----PTSPSTPRTGRGGYDPPPAPSGYTPEMERWQSR 1797
                 .:||::..:.|     .|:..|.|..:..|.|:
  Fly  1637 WSSVVNSSPASSESMR-----QPSYIGSTYPVNEWSSQ 1669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	7/65 (11%)
		Chromo	458..509	CDD:278797	4/53 (8%)
		SNF2_N	548..829	CDD:278600	94/381 (25%)
		DEXDc	564..709	CDD:238005	52/193 (27%)
		Helicase_C	852..967	CDD:278689	57/214 (27%)
		DUF4208	1521..1610	CDD:290618	7/88 (8%)
		DUF3824	1795..>1894	CDD:289625	1/3 (33%)
CG4049	NP_611885.3	SNF2_N	394..730	CDD:278600	94/353 (27%)
		DEXDc	420..598	CDD:238005	49/185 (26%)
		HELICc	958..1093	CDD:238034	52/135 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467220
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840