DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Etl1

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	974	Identity:	274/974 - (28%)
Similarity:	412/974 - (42%)	Gaps:	265/974 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DSSSDGSSGSDSDSDAEGP-SDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADE 173
            ||:...|:.:.:.|.|:.. ||.|...||. |.||.:..|.:.|....:...       ...||
  Fly     3 DSTVAASASASASSSAKSSLSDLRQFRINK-NASSVVASPSRTERVPGKKRI-------QVMAD- 58

  Fly   174 SSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDS---DESDE 235
             |||..|.|.|              ||:|:...   |..||.::..|.......:|:   .||..
  Fly    59 -SDSDGNDSQT--------------PKKTKLEL---TVKEKEERYMAAAKISPHFDTMAIQESLS 105

  Fly   236 SEDSDDEVSTAQKR---KPA---ATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAA 294
            ..:.|...|....|   ||.   ...::|||..:........||..|..|||..|:
  Fly   106 RTNWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNGISGGNFSDNDHSDDDDVKQ--------- 161

  Fly   295 VSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYA 359
                  |:|:..||:|      .:|:.:|.                         .||.:..::.
  Fly   162 ------SKDQVYDSDD------SDSEMSTK-------------------------MTGQRKKVFQ 189

  Fly   360 IEENGFDPHAGFDEKQTPDAETEAQFLI-----KWKGWSYIHNTWESEATLRDMKAKGMKKLDNF 419
                 |...|...|.|:....:|.:.|.     .:..||             |::    :||::.
  Fly   190 -----FMNEASLIELQSVKTLSEKKALAIIDVRPFSDWS-------------DLR----QKLESI 232

  Fly   420 IKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPY 484
                       |.:|  |:      |....||:...|.|..|:
  Fly   233 -----------RMSG--DL------LNYAQELINKQNTVAAIL---------------------- 256

  Fly   485 AESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQ 549
                                       |||. :...|:.|.....:.|..||:.|||||.|.|||
  Fly   257 ---------------------------SKCN-NMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQ 293

  Fly   550 MDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFD 614
            :.|||||.....:|.:.|||||||||||||.|.||..|.:........|.|||.||:..|:.|..
  Fly   294 IIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEIS 358

  Fly   615 LWAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIV---LKDKQFLGTLQWAALL 676
            .|.|::.|..|.|   |::..::...:|.......|:.:||||.||   .::::.....:...::
  Fly   359 RWCPELVVEKYHG---SQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLDYVI 420

  Fly   677 VDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMP--------------- 726
            .||||.|||..:..|.:|...:...|:|:|||||||:|.||.:||.|:||
  Fly   421 FDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFA 485

  Fly   727 ---------DKFDTWENFEVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEM 782
                     |:...::..::|          |..:.::|::|||:||||.|:||.|:..:.:|.|
  Fly   486 KKGKSDGDQDEVSQFQETQIQ----------RAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPM 540

  Fly   783 TSLQKQYYKWILTKNFDALRKGKRGSTS--TFLNIVIELKKCCNHAALIR--------------- 830
            :|.||.||..::  ::.:..||:..|:|  ..:.|::|:::..||..|:|
  Fly   541 SSQQKIYYHELV--DYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRL 603

  Fly   831 --------------------PSEFELMGLQQDEAL------QTLLKGSGKLVLLDKLLCRLKETG 869
                                .|:|::..:......      ..|:..|||.:.||.||.:||..|
  Fly   604 ANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEG 668

  Fly   870 HRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGL 934
            ||||:|||...|||::.:||:.|.|.|.||||:....:|:..:..||.:.| .|.|||||:|||:
  Fly   669 HRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IFVFLLSTKAGGV 732

  Fly   935 GINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLD 998
            ||||..|||.:|.|.|:||.||.||:.|.||:||:..|.||||::..::||.|:..|::|:.|:
  Fly   733 GINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLE 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	8/52 (15%)
		Chromo	458..509	CDD:278797	2/50 (4%)
		SNF2_N	548..829	CDD:278600	103/309 (33%)
		DEXDc	564..709	CDD:238005	52/147 (35%)
		Helicase_C	852..967	CDD:278689	61/114 (54%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	103/309 (33%)
		DEXDc	308..453	CDD:238005	52/147 (35%)
		Helicase_C	651..765	CDD:278689	61/114 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467151
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840