DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Marcal1

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	863	Identity:	173/863 - (20%)
Similarity:	300/863 - (34%)	Gaps:	271/863 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 SSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKR 249
            |:.||||..|:    ||...|:.....::....|||...|..|..:..:..:.:.....:..|.:
  Fly     2 STCSSSEIAEK----KRIALAKLQAKKSQLLASAPATNGKSTTSATGATQHANNGKSNPNQPQAK 62

  Fly   250 KPAATTSRSKLAQQQQRRRVKPFSSEDSDDD-----DASKRCATRR--KGAAVSYKEASEDEATD 307
            .| ....||...:|::..|..|...::....     .|.|:.:.|.  :|||..|:..:..
  Fly    63 SP-LNFYRSPTGEQKKINRSGPTPGDNKSSSFLNALKAIKQTSNRELSRGAAHPYQRPNGG---- 122

  Fly   308 SEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTT--IYAIEENGFDPH-A 369
                     :|....|.:.::::|:....:             .||..|  :|.|..:.|... :
  Fly   123 ---------NERNKPTLSLSSDKEKPVAVL-------------LGNSITCNLYLISTHRFAAQTS 165

  Fly   370 GFDE------KQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAY 428
            |:.|      |..|....:.|..|    ||:..:.::|
  Fly   166 GYHEQLVTVFKNMPTKCYDGQTRI----WSFDLSDYQS--------------------------- 199

  Fly   429 WRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAK-----GSKPDDGTEEYLCKWQSLPYAEST 488
                            |:.....||.|.:::.|..|     |..|
  Fly   200 ----------------LKTHAADLKPYVHMNGIPKKVLDLCGQPP-------------------- 228

  Fly   489 WEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQMDGL 553
                                             |:..|...:.|  :|:....   |..:|.||:
  Fly   229 ---------------------------------VVPERSVLASI--EPKLADQ---LMPFQQDGV 255

  Fly   554 NWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAP 618
            .:.:   .::..:::.||||||||.|.:. :...||..   .|.|.....||..:|.:......|
  Fly   256 CFAI---AQKGRIMICDEMGLGKTYQALA-VADYFKDD---WPLLVCTTASTRDSWAKHIMDLLP 313

  Fly   619 DM---------NVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAA 674
            .:         |...|:|:.|                     .::|:|.::.:.:..|...::..
  Fly   314 KVPIHYVQVLNNNQLYVGEAK---------------------VLITSYNMMERHEDKLMQRKFGF 357

  Fly   675 LLVDEAHRLKNDDSLLYKSLKEFDTNHR--LLITGTPLQNSLKELWALLHFIMPDKFDTWENFEV 737
            ::.||:|.|||..:....:.|......:  :|::|||..:...||:..|..| ..||..:..|..
  Fly   358 IIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMI-DGKFMNFMEFTT 421

  Fly   738 QHGNAED-------KGYTRLHQQLE-----PYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYY 790
            ::.:.:.       .|.:.| ::|:     .|:|||.|.:|...|..|..:.:.::...:
  Fly   422 RYCDGKQSTFGWDANGQSNL-EELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALV----- 480

  Fly   791 KWI---LTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAALIRPSEFELMGLQQDEA-------- 844
             |.   ..:..||..|              |||     .|..|.:|..|:......|
  Fly   481 -WTNAETKETLDAFNK--------------ELK-----TAKGRATEEILLRFYARTAEVKTRAVC 525

  Fly   845 --LQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEM 907
              |:||:|...|.::.         ..|||        |:|.::|:|......:.|:||..:.:.
  Fly   526 AYLKTLVKEQKKFIIF---------AHHRV--------MMDAISDFLSGLKVHYIRIDGQTRSDH 573

  Fly   908 RRQALDHFNAEGSQDFC--FLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKN 970
            |..::|.|..:.|   |  .|||.:|...||.|..|:.::..:.||||....||::|||||||..
  Fly   574 RSDSVDTFQKKSS---CKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTK 635

  Fly   971 QVNIYRLVTARSVEEQIV 988
            .| |.|.:.|.:..:.|:
  Fly   636 PV-ICRYLIAHNTADDII 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	7/47 (15%)
		Chromo	458..509	CDD:278797	4/55 (7%)
		SNF2_N	548..829	CDD:278600	64/306 (21%)
		DEXDc	564..709	CDD:238005	33/155 (21%)
		Helicase_C	852..967	CDD:278689	34/116 (29%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	14/101 (14%)
		DEXDc	239..420	CDD:214692	47/214 (22%)
		DEXDc	265..394	CDD:238005	33/153 (22%)
		Helicase_C	518..632	CDD:278689	38/133 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840