DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and okr

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	837	Identity:	221/837 - (26%)
Similarity:	354/837 - (42%)	Gaps:	189/837 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 CQLELQHELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPY---AESTWE--DAALVLRKW--- 499
            ||.||:.|     ..:||......:....|.|.     .||.   |.|.:|  .|.::.||:
  Fly    33 CQQELERE-----QELDRRRLGALRDASNTSEL-----PLPIRFTANSEYELAIAKVLARKFKVP 87

  Fly   500 ----------------QRCAEQ-------------------FNDRESSKCTPSRHCRVIKYRPKF 529
                            :||..:                   :.:.|.....|::....:...|..
  Fly    88 MDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVLVHVVVDPLL 152

  Fly   530 SRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKE------NSVILADEMGLGKTIQTICFLYSLF 588
            |.|            ||.:|.:|:.::..  |.|      |..|:|||||||||:|.:..:::|.
  Fly   153 SNI------------LRPHQREGVRFMYE--CVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLL 203

  Fly   589 KIHHLYGP--------FLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESS 645
            :    .||        .:.|.|.|.:..|::||..|.....:...:........|:..|....:|
  Fly   204 R----QGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTS 264

  Fly   646 KRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPL 710
            .||....:|.:||......:.|...:...::.||.|||||.|:|.|::|....|..|:|::|||:
  Fly   265 ARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPI 329

  Fly   711 QNSLKELWALLHFIMPDKFDT----WENFEVQHGNAEDKGYTRLHQQ------------LEPYIL 759
            ||.|.|.::|::|:.|:...|    ..|||......::...|...:|            ::..|:
  Fly   330 QNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCII 394

  Fly   760 RRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNF---DALRKG----KRGSTSTFLNIVI 817
            ||..:.:.|.||.|.|.::..::|::|.:.|     .||   |.:|:.    ...::.|.|..:.
  Fly   395 RRTNQILTKYLPVKFEMVICAKLTAIQLELY-----TNFLKSDQVRRSLADCNEKASLTALADIT 454

  Fly   818 ELKKCCNHAALIRPSEFELMGLQQD--EALQTLLKG-----------SGKLVLLDKLLCRLKETG 869
            .|||.|:|..||    :|.:..::.  |..|.:|..           |||.:|||.:|..::..|
  Fly   455 TLKKICSHPDLI----YEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRAEG 515

  Fly   870 H-RVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGG 933
            : :|::.|...:.||:.....:||.:.|.||||::..:.|.:.:|.||...|..|.|:||::|||
  Fly   516 NDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGG 580

  Fly   934 LGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLD 998
            .|:||..|:.:.:||.||||.||.||.||..|.|||....|||||.:.|:||:|::|...|..|
  Fly   581 CGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSL- 644

  Fly   999 HLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILR 1063
                      ..|::|   |..|:..: |.:|||..:..|.|..|    .:..|.|.|      :
  Fly   645 ----------SSTIID---NNESAEKH-FTRDDLKDLFTFDANIL----SDTHDKLKC------K 685

  Fly  1064 RAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQ-----NAAGEEDD--SKDWDDIIP 1121
            |. .:|...:.|.:|                 :|..|...|     |..|..|:  ::.|.|...
  Fly   686 RC-VQNIQMKPPPED-----------------TDCTSHLSQWYHCSNNRGLPDNILAQAWMDCKC 732

  Fly  1122 EGFRKAIDDQERAKEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDY 1178
            ..|  ....:.:|:|:    :|...:.|.:|.|.|..:.|  :....|.|...|.|:
  Fly   733 VSF--VFHHRSQAQEI----VPSAEEEATDQPEEKPESRK--RSSTPASDDSADEDF 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991
		Chromo	458..509	CDD:278797	14/93 (15%)
		SNF2_N	548..829	CDD:278600	87/317 (27%)
		DEXDc	564..709	CDD:238005	46/152 (30%)
		Helicase_C	852..967	CDD:278689	48/115 (42%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	87/317 (27%)
		DEXDc	179..328	CDD:238005	46/152 (30%)
		HELICc	493..622	CDD:238034	51/128 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467239
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840