DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Chd7

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001264078.1	Gene:	Chd7 / 320790	MGIID:	2444748	Length:	2986	Species:	Mus musculus

Alignment Length:	1927	Identity:	512/1927 - (26%)
Similarity:	800/1927 - (41%)	Gaps:	556/1927 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 SDSDSDAEGP-SDQRNQSINNANTSSS---LPKPEQNEEEDNETEAGQQQPASDASADESSD--- 176
            |.|:...|.| .|....|..||....|   ||..||..::..:.:......|.|:|.....|
Mouse   550 SPSEPFLEKPVPDMTQVSAQNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIAAGDSSKGFGKDDFP 614

  Fly   177 ---SSANVSPTSSSSSSEEEEEDYRPK-----------RTRQARKPPTAAE-----KSKKA---- 218
               .:..:...|...|.||:::..|||           :.::..|.|.|.:     |.|||
Mouse   615 GGVENQELRRNSLDVSQEEKKKKKRPKVKKDPKESKEPKEKKEPKTPKAPKIPKEPKEKKAKTVT 679

  Fly   219 PAPKNKKKTWDSDESDESEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDAS 283
            |.||:.||:       .::..|.|.|..:|:.....|..|:.:...:.....|...|| :|....
Mouse   680 PKPKSSKKS-------SNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPAPEED-EDPGVQ 736

  Fly   284 KRCATRRKGAAVSYKEASEDEATDSEDLLEF-----EYDESQAA-----TTAATAEEEEKCE--- 335
            ||.::|:    |..|..:||        |||     |.|::.||     :..:.:|::|..:
Mouse   737 KRRSSRQ----VKRKRYTED--------LEFKISDEEADDADAAGRDSPSNTSQSEQQESVDAEG 789

  Fly   336 -TIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTW 399
             .:|:|::.|..|:                        :|::.:.....:|.:|:|.:||:|..|
Mouse   790 PVVEKIMSSRLVKK------------------------QKESGEEVEVEEFYVKYKNFSYLHCQW 830

  Fly   400 ESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAK 464
               |::.|::..  |::...||:.|.:....::....:.|.|.          ..|..||||:..
Mouse   831 ---ASVEDLEKD--KRIQQKIKRFKSKQGQSKFLSEIEDDLFN----------PDYVEVDRIMDF 880

  Fly   465 GSKPDDGTE---EYLCKWQSLPYAESTWEDAALVLRK--WQRCAEQFNDRESSKCTPSRHCRVIK 524
            ....||..|   .||.||.||||.:||||     |::  .|...|:|.             :::.
Mouse   881 ARSTDDRGEPVIHYLVKWCSLPYEDSTWE-----LKQDIDQTKIEEFE-------------KLMS 927

  Fly   525 YRPKFSRIKNQP-----------EFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTI 578
            ..|:..|::..|           |:.::. .||:||::|:||||.:|....:.||||||||||||
Mouse   928 REPETERVERPPADDWKKSESSREYKNNN-KLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTI 991

  Fly   579 QTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFE 643
            |:|.|||.:: :..::||||.:.||||:..|:|||..|. ::|||.|.|...||..||.||..|:
Mouse   992 QSITFLYEIY-LKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRRTIQLYEMYFK 1054

  Fly   644 SSK------RLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHR 702
            ..:      ..||:.|:||:|::|.|...|..:.|..:::||||||||.:..|.:.||..|..|:
Mouse  1055 DPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHK 1119

  Fly   703 LLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDV 766
            :|:|||||||:::||::||||:.|.:|.:...|..:.|:.: ::...:|...|:|.:|||:|:||
Mouse  1120 VLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDV 1184

  Fly   767 EKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRK-GKRGSTSTFLNIVIELKKCCNHAALIR 830
            ||:|..|.|.|:.||:|::||:||:.||.|||..|.| |.:.:....||.::||:|||||..||.
Mouse  1185 EKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLIN 1249

  Fly   831 PSEFELM--------GLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLAD 887
            .:|.:::        ....|..||.:::.:|||||:||||.:||..||||||||||||.||:|.|
Mouse  1250 GAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILED 1314

  Fly   888 YLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWN 952
            ||.:|.:|::|:||.::|.:|:.|:|.|:...|..|.|||.||||||||||..|||.||||||||
Mouse  1315 YLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWN 1379

  Fly   953 PQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSG 1017
            ||||||||||.|||||...|.||||:|..|.|.::.::|..|:.||..|:|.|          ||
Mouse  1380 PQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSM----------SG 1434

  Fly  1018 NGHSSNS-NPFNKDDLSAILKFGAEELFKDEQEHDDDLVC--DIDEI-LRRAETRN--------- 1069
            ..:::|. ...:|.::..:|:.||.....|| |.:....|  |||:| |||..|..
Mouse  1435 RENATNGVQQLSKKEIEDLLRKGAYGALMDE-EDEGSKFCEEDIDQILLRRTHTITIESEGKGST 1498

  Fly  1070 -----------------EDP----------EMPAD-------------------DLLSAFKVASI 1088
                             :||          |:..|                   .|.||.|...:
Mouse  1499 FAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSAVKEDEL 1563

  Fly  1089 AAFEEEPSDSVSKQDQNAAGEEDDSKD--------------------WDDIIPEG-FRKAIDDQE 1132
            ..|.:..|||..|........:|.|:.                    |.||:..| :::.:.:|:
Mouse  1564 MEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQD 1628

  Fly  1133 ----------------RAKE-----MEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDS 1176
                            |..|     :.||..|    ||            .|:.:...:.||..:
Mouse  1629 VETICRAILVYCLNHYRGDENIKSFIWDLITP----TA------------DGQTRALLNHSGLSA 1677

  Fly  1177 DYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKP 1241
                          |..|||...|.|            .:|.:......|.:.:...||..||..
Mouse  1678 --------------PVPRGRKGKKVK------------AQSTQPVVHDAHWLASCNPDALFQEDS 1716

  Fly  1242 LAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLL--- 1303
            ..      :.|...|.:.|                     .|.|..:.::...:...|:|:|
Mouse  1717 YK------KHLKHHCNKVL---------------------LRVRMLYYLRQEVIGDQAEKILEGA 1754

  Fly  1304 -ACEQEL---QPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQM 1364
             :.|.::   :|.:..:|:      .|              |..|.|..||.|::::|...:..|
Mouse  1755 DSSEADVWIPEPFHAEVPT------DW--------------WDREADKSLLIGVFKHGYEKYNSM 1799

  Fly  1365 KLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGG-----QRRQRRP--RASRA 1422
            :.||.|...:::.:.|.:...|:|..|..            |..||     .|....|  :.:||
Mouse  1800 RADPALCFLERVGMPDAKAIAAEQRGTDM------------LADGGDGGEFDREDEDPEYKPTRA 1852

  Fly  1423 NDAKAASQSASSTIDAKPHDGEDAAGDARTVAESSNSQVD------PSTAS----PHNAPATEQH 1477
            .......:.|:|     |.:.::.:.:..:..:.|.|..:      |:|::    ........|
Mouse  1853 PFKDEIDEFANS-----PAEDKEESMEVHSSGKHSESNAELGQLYWPNTSTLTTRLRRLITAYQ- 1911

  Fly  1478 GDPAKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRALEVLGDLDPSIFNECKEK--------- 1533
                :..|:.:.|.:....:|....:|     ..|.||||...:   :|.:|.::|
Mouse  1912 ----RSYKRQQMRQEALMKTDRRRRRP-----REEVRALEAERE---AIISEKRQKWTRREEADF 1964

  Fly  1534 ----------MRPVK--------KALKALDQ-------------------------------PDV 1549
                      ..|||        :|...||:                               ||:
Mouse  1965 YRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLGKYFSCFVAMCRRVCRMPAKPEDEPPDL 2029

  Fly  1550 S-----LSDQ---------DQLQHTRDCLL---QIGKQIDVCLNPYAETEKKEWRSNLW------ 1591
            :     ::::         :.|:..|:.:|   |:..::.:|   ....:..||    |
Mouse  2030 ASLIEPITEERASRTLYRIELLRKIREQVLHHPQLSDRLKLC---QPSLDLPEW----WECGRHD 2087

  Fly  1592 ----------------YFVSKFTE---LDAKRLFKIYKHA-----LKQKAGGDG----------- 1621
                            |.:....|   |||.:.|...:.|     |...|.|.|
Mouse  2088 RDLLVGAAKHGVSRTDYHILNDPELSFLDAHKSFAQNRGASTVPPLNTLAMGFGQTPPVISSAHV 2152

  Fly  1622 -------EAKGKDKGSSGSPAKSKPNGVTTEEKEKERDRSGGKKKKKDKDKERS----------G 1669
                   :|:||.:....||||.:.:|     ||:|.:..|.|..|::.:.|.|          |
Mouse  2153 HEEKAMEQAEGKAEECEHSPAKERSDG-----KEEEEEAGGAKDGKQECEVEASSVKGELKGVEG 2212

  Fly  1670 QARYPETGIPTSGRYADPPLKRKRDENDADASSGLAGAPGGG 1711
            .|......:...|...|...|.:.|:...::|...|||...|
Mouse  2213 SADPGSKSVSEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRG 2254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	12/47 (26%)
		Chromo	458..509	CDD:278797	23/55 (42%)
		SNF2_N	548..829	CDD:278600	130/288 (45%)
		DEXDc	564..709	CDD:238005	68/150 (45%)
		Helicase_C	852..967	CDD:278689	77/114 (68%)
		DUF4208	1521..1610	CDD:290618	25/188 (13%)
		DUF3824	1795..>1894	CDD:289625
Chd7	NP_001264078.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..180
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..246
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..307
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..792		62/261 (24%)
		CD1_tandem_CHD5-9_like	786..850	CDD:349315	17/92 (18%)
		CD2_tandem_CHD5-9_like	869..926	CDD:349310	24/74 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..949		3/20 (15%)
		PLN03142	957..>1556	CDD:215601	257/611 (42%)
		DEAH box	1095..1098		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1566..1590		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1826..1851		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2151..2274		27/109 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2366..2393
		BRK	2552..2593	CDD:369408
		BRK	2631..2675	CDD:197800
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2812..2861
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2924..2986
		Glutenin_hmw	<23..553	CDD:367362	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..146
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810