DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Chd2

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_038968738.1	Gene:	Chd2 / 308738	RGDID:	1310056	Length:	1840	Species:	Rattus norvegicus

Alignment Length:	1943	Identity:	878/1943 - (45%)
Similarity:	1159/1943 - (59%)	Gaps:	246/1943 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 EPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRNQSINNANT 141
            :|.::.||::  |......|..|:.....:....|:|:.:|.|||.|.:|........|.:.:.:
  Rat     4 KPREEHLSLS--PCIFTWYQTFSQLTFEEEKLSHSASEEASASDSGSQSESEQGSDPGSGHGSES 66

  Fly   142 SSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQAR 206
            :||....|...|.::|:...:.||....:.::.:.....::..  ....||..:.|..:|:.::|
  Rat    67 NSSSESSESQSESESESAGSKSQPVLPEAKEKPASKKERIADV--KKMWEEYPDVYGVRRSNRSR 129

  Fly   207 KPPT------AAEKSKKAPAPK-------NKKKTWDSDES-DESEDSDDEVSTAQKRK------- 250
            :.|:      .|....::.:||       .|::.|..|.| |:.|......|.|:::|
  Rat   130 QEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQDPSEDDQEQGSSAESEAEQKKVKARRPI 194

  Fly   251 PAATTSRSKLAQQ---QQRRRVKPFSSEDSDDDDASKRCATRRKGAA-VSYKEASEDEATDSEDL 311
            |..|..:.::.:|   |:.:|.|..||:|.||||.:.:..|||:.|. ||||| .:|..|||:||
  Rat   195 PRRTVPKPQVKKQPKIQRGKRKKQESSDDDDDDDEAPKRQTRRRAAKNVSYKE-DDDFETDSDDL 258

  Fly   312 LEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQT 376
            :|.        |.....|:::..||||::|..|.||:|.||..||:||:|.|| ||...||   |
  Rat   259 IEM--------TGEGVDEQQDNSETIEKVLDSRLGKKGATGASTTVYAVEANG-DPSGDFD---T 311

  Fly   377 PDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYF 441
            ...|.|.|:|||||||||||:|||||.:|:..|.||:|||:||.|||.|...|.....|||::||
  Rat   312 EREEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDVEYF 376

  Fly   442 ECQLELQHELLKSYNNVDRII---------------AKGSKPDDGTE-EYLCKWQSLPYAESTWE 490
            .||.||..||.|.|..|:|:|               |...||....| ||||||..|||:|.:||
  Rat   377 NCQQELASELNKQYQIVERVIAVKTSKSALGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWE 441

  Fly   491 DAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFL-SSGLTLRDYQMDGLN 554
            |.||:.:|:|.|.:.|:.|.:||..|:|.|:.:|.||:|..:|.||.:| ...|.|||||::|||
  Rat   442 DEALIGKKFQSCIDSFHSRNNSKTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLN 506

  Fly   555 WLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPD 619
            ||.|||||.||||||||||||||||||.||..||..|.||||||.||||||:|:|||||::|||:
  Rat   507 WLAHSWCKSNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTSWQREFEIWAPE 571

  Fly   620 MNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLK 684
            :|||.|:||:.||..|::|||....:||||||.::|||||:||||..||::.||.|.||||||||
  Rat   572 VNVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLK 636

  Fly   685 NDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTR 749
            ||||||||:|.:|.:|||||||||||||||||||:|||||||:||:.||:||..||...:.||..
  Rat   637 NDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQS 701

  Fly   750 LHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLN 814
            ||:.|||::||||||||||||||||||||||||::|||||||||||:|:.||.||.|||||.|||
  Rat   702 LHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKALAKGTRGSTSGFLN 766

  Fly   815 IVIELKKCCNHAALIR-PSEFELMGLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQM 878
            ||:||||||||..||| |.:.|....|  |.||:|::.||||:||||||.||:|.|:||||||||
  Rat   767 IVMELKKCCNHCYLIRAPEDSERETGQ--EVLQSLIRSSGKLILLDKLLTRLRERGNRVLIFSQM 829

  Fly   879 VRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADT 943
            |||||:||:||..:|:||||||||||||:|:||||||||:||:||||||||||||||||||:|||
  Rat   830 VRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADT 894

  Fly   944 VIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTT 1008
            |:||||||||||||||||||||||||.|||||||||..:|||:|:||||:|||||||||||||||
  Rat   895 VVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTT 959

  Fly  1009 GRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKD-EQEHDDDLVCDIDEILRRAETR-NED 1071
            |||||:  .|...||||||||::|:||||||||:|||: |.|..:....|||||||.|||| ||.
  Rat   960 GRTVLE--NNSGRSNSNPFNKEELTAILKFGAEDLFKEIEGEESEPQEMDIDEILRLAETRENEV 1022

  Fly  1072 PEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKE 1136
            .....|:|||.||||:.|..|:|..           .||...||||:||||..||.::::||.||
  Rat  1023 STSATDELLSQFKVANFATMEDEEE-----------LEERPHKDWDEIIPEEQRKKVEEEERQKE 1076

  Fly  1137 MEDLYLPPR-----RKTAANQN----EGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPR 1192
            :|::|:.||     :|...|.:    |.||.|.:....:.:.||             |.||.:|:
  Rat  1077 LEEIYMLPRIRSSTKKAQTNDSDSDTESKRQAQRSSASESETDD-------------SDDDKKPK 1128

  Fly  1193 KRGRP--TMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDR 1255
            :||||  ..|:.:.||||||:||||::||||..||.|:|.||.||||.:|.:|:||||||::|:.
  Rat  1129 RRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADLKRLGELVHNS 1193

  Fly  1256 CVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMP 1320
            ||..:.|::|:..:.|:..:.||  :||..   ::|:.||..|.|.::..|:|.:.|::.:|..|
  Rat  1194 CVSAMQEYEEQLKENASEGKGPG--KRRGP---TIKISGVQVNVKSIIQHEEEFEMLHKSIPVDP 1253

  Fly  1321 EERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDT-RKP 1384
            ||::::....:.:|..|||:||:|:|::||.|||::|.|:||.:|.||.||||||||..:| :||
  Rat  1254 EEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYGNWELIKTDPELKLTDKILPVETDKKP 1318

  Fly  1385 QAKQLQTRAEYLLKIIKKNVE----LTKG--GQRRQRRPRASRANDAKAASQSASSTIDAKPH-- 1441
            |.||||||.:||||:::|.:|    :|.|  .:.::|:||..:.|.|..........:.:..|
  Rat  1319 QGKQLQTRVDYLLKLLRKGLEKKGTVTSGEEAKLKKRKPRVKKENKAPRLKDEHGLELSSPRHSD 1383

  Fly  1442 ----------DGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHGDPAKKAKKSKAR-----S 1491
                      ||.:.:...:...:..|.:......|...    ::.||..||..|.|..     .
  Rat  1384 NPSEEGEVKDDGLEKSPTKKKQKKKENKENKEKPVSSRK----DREGDKEKKKSKDKKEKVKGGD 1444

  Fly  1492 KKTSASDNNGNKPMHFTANNEPRAL--EVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQ 1554
            .|:|:.......|:|.||.:||..:  :...|||...|:.|||:|||||||||.||:||..|:.|
  Rat  1445 AKSSSKSKRSQGPVHITAGSEPVPIGEDEDDDLDQETFSICKERMRPVKKALKQLDKPDKGLNVQ 1509

  Fly  1555 DQLQHTRDCLLQIGKQIDVCLNPYAETEK-KEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAG 1618
            :||:|||.|||:||.:|..||..|:|.|. |.||.|||.|||||||.||::|.|:||.|.|:::.
  Rat  1510 EQLEHTRSCLLKIGDRIAECLRAYSEQEHIKLWRRNLWIFVSKFTEFDARKLHKLYKMAHKKRSQ 1574

  Fly  1619 GDGEAKGKDKGSSGSPAKSKPNGVTTEEKEKERDRSGGKKKKKDKDKERSGQAR----------- 1672
            .:                        ||::|:.|..||||..:   .|.||.:|
  Rat  1575 EE------------------------EEQKKKDDTLGGKKPFR---PEASGSSRDSLISQSHASH 1612

  Fly  1673 --YPE-TGIPTS----------GRYADPPLKRKRDENDADAS----------SGLAGAPGGGIGD 1714
              :|: ..:|.|          ..|:.|   .||..::||..          .|...||.||
  Rat  1613 NLHPQKPHLPASHGPQMHGHPRDTYSHP---NKRHFSNADRGDWQRERKFNYGGGNNAPWGG--- 1671

  Fly  1715 NLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSG--PPMGSGSYEGGSNSRRQGPTSPSTPRTGRGG 1777
                        |||...::|.....:||...  ....||||...:.||::.....::.|..||.
  Rat  1672 ------------DRHHQYEQHWYKDHHYGDRRHMDAHRSGSYRPNNMSRKRPYEQYNSDRDHRGH 1724

  Fly  1778 YDPPPAPSGYTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQGSYHRERDRRPEKRRYPSGLPPH 1842
            .|                ..||:..|.||.|.|.:......|..:.|..|.||....:..|...|
  Rat  1725 RD----------------YYDRHHHDSKRRRSDDFRPQNYHQQDFRRMSDHRPTMGYHGQGPSDH 1773

  Fly  1843 PYSSHYLPPNYYGLPNGAVPGLPPPSSVYRSDPRGYPVM--PRD--YPADYRRSDYER 1896
            ..|.|......|..|       .|......||||..|..  |.|  .|.|: ||..||
  Rat  1774 YRSFHTDKLGEYKQP-------MPTLHTALSDPRSPPAQKSPHDSKSPLDH-RSPLER 1823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	29/47 (62%)
		Chromo	458..509	CDD:278797	26/66 (39%)
		SNF2_N	548..829	CDD:278600	205/280 (73%)
		DEXDc	564..709	CDD:238005	102/144 (71%)
		Helicase_C	852..967	CDD:278689	97/114 (85%)
		DUF4208	1521..1610	CDD:290618	55/89 (62%)
		DUF3824	1795..>1894	CDD:289625	30/102 (29%)
Chd2	XP_038968738.1	CD1_tandem_CHD1-2_like	272..356	CDD:349313	51/87 (59%)
		CD2_tandem_CHD1-2_like	389..460	CDD:349308	27/70 (39%)
		DEXHc_CHD2	477..713	CDD:350812	159/235 (68%)
		PLN03142	481..>1034	CDD:215601	401/556 (72%)
		CDH1_2_SANT_HL1	1143..1231	CDD:408175	45/92 (49%)
		DUF4208	1484..1566	CDD:404744	51/81 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I666
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37462
Inparanoid	1	1.050	1483	1.000	Inparanoid score	I99
OMA	1	1.010	-	-		QHG54459
OrthoDB	1	1.010	-	-		D57339at2759
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		otm44923
orthoMCL	1	0.900	-	-		OOG6_102222
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1425
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840