DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Chd1

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001100935.1	Gene:	Chd1 / 308215	RGDID:	1306794	Length:	1711	Species:	Rattus norvegicus

Alignment Length:	1953	Identity:	877/1953 - (44%)
Similarity:	1142/1953 - (58%)	Gaps:	358/1953 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SDEQ---DDTREEANGTDHSGSGSGSGSSGSDSDSDSSSGNSSDGRSSPEPEDKSLSVAGFPPTA 92
            |||:   :.:.|.:...|.|||.|||||.       ||||:||||.||
  Rat     5 SDEESVRNGSGESSQSEDDSGSASGSGSG-------SSSGSSSDGSSS----------------- 45

  Fly    93 AAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSD--------------------QRNQSIN 137
                            :..|||..|||||.|.:|..||                    :.|.||.
  Rat    46 ----------------QSGSSDSDSGSDSGSQSESESDTSRENKVQAKPPKVDGAEFWKSNPSIL 94

  Fly   138 NANTSSSLPKPEQNEEEDNETEAGQQQPAS-------DASADESSD-SSANV------------- 181
            ....|:.|.|..|..:        ||:|||       |:|:.|.|| ||::|
  Rat    95 AVQRSAMLRKQTQQPQ--------QQRPASSNSGSEEDSSSSEDSDASSSDVKRKKHNDEDWQMS 151

  Fly   182 ---SPTSSSSSSEEEEE-----------DYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDE 232
               ||:.|.|.||.|:|           ||.||...::|||...: |||.......:||.    :
  Rat   152 GSGSPSQSGSDSESEDERDKSSCDGTESDYEPKNKVKSRKPQNRS-KSKSGKKILGQKKR----Q 211

  Fly   233 SDESEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSY 297
            .|.|||.||                                 ||.|:|   ||.:.|:....|||
  Rat   212 IDSSEDEDD---------------------------------EDYDND---KRSSRRQATVNVSY 240

  Fly   298 KEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEE 362
            || .|:..|||:||||...::       ....|:|:.|||||.:..|.|::|.||..|||||||.
  Rat   241 KE-DEEMKTDSDDLLEVCGED-------VPQTEDEEFETIERFMDCRVGRKGATGATTTIYAIEA 297

  Fly   363 NGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQA 427
            :| ||:|||::.:.|.   :.|:||||||||:||||||:|.||:....:|||||||:.||::|..
  Rat   298 DG-DPNAGFEKSKEPG---DVQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK 358

  Fly   428 YWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIA-KGSKPDDGTEEYLCKWQSLPYAESTWED 491
            .|.:.|.|||::|:.||.||..:|.|.|..|:|||| ...|...|..:|.||||.|||:|.:|||
  Rat   359 RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGLPDYYCKWQGLPYSECSWED 423

  Fly   492 AALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLS--SGLTLRDYQMDGLN 554
            .||:.:|:|.|.:::..|..||.||.:.|:|:|.||:|..:|.||.::.  .||.|||||::|||
  Rat   424 GALISKKFQTCIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLN 488

  Fly   555 WLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPD 619
            ||.|||||.||.|||||||||||||||.||..||..|.||||||.||||||:|:||||...||..
  Rat   489 WLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQ 553

  Fly   620 MNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLK 684
            ||.|.|||||.||.:|:.:||....:||||||.:||||||:||||.|||.|.||.:.||||||||
  Rat   554 MNAVVYLGDINSRNMIRTHEWMHPQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLK 618

  Fly   685 NDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTR 749
            ||||||||:|.:|.:|||||||||||||||||||:|||||||:||.:||:||.:||...:.||..
  Rat   619 NDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYAS 683

  Fly   750 LHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLN 814
            ||::|||::|||||||||||||||||||||:||::|||||||||||:|:.||.||.:||||.|||
  Rat   684 LHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLN 748

  Fly   815 IVIELKKCCNHAALIRP---SEFELMGLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFS 876
            |::||||||||..||:|   :||    ..:.||||.|::.||||:||||||.||:|.|:||||||
  Rat   749 IMMELKKCCNHCYLIKPPDNNEF----YNKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFS 809

  Fly   877 QMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATA 941
            |||||||:||:||:.|.|||||||||||||:|||||||||||||:||||||||||||||||||:|
  Rat   810 QMVRMLDILAEYLKYRQFPFQRLDGSIKGELRRQALDHFNAEGSEDFCFLLSTRAGGLGINLASA 874

  Fly   942 DTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMD 1006
            |||:||||||||||||||||||||||||.|||||||||..||||.|:||||:|||||||||||||
  Rat   875 DTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMD 939

  Fly  1007 TTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKD-EQEHDDDLVCDIDEILRRAETRNE 1070
            |||:||| .:|:..|| |.||||::||||||||||||||: |.|..:....||||||:||||...
  Rat   940 TTGKTVL-HTGSAPSS-STPFNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHEN 1002

  Fly  1071 DPE--MPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQER 1133
            :|.  ...|:|||.||||:.:..:|   |.:..:      .|.:||:|:|||||..|:.::::||
  Rat  1003 EPGPLTVGDELLSQFKVANFSNMDE---DDIELE------PERNSKNWEDIIPEEQRRRLEEEER 1058

  Fly  1134 AKEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPT 1198
            .||:|::|:.||.:..|.|.......|:..:.::.   ||.|      ||...:..||:|||||.
  Rat  1059 QKELEEIYMLPRMRNCAKQISFNGSEGRRSRSRRY---SGSD------SDSISERKRPKKRGRPR 1114

  Fly  1199 M--KEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLH 1261
            .  :|.|.||:|||:||||:|||||..||.|::|||.||||.:|...:|:||||::|:.||:.|
  Rat  1115 TIPRENIKGFSDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCVKAL- 1178

  Fly  1262 EHKEEESKTAATDETPGAKQRRARA-TFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQ 1325
              |:..|.|    |..|.:..:.:. ||  ::.||..|||.::|.|.||.||::.:||.||||:|
  Rat  1179 --KDSSSGT----ERAGGRLGKVKGPTF--RISGVQVNAKLVIAHEDELIPLHKSIPSDPEERKQ 1235

  Fly  1326 WSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLND-TRKPQAKQL 1389
            ::....|:|..||:|||.|:|:.||.|||:||.||||.:|:||.|.||.|||.:| .:|||||||
  Rat  1236 YTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQL 1300

  Fly  1390 QTRAEYLLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGDARTVA 1454
            ||||:||:|::.:  :|.|...:|......|:....:|....|..:|..|    |:...|
  Rat  1301 QTRADYLIKLLSR--DLAKKEAQRLSGAGGSKRRKTRAKKNKAMKSIKVK----EEIKSD----- 1354

  Fly  1455 ESSNSQVDPSTASPHNAPATEQHGDPAKKAK-KSKARSKKTSASDNNGNKPMHFTANNEPRAL-E 1517
                       :||..:..:|:..|....:| :||.||||:..||    .|:|.||:.||..: |
  Rat  1355 -----------SSPLPSERSEEEDDNVNDSKPESKDRSKKSVVSD----APVHITASGEPVPIAE 1404

  Fly  1518 VLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAETE 1582
            ...:||...|:.|||:|||||.|||.||:|:..||:::||:|||.||::||..|..||..|:..|
  Rat  1405 ESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYSNPE 1469

  Fly  1583 K-KEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGKDKGSSGSPAKSKPNGVTTEE 1646
            : |:||.|||.|||||||.||::|.|:||||:|::                            :|
  Rat  1470 QIKQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKR----------------------------QE 1506

  Fly  1647 KEKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGLAGAPGGG 1711
            .::..|::                     :.:||:....:|.::|.::..:.|.||
  Rat  1507 SQQNSDQN---------------------SNVPTTHVIRNPDMERLKENTNHDDSS--------- 1541

  Fly  1712 IGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRG 1776
             .|...|........|.|:||   |:|..|...........|:..|.:.|
  Rat  1542 -RDGYSSDRHLSQCHDHHKDR---HQGDSYKKSDSRKRPYSSFSNGKDHR--------------- 1587

  Fly  1777 GYDPPPAPSGYTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQGSYHRERDRRPE-----KRRYP 1836
                         |.:.::...||..|.::.|          :...||.|:.||.     |.|..
  Rat  1588 -------------EWDHYRQDSRYYSDREKHR----------KLDDHRSREHRPSVEGSLKDRCH 1629

  Fly  1837 SGLPPHPYSSHYLPPNYYGLPNGAVPGLPPPSSVYRSDPRGYPVMPRDYPADYR------RSDYE 1895
            |....|  |.|.:..::..          .....:....|.|..: .|:..|:|      ||..:
  Rat  1630 SDHRSH--SDHRMHSDHRS----------STEHTHHKSSRDYRYL-SDWQLDHRAASSGPRSPLD 1681

  Fly  1896 RRT 1898
            :|:
  Rat  1682 QRS 1684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	26/47 (55%)
		Chromo	458..509	CDD:278797	24/51 (47%)
		SNF2_N	548..829	CDD:278600	202/280 (72%)
		DEXDc	564..709	CDD:238005	102/144 (71%)
		Helicase_C	852..967	CDD:278689	100/114 (88%)
		DUF4208	1521..1610	CDD:290618	50/89 (56%)
		DUF3824	1795..>1894	CDD:289625	22/109 (20%)
Chd1	NP_001100935.1	CD1_tandem_CHD1-2_like	268..352	CDD:349313	38/83 (46%)
		CD2_tandem_CHD1-2_like	385..441	CDD:349308	28/56 (50%)
		DEAD-like_helicase_N	458..695	CDD:421690	154/238 (65%)
		PLN03142	462..>998	CDD:215601	383/540 (71%)
		CDH1_2_SANT_HL1	1122..1208	CDD:408175	37/87 (43%)
		PTZ00121	<1292..1574	CDD:173412	125/285 (44%)
		DUF4208	1408..1498	CDD:404744	25/91 (27%)
		PHA03420	1591..>1691	CDD:177648	10/99 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I666
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1483	1.000	Inparanoid score	I99
OMA	1	1.010	-	-		QHG54459
OrthoDB	1	1.010	-	-		D57339at2759
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		otm44923
orthoMCL	1	0.900	-	-		OOG6_102222
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1425
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840