DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and hrp3

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001342861.1	Gene:	hrp3 / 2543064	PomBaseID:	SPAC3G6.01	Length:	1388	Species:	Schizosaccharomyces pombe

Alignment Length:	1541	Identity:	526/1541 - (34%)
Similarity:	789/1541 - (51%)	Gaps:	226/1541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 SDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSS---S 190
            |.:..:.:::..|.:...|.|.:|...|...|.:::..|....|...........|.|:..   .
pombe    12 SSKAIEQLDHVQTETPNLKQEMSESPSNSGVASKRKLQSTEWLDPELYGLRRSGRTRSNPGRYVD 76

  Fly   191 EEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKPAATT 255
            .:::||..|.:.|:..:..::..:.:..   ::.....:|..|:|||..|.......|::
pombe    77 TDDQEDVFPSKHRKGTRNGSSFSRHRTI---RDLDDEAESVTSEESESDDSSYGGTPKKR----- 133

  Fly   256 SRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDSEDLLE-FEYDES 319
            ||.|.:....:..:: |||.:|             ||  |:|.|.:..|:.:.|:..| :||
pombe   134 SRQKKSNTYVQDEIR-FSSRNS-------------KG--VNYNEDAYFESFEEEEEEEMYEY--- 179

  Fly   320 QAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQ 384
                ....:||.|....|:.:|..|.                   .:.|.|    .||..:.|
pombe   180 ----ATEVSEEPEDTRAIDVVLDHRL-------------------IEGHDG----STPSEDYE-- 215

  Fly   385 FLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKE-------KEQAYWRRYAGPEDIDYFE 442
            |||||..:|::|.|||....:  ...:|.||:||.||:.       :|.....|    |||:..:
pombe   216 FLIKWVNFSHLHCTWEPYNNI--SMIRGSKKVDNHIKQVILLDREIREDPTTTR----EDIEAMD 274

  Fly   443 CQLELQHELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFN 507
            .:.|.:.|..:.|..||||:||... .||:.|||.||:.|.|...|||.::::........:.|.
pombe   275 IEKERKRENYEEYKQVDRIVAKHLN-SDGSVEYLVKWKQLLYDFCTWEASSIIEPIAATEIQAFQ 338

  Fly   508 DRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEM 572
            :||.|..:|||.......|||:.:::.||.:::.| .|||:|:.|:||:.:.|.|..:.||||||
pombe   339 EREESALSPSRGTNYGNSRPKYRKLEQQPSYITGG-ELRDFQLTGVNWMAYLWHKNENGILADEM 402

  Fly   573 GLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQ 637
            |||||:||:.||..|......:||||.||||||:.|||....|||.|||.::|||:..||::|:.
pombe   403 GLGKTVQTVAFLSYLAHSLRQHGPFLVVVPLSTVPAWQETLALWASDMNCISYLGNTTSRQVIRD 467

  Fly   638 YEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHR 702
            ||:..:.::::|||.:|||||.||||:..|..::|..:.:||||||||.:|.||::|.:|..::|
pombe   468 YEFYVDGTQKIKFNLLLTTYEYVLKDRSVLSNIKWQYMAIDEAHRLKNSESSLYEALSQFKNSNR 532

  Fly   703 LLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTR-LHQQLEPYILRRVKKDV 766
            ||||||||||:::||.||:.|:||.||:..|...::..:.|.:.|.| |.:.|:||||||:||||
pombe   533 LLITGTPLQNNIRELAALVDFLMPGKFEIREEINLEAPDEEQEAYIRSLQEHLQPYILRRLKKDV 597

  Fly   767 EKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKG-KRGSTSTFLNIVIELKKCCNHAAL-- 828
            |||||:|.|:|||||::.||..:||.|||:|:..|.:. ..||..:.||||:||||..||..|
pombe   598 EKSLPSKSERILRVELSDLQMYWYKNILTRNYRVLTQSISSGSQISLLNIVVELKKASNHPYLFD 662

  Fly   829 -IRPSEFELMGLQ--QDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQ 890
             :..|..:.:..|  :||.|:.|:..|||:|||||||.||:..|||||||||||||||:|.|||.
pombe   663 GVEESWMQKINSQGRRDEVLKGLIMNSGKMVLLDKLLSRLRRDGHRVLIFSQMVRMLDILGDYLS 727

  Fly   891 KRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQN 955
            .|.:|.|||||::...:||.::|||||..|.||.||||||||||||||.|||||||||||||||.
pombe   728 LRGYPHQRLDGTVPAAVRRTSIDHFNAPNSPDFVFLLSTRAGGLGINLMTADTVIIFDSDWNPQA 792

  Fly   956 DLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGH 1020
            ||||.||||||||||.|.:|||::..::||.::|||::||:|::.:|    :.|  |.||..|
pombe   793 DLQAMARAHRIGQKNHVMVYRLLSKDTIEEDVLERARRKMILEYAII----SLG--VTDKQKN-- 849

  Fly  1021 SSNSNPFNKDDLSAILKFGAEELFKDE--QEHDDDLVCDIDEILRRAE---TRNE--DPEMPADD 1078
             |.::.|:.::|||||||||..:||.|  |:..:|:  ::||||..||   |.|:  ...|..::
pombe   850 -SKNDKFSAEELSAILKFGASNMFKAENNQKKLEDM--NLDEILEHAEDHDTSNDVGGASMGGEE 911

  Fly  1079 LLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEME----- 1138
            .|..|:|....|       .||               ||||||...|:..::::|.:|.|
pombe   912 FLKQFEVTDYKA-------DVS---------------WDDIIPLTEREKFEEEDRLREEEEALKQ 954

  Fly  1139 DLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKI 1203
            ::.|..||                  |.:....|..:|....|:.       .||..:..:|:::
pombe   955 EIELSSRR------------------GNRPYPSSAVESPSYSGTS-------ERKSKKQMLKDEV 994

  Fly  1204 TGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEES 1268
              ..:.|:|...|:..::.:..||...|...|:|..:....:|::...|    |....:......
pombe   995 --LLEKEIRLLYRAMIRYGSLEHRYNDIVKYADLTTQDAHVIKKIAADL----VTASRKAVSAAE 1053

  Fly  1269 KTAATDETPGAKQRRA-RATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKT 1332
            |..:.|::.....|:| ..||.   |..:.||:.|:....:|..|.:.||:......|...::::
pombe  1054 KDLSNDQSNNKSSRKALLITFK---GVKNINAETLVQRLNDLDILYDAMPTSGYSNFQIPMHVRS 1115

  Fly  1333 RAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRK-------------- 1383
             ...:...||..||:.||.||.::|.|:|.:::.||.||:.|||.|.||::
pombe  1116 -VHGWSCQWGPREDSMLLSGICKHGFGAWLEIRDDPELKMKDKIFLEDTKQTDNSVPKDKENKEK 1179

  Fly  1384 --PQAKQLQTRAEYLLKI---------IKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTID 1437
              |.|..|..|.||||..         ||.:..::..|:.:.::..|:|....|...:||.. |:
pombe  1180 KVPSAVHLVRRGEYLLSALREHHQNFGIKSSPAISTNGKTQPKKQTANRRQSGKPNVKSAQK-IE 1243

  Fly  1438 AKPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHGDPAKKAKKSKARSKKTSASDNNGN 1502
            :.......|..::|....|.:::::    :|....:..|...|.|..|             ::||
pombe  1244 SATRTPSPAISESRKKPSSKDTKIE----TPSREQSRSQTASPVKSEK-------------DDGN 1291

  Fly  1503 KPMHFTANNEPRALEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQI 1567
                .:.|.|.:|             .|||.|.||:|.:|.|.:....|...:.::...:||..|
pombe  1292 ----VSLNAEQKA-------------RCKELMYPVRKHMKRLRKDSSGLGRAELVKLLTECLTTI 1339

  Fly  1568 GKQIDVCLNPYAETEKKEWRSNLWYFVSKF---TELDAKRLFKIYK 1610
            ||.|:..:|.....||...|.|||.|...|   .|:....|..:|:
pombe  1340 GKHIEKTVNDTPSEEKATVRKNLWMFACYFWPKEEVKYTSLISMYE 1385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	19/47 (40%)
		Chromo	458..509	CDD:278797	19/50 (38%)
		SNF2_N	548..829	CDD:278600	146/285 (51%)
		DEXDc	564..709	CDD:238005	76/144 (53%)
		Helicase_C	852..967	CDD:278689	86/114 (75%)
		DUF4208	1521..1610	CDD:290618	27/91 (30%)
		DUF3824	1795..>1894	CDD:289625
hrp3	NP_001342861.1	CHROMO	192..250	CDD:214605	23/84 (27%)
		Chromo	289..340	CDD:306815	19/51 (37%)
		SNF2_N	339..>895	CDD:331286	297/567 (52%)
		CHDCT2	1123..>1152	CDD:311841	13/28 (46%)
		DUF4208	1300..1384	CDD:316429	28/96 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	279	1.000	Domainoid score	I300
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	735	1.000	Inparanoid score	I90
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		otm47113
orthoMCL	1	0.900	-	-		OOG6_102222
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R569
SonicParanoid	1	1.000	-	-		X1425
TreeFam	1	0.960	-	-
	12	11.850