DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and hrp1

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_593660.1	Gene:	hrp1 / 2542363	PomBaseID:	SPAC1783.05	Length:	1373	Species:	Schizosaccharomyces pombe

Alignment Length:	1594	Identity:	527/1594 - (33%)
Similarity:	783/1594 - (49%)	Gaps:	364/1594 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 EPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRNQSINNANT 141
            |||..:..:...|.:.                ::|:.:||:.:|...               .||
pombe     2 EPEHSNYDLKNHPTSV----------------QESTLNGSAVTDPQF---------------GNT 35

  Fly   142 SSSLPKPEQNEEEDNETEAGQQQPASDASADESS--DSSANVSPTSSSSSS-----EEEEEDYR- 198
            ::||  |..|...::|.....||..|.::.|:|.  .|:||.:..||:.|:     .:..:|.|
pombe    36 TNSL--PSMNGLLNHENSFASQQSLSSSAFDDSEIVTSTANSTVVSSALSTPKIDDAQNSDDVRV 98

  Fly   199 --PKRTRQARKPP--------------TAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQ 247
              .:|:.:|::|.              ...:|.|..||||.||..     :.:.||:.|:.....
pombe    99 DGTRRSSRAKRPVYRDFSYTEIDEHEIPIPKKRKSKPAPKQKKSV-----ASDDEDAYDKRHRFS 158

  Fly   248 KRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEAS-----EDEATD 307
            ....:.|..|:.|...                           ||.:|:|.|..     |||..:
pombe   159 INSASGTEIRTSLRSS---------------------------KGKSVNYNEQEFYDDFEDEEEE 196

  Fly   308 SEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFD 372
            .|:.:|.||:                 ..|:.:|..|  ||.
pombe   197 VEEQVEEEYE-----------------PIIDFVLNHR--KRA----------------------- 219

  Fly   373 EKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGP-- 435
            :.|..|.::..|:||||:..|::|||||..:||..:  :|.||:||:||  :...|.|.....
pombe   220 DAQDDDPKSSYQYLIKWQEVSHLHNTWEDYSTLSSV--RGYKKVDNYIK--QNIIYDREIREDPT 280

  Fly   436 ---EDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPYAESTWEDAALVLR 497
               |||:..:.:.|.::.|.:.|..|:||:|..:. ::|..||..||:.|||...|||||.::..
pombe   281 TTFEDIEALDIERERKNMLFEEYKIVERIVASETN-EEGKTEYFVKWRQLPYDNCTWEDADVIYS 344

  Fly   498 KWQRCAEQFNDRESSKCTPSRHCRVIKY--RPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSW 560
            .......||..||:|...|.:.   :.|  ||.:.:::.||.::..| .:||:|:.|:||:.:.|
pombe   345 MAPNEVYQFLQRENSPYLPYKG---VFYNTRPPYRKLEKQPSYIKGG-EIRDFQLTGINWMAYLW 405

  Fly   561 CKENSVILADEMGLGKTIQTICFLYSLFKIHHL--YGPFLCVVPLSTMTAWQREFDLWAPDMNVV 623
            .:..:.|||||||||||:||:|||..|  :|.|  :||||.||||||:.|||.....|.||:|.:
pombe   406 HRNENGILADEMGLGKTVQTVCFLSYL--VHSLKQHGPFLIVVPLSTVPAWQETLANWTPDLNSI 468

  Fly   624 TYLGDIKSRELIQQYEWQFE-SSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDD 687
            .|.|:.:||..|::||:... :|::||||.:|||||.:|||||.|..::|..|.:||||||||.:
pombe   469 CYTGNTESRANIREYEFYLSTNSRKLKFNILLTTYEYILKDKQELNNIRWQYLAIDEAHRLKNSE 533

  Fly   688 SLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTR-LH 751
            |.||::|.:|.|.:|||||||||||:||||.:|::|:||.||...:.......|||.:...| |.
pombe   534 SSLYETLSQFRTANRLLITGTPLQNNLKELASLVNFLMPGKFYIRDELNFDQPNAEQERDIRDLQ 598

  Fly   752 QQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDAL--RKGKRGSTSTFLN 814
            ::|:|:||||:|||||||||:|.|:|||||::.:|.::||.|||||:.||  ....||..| .||
pombe   599 ERLQPFILRRLKKDVEKSLPSKSERILRVELSDMQTEWYKNILTKNYRALTGHTDGRGQLS-LLN 662

  Fly   815 IVIELKKCCNHAALIRPSEFE--LMG--LQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIF 875
            ||:||||..||..|. |...|  :||  :.:::.|:.::..|||:|||||||.|||..|||||||
pombe   663 IVVELKKVSNHPYLF-PGAAEKWMMGRKMTREDTLRGIIMNSGKMVLLDKLLQRLKHDGHRVLIF 726

  Fly   876 SQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLAT 940
            |||||||::|.:|:..|.:.:|||||:|...:||.::|||||..|.||.||||||||||||||.|
pombe   727 SQMVRMLNILGEYMSLRGYNYQRLDGTIPASVRRVSIDHFNAPDSPDFVFLLSTRAGGLGINLNT 791

  Fly   941 ADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRM 1005
            ||||||||||||||.||||.||||||||||.||:||.::..:|||.|:|||::||:|::.:|
pombe   792 ADTVIIFDSDWNPQADLQAMARAHRIGQKNHVNVYRFLSKDTVEEDILERARRKMILEYAII--- 853

  Fly  1006 DTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFK--DEQEHDDDLVCDIDEILRRAETR 1068
             :.|  |.:||.|   |.::.::..:|||||||||..:||  :.|:..:::  ::|:||..||.|
pombe   854 -SLG--VTEKSKN---SKNDKYDAQELSAILKFGASNMFKATENQKKLENM--NLDDILSHAEDR 910

  Fly  1069 NEDPE-----MPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAI 1128
            :...:     |..::.|..|:|....|           :|.|          |||||||
pombe   911 DSSNDVGGASMGGEEFLKQFEVTDYKA-----------EDLN----------WDDIIPE------ 948

  Fly  1129 DDQERAKEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRK 1193
            ::.||.:|.|.:....|    |.:.|.:|         ::.::...|.|:         ..|..|
pombe   949 EEMERIEEEERMLAAQR----AKEEERER---------REEEERENDEDH---------PSRTYK 991

  Fly  1194 R------GRPTMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEML 1252
            |      .|...:|::.  .:.|:|...|:..||.....|.:.|..:||||......:..|...:
pombe   992 RTTKSITKRQQRREEMV--REKEIRLLYRAMIKFGLVDERFDTIVKEAELQATDPKRIYSLSADM 1054

  Fly  1253 HDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGV-SFNAKKLLACEQELQPLNEIM 1316
            ...|        :|..:....|:|   |.::.|....::..|| :.||:.:....::|..|:...
pombe  1055 VKAC--------DEAVERLGADDT---KNKQPRKAILIEFKGVKNINAETVTLRVKDLTHLHRAY 1108

  Fly  1317 PSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDT 1381
            ..:...:|...:.|:: ...::..|||:||:.||.||.::|.|.|:.:|.||.|.|.|||.|::.
pombe  1109 KGLDPLKQIIGYPIRS-VHSWNCSWGIKEDSMLLAGINKHGFGCWQAIKNDPDLGLHDKIFLDEA 1172

  Fly  1382 RK-------PQAKQLQTRAEYLLKIIKKNVEL------------------TKGGQR--------- 1412
            :.       |.|..|..|.||||.:::::.:|                  ||...|
pombe  1173 KNDKESRYVPSAVHLVRRGEYLLSVVREHPDLFVVKTDQPTKRKYNRKAPTKSSTRQTTLDGSIS 1237

  Fly  1413 -------------------------------------RQRRP--RASRANDAKAASQSASSTIDA 1438
                                                 ||..|  ||.|:|..||||...::....
pombe  1238 NTKKSSRTKKKKEEETNRGDETSPEGTVGEDEVEEEPRQAEPPKRALRSNSGKAASNKRTTRNSM 1302

  Fly  1439 KPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHGDPAKKAKKSKARSKKTSASDNNG-- 1501
            |.|    :|.|..|...:.::::|                    .....||:.:.......||
pombe  1303 KTH----SAMDTLTAVAALDAELD--------------------NMSNEKAKEEVDHVKSENGES 1343

  Fly  1502 -NKPMHFTANNEPRALE-----VLGDLDPSIFNE 1529
             |:|     |.|..:||     .:.|:.|.:.||
pombe  1344 VNEP-----NTEDLSLETEENTTVSDISPLVKNE 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	21/47 (45%)
		Chromo	458..509	CDD:278797	19/50 (38%)
		SNF2_N	548..829	CDD:278600	151/286 (53%)
		DEXDc	564..709	CDD:238005	81/147 (55%)
		Helicase_C	852..967	CDD:278689	84/114 (74%)
		DUF4208	1521..1610	CDD:290618	4/9 (44%)
		DUF3824	1795..>1894	CDD:289625
hrp1	NP_593660.1	CHROMO	209..267	CDD:237991	27/86 (31%)
		Chromo	305..356	CDD:278797	19/51 (37%)
		SNF2_N	393..677	CDD:278600	151/286 (53%)
		DEXDc	409..555	CDD:238005	81/147 (55%)
		Helicase_C	703..818	CDD:278689	84/114 (74%)
		CHDCT2	1132..>1172	CDD:285336	21/39 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	279	1.000	Domainoid score	I300
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	735	1.000	Inparanoid score	I90
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		otm47113
orthoMCL	1	0.900	-	-		OOG6_102222
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R569
SonicParanoid	1	1.000	-	-		X1425
TreeFam	1	0.960	-	-
	12	11.850