Protein Alignment Chd1 and mit1

DIOPT Version :10

• Sequence 1: NP_001245851.1
• Gene: Chd1 / 33505
• FlyBaseID: FBgn0250786
• Length: 1900
• Species: Drosophila melanogaster
• Sequence 2: NP_595385.1
• Gene: mit1 / 2541336
• PomBaseID: SPBP35G2.10
• Length: 1418
• Species: Schizosaccharomyces pombe
• Alignment Length: 1487
• Identity: 399/1487 - (26%)
• Similarity: 607/1487 - (40%)
• Gaps: 400/1487 - (26%)

  Fly    80 DKSLSV---AGFPPTAAAAQADSKTNG---------------------FTDDQEDSSSD---GSS 117
            |.:|||   ||........:.|...||                     .||..|:..:|   .|:
pombe    40 DSTLSVKFLAGVEALIKKDELDKYKNGKACLRVWLKHKSRKRYHGYMTSTDKDEEEKNDYLLKSN 104

  Fly   118 GSDSDSD---------------AEGPSDQRNQSINNANTSSSLPKPEQ-NEEEDNETEAGQQQPA 166
            ||....|               |..||...:::.:::.||||....:: |.:|.||..      .
pombe   105 GSKVLRDSTRTKKFKFGKEFHCALNPSFVSDETASDSATSSSSDTNKKVNRKEHNELS------L 163

  Fly   167 SDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSD 231
            |..|.:::||..     :|..||||.|                 :.|...|||    ......||
pombe   164 SHLSFNDTSDFG-----SSDLSSSEIE-----------------STENDNKAP----YFSLLYSD 202

  Fly   232 ESD----------------ESEDSD------DEVSTAQKR--KPAATTSRSKLAQQQQRRRVKPF 272
            ..|                |...|.      |..|.....  .|..:.::......||...:.|.
pombe   203 GFDFIKFLHVCVCVKCHGREHRSSGKNFVYCDHCSNVYHYDCSPLPSLNKETRNYSQQNGFICPL 267

  Fly   273 SSEDSDDDDASKRCATRRKGAAVSYKEASED-----EATDSEDL-------------------LE 313
            .|::|.|    ..|.|    ..||...:.:|     ...|.|.|                   :|
pombe   268 CSKNSKD----VLCNT----GFVSGVSSGQDLVIPPSLADRESLSILVNYCKSIRFRCFRCRRVE 324

  Fly   314 -FEYDESQAATTAATAEEEEK-----------CETIERILAQRAGKRGCTGNQTTIY---AIEEN 363
             |.|.:|...:...|.....|           |: ||.|:|.|        ...::|   |...|
pombe   325 YFFYLDSNPLSIQRTITHFIKKLVCNECSMHPCD-IEEIIAWR--------TLNSLYPSKATLSN 380

  Fly   364 GFDPHAGFDEKQTPDAE-TEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQA 427
            .|        ..|.|.. ...::.::.||.||:|..|.|.:.|..:.....|..|
pombe   381 NF--------VSTSDLSFWSREYFVRSKGKSYLHCFWCSASWLAGISLAKKKNFD---------- 427

  Fly   428 YWRRYAGPEDIDYFECQLELQHELLK-SYNNVDRI--IAKGSKPDDGTEEYLCK----------- 478
                  |.|:..|     :....::. ||..:|::  :...|..:..|.:|..|
pombe   428 ------GLENASY-----DATKPIIPVSYTIIDKVWDVQYRSGKNARTAKYKTKKHQLKAISEVT 481

  Fly   479 -----WQSLPYAESTWEDAALVL--RKWQRCAEQFNDRESSKCTPSRHCRVIKYRP--------K 528
                 |:.|.|..|.||......  .:|:...:.::|        ...|..|:..|        .
pombe   482 FAFVSWRGLTYYMSNWEPPPKETDRNRWKAWLKGYSD--------LLECLWIEKAPTASINIDLP 538

  Fly   529 FSRIK--NQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIH 591
            |:.::  :||.|:..| ||..||:.|||||...|...:..|||||||||||:|.|.|:..||..|
pombe   539 FTNLEWHSQPSFIKGG-TLMPYQLKGLNWLYLRWYTHHPCILADEMGLGKTVQVISFISVLFYRH 602

  Fly   592 HLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEW-QFESSKRLKFNCILT 655
            ..: |.|.:||.:|:..|:||...|||.:.:...:|..|:|.|::.|.. ..:..|.:..:.::.
pombe   603 KCF-PVLVIVPHATVANWERELKKWAPFLQINVLVGSEKNRSLVRDYRLINQKDPKHVSTHVLVI 666

  Fly   656 TYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWAL 720
            :...|.::...|...||..|:|||..|||||.|.|:..|....::.:||:|||||||:::||:.|
pombe   667 SASNVEREISLLRKFQWKVLIVDEGQRLKNDQSSLFYYLSSVKSDFKLLLTGTPLQNNVRELFNL 731

  Fly   721 LHFIMPDKFDTWENFEVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSL 785
            |.|:.|.|.:..| .|.::...:.:..|.|||.|:|:.|||||.:|..:.|.|||.|:.:.||.:
pombe   732 LQFLNPMKINAAE-LEKRYSIIDTEKVTELHQILKPFFLRRVKSEVLDNFPTKVEVIIPLSMTPV 795

  Fly   786 QKQYYKWILTKNFDALRK-----------GKRGSTSTFLNIVIELKKCCNHAALIRPSEFELMGL 839
            ||..||.||:||...||.           |:|  |::..||:::|:|...|..:..| :.|...|
pombe   796 QKGLYKSILSKNLSLLRNITGYANTSSSGGQR--TTSLNNILMQLRKTLAHPYIYSP-DIEDRNL 857

  Fly   840 QQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIK 904
            ..:.|:::|.:.|.|.::|..|:.:|...|||:|:|||.::.||:|.|:.:.::..:.|.||: .
pombe   858 PYELAMRSLEEASCKFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFEYKNIAYARFDGA-S 921

  Fly   905 GEMRRQ-ALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQ 968
            .||.|| |:|.|||..|:..||||||||||:|||||:||||||.|.|:||..|:||.|||||.||
pombe   922 SEMERQSAIDSFNAPNSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQDMQAIARAHRYGQ 986

  Fly   969 KNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLS 1033
            |.:|.::.|.|..||||:|::.|::|:|||||:::.:|           ..|:|      :.||.
pombe   987 KKKVLVFVLTTRDSVEEKIIQNAQKKLVLDHLIVESLD-----------QNHNS------EKDLE 1034

  Fly  1034 AILKFGAEELFKDEQEHDDDLV----CDIDEILRRAETRNEDPEMPADDLLS----AFKVASIAA 1090
            :||:.||..||  |:..|:..:    ..::.::..|| :.||......|:.|    .|:|..
pombe  1035 SILRHGARALF--EEAGDEPSIKYNEYSVELLISEAE-KQEDTSTDESDIKSNKFGFFRVWD--- 1093

  Fly  1091 FEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPPRRKTAANQNEG 1155
             .:..|.:..:..:|...:|:|.  |..|:          ::|.|   |..|....:|.:|:.
pombe  1094 -NKHISSNHYEVKENVLVDEEDV--WSVIL----------KQREK---DAMLEKTDETTSNRR-- 1140

  Fly  1156 KRGAGKGGKGKQ-QADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYK 1219
            .|...|...|:. ...|:..|:||.:....|  .|.|    .|...|.|:..||.
pombe  1141 LRAHHKIHYGEDLNIYDNSDDTDYTVNDRSS--PGSP----FPIETETISSITDT---------- 1189

  Fly  1220 KFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRA 1284
                             |.:|.        ::.:|..|...:.:.|.:|            |:.|
pombe  1190 -----------------LSDKQ--------KLKYDSSVNIENLNDESDS------------QKSA 1217

  Fly  1285 RATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKL 1349
            ...|.      |..||.|||             :.|:|.:   || ||.:.:
pombe  1218 DVHFD------SILAKSLLA-------------TTPKEDE---FN-KTLSTI------------- 1246

  Fly  1350 LCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKIIKKNVEL 1406
                           .|:...|||....:||:.............|  :||:||.:|
pombe  1247 ---------------NLEVANKLTSSEYINDSEMQLIDDPVFYPPY--EIIEKNHQL 1286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CD1_tandem_CHD1-2_like	339..421	CDD:349313	19/85 (22%)
		CD2_tandem	454..508	CDD:349306	14/73 (19%)
		PLN03142	531..>1066	CDD:215601	217/553 (39%)
		CDH1_2_SANT_HL1	1205..1298	CDD:465731	12/92 (13%)
		DUF4208	1521..1610	CDD:464035
mit1	NP_595385.1	PHD	214..268	CDD:214584	8/53 (15%)
		CD_CSD	359..426	CDD:475127	20/82 (24%)
		PLN03142	546..>1086	CDD:215601	223/566 (39%)
		zf-CCCH_7	1235..1329	CDD:376012	17/86 (20%)
		zf-CCCH_6	1331..1383	CDD:436598