DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and Chd2

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001074814.2	Gene:	Chd2 / 244059	MGIID:	2448567	Length:	1827	Species:	Mus musculus

Alignment Length:	1946	Identity:	881/1946 - (45%)
Similarity:	1162/1946 - (59%)	Gaps:	262/1946 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRNQSIN 137
            :...:.||.||.          :.|.|:          |:|:..|||||.|.:|........|.:
Mouse     5 KDKSQEEDSSLH----------SNASSR----------SASEEVSGSDSGSQSESEQGSEPGSGH 49

  Fly   138 NANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRT 202
            .:.::||....|...|.::|:...:.||....:.::.:.....::..  ....||..:.|..:|:
Mouse    50 GSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKKERIADV--KKMWEEYPDVYGVRRS 112

  Fly   203 RQARKPPT------AAEKSKKAPAPK-------NKKKTWDSDES-DESEDSDDEVSTAQKRK--- 250
            .::|:.|:      .|....::.:||       .|::.|..|.| ||.|......|.|:::|
Mouse   113 NRSRQEPSRFNVKEEASSGSESGSPKRRGQRQLKKQEKWKQDPSEDEQEQGTSAESEAEQKKGKA 177

  Fly   251 ----PAATTSRSKLAQQ---QQRRRVKPFSSEDSDDDDASKRCATRRKGAA-VSYKEASEDEATD 307
                |..|..:.::.:|   |:.:|.|..||:|.||||.:.:..|||:.|. ||||| .:|..||
Mouse   178 RRPVPRRTVPKPQVKKQPKIQRGKRKKQESSDDDDDDDEAPKRQTRRRAAKNVSYKE-DDDFETD 241

  Fly   308 SEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFD 372
            |:||:|.        |.....|:::..||||::|..|.||:|.||..||:||:|.|| ||...||
Mouse   242 SDDLIEM--------TGEGGDEQQDNSETIEKVLDSRLGKKGATGASTTVYAVEANG-DPSDDFD 297

  Fly   373 EKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPED 437
               |...|.|.|:|||||||||||:|||||.:|:..|.||:|||:||.|||.|...|.....|||
Mouse   298 ---TEREEGEVQYLIKWKGWSYIHSTWESEDSLQQQKVKGLKKLENFKKKEDEVKQWLGKVSPED 359

  Fly   438 IDYFECQLELQHELLKSYNNVDRII---------------AKGSKPDDGTE-EYLCKWQSLPYAE 486
            ::||.||.||..||.|.|..|:|:|               |...||....| ||||||..|||:|
Mouse   360 VEYFSCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSE 424

  Fly   487 STWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFL-SSGLTLRDYQM 550
            .:|||.||:.:|:|.|.:.|:.|.:||..|:|.|:.:|.||:|..:|.||.:| ...|.|||||:
Mouse   425 CSWEDEALIGKKFQNCIDSFHSRNNSKTIPTRECKALKQRPRFVALKKQPAYLGGESLELRDYQL 489

  Fly   551 DGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDL 615
            :|||||.|||||.||||||||||||||||||.||..||..|.||||||.||||||:|:|||||::
Mouse   490 EGLNWLAHSWCKSNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTSWQREFEI 554

  Fly   616 WAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEA 680
            |||::|||.|:||:.||..|::|||....:||||||.::|||||:||||..||::.||.|.||||
Mouse   555 WAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEA 619

  Fly   681 HRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDK 745
            ||||||||||||:|.:|.:|||||||||||||||||||:|||||||:||:.||:||..||...:.
Mouse   620 HRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGREN 684

  Fly   746 GYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTS 810
            ||..||:.|||::||||||||||||||||||||||||::|||||||||||:|:.||.||.|||||
Mouse   685 GYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKALAKGTRGSTS 749

  Fly   811 TFLNIVIELKKCCNHAALIR-PSEFELMGLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLI 874
            .|||||:||||||||..||: |.:.|....|  |.||:|::.||||:||||||.||:|.|:||||
Mouse   750 GFLNIVMELKKCCNHCYLIKAPEDSERESGQ--EVLQSLIRSSGKLILLDKLLTRLRERGNRVLI 812

  Fly   875 FSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLA 939
            |||||||||:||:||..:|:||||||||||||:|:||||||||:||:||||||||||||||||||
Mouse   813 FSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLA 877

  Fly   940 TADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQR 1004
            :||||:||||||||||||||||||||||||.|||||||||..:|||:|:||||:|||||||||||
Mouse   878 SADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQR 942

  Fly  1005 MDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKD-EQEHDDDLVCDIDEILRRAETR 1068
            |||||||||:  .|...||||||||::|:||||||||:|||: |.|..:....|||||||.||||
Mouse   943 MDTTGRTVLE--NNSGRSNSNPFNKEELTAILKFGAEDLFKEIEGEESEPQEMDIDEILRLAETR 1005

  Fly  1069 -NEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQE 1132
             ||......|:|||.||||:.|..|:|..           .||...||||:||||..||.::::|
Mouse  1006 ENEVSTSATDELLSQFKVANFATMEDEEE-----------LEERPHKDWDEIIPEEQRKKVEEEE 1059

  Fly  1133 RAKEMEDLYLPPR-----RKTAANQN----EGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDD 1188
            |.||:|::|:.||     :|...|.:    |.||.|.:....:.:.||             |.||
Mouse  1060 RQKELEEIYMLPRIRSSTKKAQTNDSDSDTESKRQAQRSSASESETDD-------------SDDD 1111

  Fly  1189 GRPRKRGRP--TMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEM 1251
            .:|::||||  ..|:.:.||||||:||||::||||..||.|:|.||.||||.:|.:|:||||||:
Mouse  1112 KKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADLKRLGEL 1176

  Fly  1252 LHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIM 1316
            :|:.||..:.|::|:..::.:..:.||  :||..   ::|:.||..|.|.::..|:|.:.|::.:
Mouse  1177 IHNSCVSAMQEYEEQLKESTSEGKGPG--KRRGP---TIKISGVQVNVKSIIQHEEEFEMLHKSI 1236

  Fly  1317 PSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDT 1381
            |..|||::::....:.:|..|||:||:|:|::||.|||::|.|:||.:|.||.||||||||..:|
Mouse  1237 PVDPEEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYGNWELIKTDPELKLTDKILPVET 1301

  Fly  1382 -RKPQAKQLQTRAEYLLKIIKKNVELTKG-------GQRRQRRPRASRANDA-----KAASQSAS 1433
             :|||.||||||.:||||:::|.:| .||       .:.::|:||..:.|.|     :...:.||
Mouse  1302 DKKPQGKQLQTRVDYLLKLLRKGLE-KKGTVASGEEAKLKKRKPRVKKENKAPRLKDEHGLEPAS 1365

  Fly  1434 STIDAKPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPAT---EQHGDPAKKAKKSKARSKKTS 1495
            ......|.:..:...|....:.:...|...........|.:   ::.||  |:.||||.:.:|..
Mouse  1366 PRHSDNPSEEGEVKDDGLEKSPTKKKQKKKENKENKEKPVSSRKDREGD--KERKKSKDKKEKVK 1428

  Fly  1496 ASDNNGNK-------PMHFTANNEPRAL--EVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSL 1551
            ..|...:.       |:|.||.:||..:  :...|||...|:.|||:|||||||||.||:||..|
Mouse  1429 GGDGKSSSKSKRSQGPVHITAGSEPVPIGEDEDDDLDQETFSICKERMRPVKKALKQLDKPDKGL 1493

  Fly  1552 SDQDQLQHTRDCLLQIGKQIDVCLNPYAETEK-KEWRSNLWYFVSKFTELDAKRLFKIYKHALKQ 1615
            |.|:||:|||:|||:||.:|..||..|::.|. |.||.|||.|||||||.||::|.|:||.|.|:
Mouse  1494 SVQEQLEHTRNCLLKIGDRIAECLKAYSDQEHIKLWRRNLWIFVSKFTEFDARKLHKLYKMAHKK 1558

  Fly  1616 KAGGDGEAKGKDKGSSGSPAKSKPNGVTTEEKEKERDRSGGKKKKKDKDKERSGQAR-------- 1672
            ::..:                        ||::|:.|..||||..:   .|.||.:|
Mouse  1559 RSQEE------------------------EEQKKKDDSLGGKKPFR---PEASGSSRDSLISQSH 1596

  Fly  1673 -----YPE-TGIPTS----------GRYADPPLKRKRDENDADAS----------SGLAGAPGGG 1711
                 :|: ..:|.|          ..|:.|   .||..::||..          .|...||.||
Mouse  1597 TSHNLHPQKPHLPASHGPQMHGHPRDNYSHP---NKRHFSNADRGDWQRERKFNYGGGNSAPWGG 1658

  Fly  1712 IGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSG--PPMGSGSYEGGSNSRRQGPTSPSTPRTG 1774
                           |||...::|.....:||...  ....||||...:.||::.....::.|..
Mouse  1659 ---------------DRHHQYEQHWYKDHHYGDRRHMDAHRSGSYRPNNMSRKRPYEQYNSDRDH 1708

  Fly  1775 RGGYDPPPAPSGYTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQGSYHRERDRRPEKRRYPSGL 1839
            ||..|                ..||:..|.||.|.|.:......|..:.|..|.||....:..|.
Mouse  1709 RGHRD----------------YYDRHHHDSKRRRSDDFRPQNYHQQDFRRMSDHRPTMGYHGQGP 1757

  Fly  1840 PPHPYSSHYLPPNYYGLPNGAVPGLPPPSSVYRSDPRGYPVM--PRD--YPADYRRSDYER 1896
            ..|..|.|......|..|   :|.|    ....||||..|..  |.|  .|.|: ||..||
Mouse  1758 SDHYRSFHTDKLGEYKQP---MPSL----HTALSDPRSPPSQKSPHDSKSPLDH-RSPLER 1810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	29/47 (62%)
		Chromo	458..509	CDD:278797	26/66 (39%)
		SNF2_N	548..829	CDD:278600	205/280 (73%)
		DEXDc	564..709	CDD:238005	102/144 (71%)
		Helicase_C	852..967	CDD:278689	97/114 (85%)
		DUF4208	1521..1610	CDD:290618	55/89 (62%)
		DUF3824	1795..>1894	CDD:289625	31/102 (30%)
Chd2	NP_001074814.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..264		75/289 (26%)
		CHROMO	282..344	CDD:237991	39/65 (60%)
		Chromo	379..447	CDD:278797	26/67 (39%)
		SNF2_N	487..768	CDD:278600	205/280 (73%)
		DEXDc	503..648	CDD:238005	102/144 (71%)
		DEAH box	617..620		2/2 (100%)
		Helicase_C	790..905	CDD:278689	97/114 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1124		38/117 (32%)
		DUF5102	<1042..1165	CDD:293709	58/135 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1329..1465		28/137 (20%)
		DUF4208	1471..1553	CDD:290618	51/81 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1556..1638		22/111 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1679..1827		43/156 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I692
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37462
Inparanoid	1	1.050	1473	1.000	Inparanoid score	I108
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54459
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		otm42861
orthoMCL	1	0.900	-	-		OOG6_102222
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R569
SonicParanoid	1	1.000	-	-		X1425
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860