DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and chd-1

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_491994.2	Gene:	chd-1 / 172432	WormBaseID:	WBGene00010369	Length:	1461	Species:	Caenorhabditis elegans

Alignment Length:	1669	Identity:	691/1669 - (41%)
Similarity:	948/1669 - (56%)	Gaps:	262/1669 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SSSDGSSGSDSDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESS 175
            :.|:.|||||::.|.:.....|.:.....|::|        |:.|.:.:|.....:|...:|:|.
Worm     3 NQSESSSGSDAEPDEKTDEPVREEENPEGNSTS--------EDNDEKEKAADSPESSSDQSDDSD 59

  Fly   176 DSSANVSPTSSSSSSEEEEEDYRPKR-----------TRQARKPPTAAEKSKKAPAPKNKKKTWD 229
            |:|.|      |||||.:|.  .||:           ||:..:......:||::    .::....
Worm    60 DASEN------SSSSEPDEP--APKKKNNNNRGMDAETRKLLENENYFRRSKRS----KRQDDSP 112

  Fly   230 SDESDESEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAA 294
            ||.|:||:.|:|:..  .:|||..|.::..:.|.::...|                  .:||...
Worm   113 SDNSEESQSSEDDWD--DRRKPRRTVTKKVVKQTKKAVSV------------------VKRKSVK 157

  Fly   295 --VSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTI 357
              |:|.|.:.|:..|.:|:|  |:||..|......|   ...||:||::..|.|..|.||:.||.
Worm   158 GNVNYAEKNSDDDIDDDDVL--EWDEEPAVPAEGPA---ILTETVERVIKWRHGVPGATGSATTC 217

  Fly   358 YAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKK 422
            |.|.:.| ||:     .|.|..:||.||.:||.|||::|||||||.:|..|.|||:||:.|::||
Worm   218 YNIADKG-DPN-----DQIPGDKTEQQFFVKWTGWSHLHNTWESENSLALMNAKGLKKVQNYVKK 276

  Fly   423 EKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPD---DGT--EEYLCKWQSL 482
            :||...|:|.|..|.|::|||:.::..||.:.|..|:|::|..:..|   ||:  .|||.||..|
Worm   277 QKEVEMWKRSADKEYIEFFECEQQMAEELCEEYKKVERVVAHQTSRDRAADGSMATEYLIKWSGL 341

  Fly   483 PYAESTWEDAALVLRKWQRCAEQ---FNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFL----S 540
            ||::.||||..:|      ..||   :..|..:..:|:::..|::.||||.:.::.|:||    .
Worm   342 PYSDCTWEDEKMV------APEQIKAYYHRIENLKSPNKNSNVLRKRPKFEKFESMPDFLKTDGE 400

  Fly   541 SGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLST 605
            |...|||||::||||::::|||.||.|||||||||||||:|..|.|||..:.|.||:|.||||||
Worm   401 STHKLRDYQLEGLNWMVYAWCKGNSSILADEMGLGKTIQSISLLASLFHRYDLAGPYLVVVPLST 465

  Fly   606 MTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTL 670
            |.|||:||..|||:||:|.|:||:.||::|:||||....:|::|.|.|||||||:||||.||.::
Worm   466 MAAWQKEFAQWAPEMNLVVYMGDVVSRDMIRQYEWFVGGTKKMKINAILTTYEILLKDKAFLSSI 530

  Fly   671 QWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENF 735
            .|||||||||||||||:|||||||.:|..||:||||||||||||||||||||||||:|||.||.|
Worm   531 DWAALLVDEAHRLKNDESLLYKSLTQFRFNHKLLITGTPLQNSLKELWALLHFIMPEKFDCWEEF 595

  Fly   736 EVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDA 800
            |..|..:..||.:.||::|||::|||||||||||||.|.||||||:||:.|||:||||||||:..
Worm   596 ETAHNESNHKGISALHKKLEPFLLRRVKKDVEKSLPPKTEQILRVDMTAHQKQFYKWILTKNYRE 660

  Fly   801 LRKGKRGSTSTFLNIVIELKKCCNHAALIRPSEFELMGLQQDEALQTLLKGSGKLVLLDKLLCRL 865
            |.||.:||.:.|:|:|:|||||||||:|.|  :::.:.......||.|||.||||:|||||||||
Worm   661 LSKGVKGSINGFVNLVMELKKCCNHASLTR--QYDHIYDDAQGRLQQLLKSSGKLILLDKLLCRL 723

  Fly   866 KETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTR 930
            |:.|||||||||||.|||:|.:|||.|.||.||||||::.::|:|||||:||.||.||.||||||
Worm   724 KDKGHRVLIFSQMVMMLDILQEYLQLRRFPSQRLDGSMRADLRKQALDHYNAPGSTDFAFLLSTR 788

  Fly   931 AGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKM 995
            |||||||||||||||||||||||||||||.:|||||||...||||||||..||||:||||||:|:
Worm   789 AGGLGINLATADTVIIFDSDWNPQNDLQAMSRAHRIGQTKTVNIYRLVTKGSVEEEIVERAKRKL 853

  Fly   996 VLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDE 1060
            ||||||||||||||:|||.|  |..:|.|.||:|.:|||||||||.||||:::..:.:...|||.
Worm   854 VLDHLVIQRMDTTGKTVLSK--NATASGSVPFDKQELSAILKFGAVELFKEKEGEEQEPEVDIDR 916

  Fly  1061 ILRRAETRNEDPE-MPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGF 1124
            ||..||||..:.| |..::|||:||.|:.|..||        :|..||.:|     |..||||..
Worm   917 ILMGAETREAEEEVMKENELLSSFKYANFAIDEE--------KDIAAATDE-----WAAIIPEED 968

  Fly  1125 RKAIDDQERAKEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDG 1189
            |..|.::||.||:.::.|.||::....              .|..:|..||.|.|     ..|.|
Worm   969 RNRILEEERMKELAEMNLAPRQRKQPI--------------PQVVEDDDGDDDEE-----EDDTG 1014

  Fly  1190 RPRKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHD 1254
            :.:|      |:.:..||..|::|||:|::||..||:|:|.||.||||:|....|:|:|.|.|.:
Worm  1015 KKKK------KKAVGNFTIPEIKRFIKSFRKFSMPLNRLEEIAQDAELEEHSTDEMKKLVESLSE 1073

  Fly  1255 RCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSM 1319
            .|.:...|....|.    ..:...|:..:.......|......|.|::.....||:||:||:.|
Worm  1074 ACKKAADEFDSNEK----NGDAGAAESEKKDIERKFKFHTCDVNLKQIERSHAELKPLHEILKS- 1133

  Fly  1320 PEERQQWSFNIKTRAPV---FDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLND- 1380
              |..:.||.....|.:   :||||...:|:.||.|:::||.||||.:|:||||.|.|||.:.|
Worm  1134 --EETKTSFKPPANAKLQKGWDVDWSRPDDSALLLGVWKYGYGSWEAIKMDPTLGLADKIFIKDK 1196

  Fly  1381 TRKPQAKQLQTRAEYLLKIIKKN-VELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGE 1444
            |:|||.|.||.|.:||||::.|: |:.|      :::.|..:|:|.....:......:..|.:||
Worm  1197 TKKPQGKNLQVRVDYLLKLMSKDKVKTT------EKKERKRKADDVPVGPEKKKRHTNNVPQEGE 1255

  Fly  1445 DAAGDARTVAESSNSQVDPSTASPHNAPATEQHGDPAKKAKKSKARSKKTSASDN----NGNKPM 1505
                                                 ||.|:.|.....:|..|.    :.:|.:
Worm  1256 -------------------------------------KKKKEKKEEKNSSSLKDQLALLSIDKSL 1283

  Fly  1506 HFTANNEPRALEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIG-- 1568
            :..|         |.|.....|.||.:...||.|.:|.|.:...:.:..|:.::    |.::|
Worm  1284 YGGA---------LEDSSAKPFLECVKLCMPVHKYMKKLKEAQEAKNQADEAKY----LTRLGDS 1335

  Fly  1569 --KQIDVCLNPYAETEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGKDKGSS 1631
              :.::..:....:|..::|.:.||.|:.|||..:...:...|:.....|         ......
Worm  1336 FLENLETLIKKKPKTNIRKWYNYLWIFLCKFTLREPGEMADRYRSITSDK---------HKNHHH 1391

  Fly  1632 GSPAKSKPNGVTTEEKEKE-RDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDE 1695
            ....|||      |||.|| :|.     |::|::|:|                      :|.|.|
Worm  1392 HHHHKSK------EEKPKEAKDH-----KERDREKDR----------------------ERNRGE 1423

  Fly  1696 NDADASSGLAGAPGGGIGDNLKSMSFKRLNMDRHEDRKK--HHR 1737
            ...|...|.:                |..:.:.|:|..|  |||
Worm  1424 RRMDHGEGTS----------------KDHHREHHKDHHKDHHHR 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	26/47 (55%)
		Chromo	458..509	CDD:278797	21/58 (36%)
		SNF2_N	548..829	CDD:278600	191/280 (68%)
		DEXDc	564..709	CDD:238005	98/144 (68%)
		Helicase_C	852..967	CDD:278689	92/114 (81%)
		DUF4208	1521..1610	CDD:290618	20/92 (22%)
		DUF3824	1795..>1894	CDD:289625
chd-1	NP_491994.2	CHROMO	<232..276	CDD:237991	24/43 (56%)
		Chromo	312..362	CDD:278797	21/55 (38%)
		SNF2_N	408..688	CDD:278600	191/279 (68%)
		DEXDc	427..569	CDD:238005	96/141 (68%)
		Helicase_C	710..825	CDD:278689	92/114 (81%)
		DUF4208	1289..1379	CDD:290618	20/93 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167995
Domainoid	1	1.000	385	1.000	Domainoid score	I426
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37462
Inparanoid	1	1.050	1121	1.000	Inparanoid score	I115
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54459
OrthoDB	1	1.010	-	-		D57339at2759
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		oto18494
orthoMCL	1	0.900	-	-		OOG6_102222
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R569
SonicParanoid	1	1.000	-	-		X1425
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800