DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and chd-7

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_491426.2	Gene:	chd-7 / 172079	WormBaseID:	WBGene00007053	Length:	2967	Species:	Caenorhabditis elegans

Alignment Length:	2134	Identity:	559/2134 - (26%)
Similarity:	873/2134 - (40%)	Gaps:	564/2134 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YHLKPDKSKQFDPGCRALNESANSIGSDEQDDTREEANGTDHSGSGSGSGSSGSDSDSDSSSGN- 68
            :..:|::.:|..|       |...||......:.|.:...|.|...|.:....:.:.|.||...
Worm   561 HQTQPNQQQQQHP-------SGYGIGVSTAPASMEPSQSVDQSAPPSQAQIPATSTPSTSSQQQN 618

  Fly    69 ---------SSDGRSSP--EPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQE------------- 109
                     ||.|...|  .||.........|....::|.|.:....:|.||
Worm   619 AYPEFPDFPSSSGYQEPTVAPEAIPSPSVSDPIMPQSSQNDQELQAISDQQEILEDVPKEEPIIE 683

  Fly   110 ------DSSSDGSSGSDSDSDAEGPSDQRNQS--------INN---------ANTSSSLP--KPE 149
                  :.|.:.....:...:.|...||::.|        |:|         |..|:..|  :.|
Worm   684 EDEPKYEYSQETIPVEELKDEVEFKEDQQSTSNLLEDDTGIDNFVKNEEGAEAGYSNGTPLDQVE 748

  Fly   150 QNEEEDNETEAGQ----QQPASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPT 210
            ||:.|:.|.|..|    .:|....:..|.:|:.....|:..:.....||....|....:.....:
Worm   749 QNDYENIEKEEPQVSVDPEPVEVEAQQEPADTEEYPIPSVGTIEEPAEEPAEEPVEEPEPMDDSS 813

  Fly   211 AAEKSK--KAPAPKN---KKKTWDSDESDESEDSDDEVSTAQKRK-------------------- 250
            ..::|.  ||...:|   .::|:..:|..:.|| |||.|:|:..|
Worm   814 PVDQSTPVKADDIENFAGVEETFGEEEEVQDED-DDEASSAKSSKDDIKEEEDDDTSTITKDMSE 877

  Fly   251 --------------PA-----ATTSRSK--------LAQQQQRRRVKPFSSEDSDDDD-ASKRCA 287
                          ||     ||:|:.|        :|:.::::.|     :|||||| ..:|..
Worm   878 APSETNDGFTEPSTPATPLMGATSSKKKSYRRPAVVVAKSRKKKSV-----DDSDDDDFYPQRGR 937

  Fly   288 TRRKGAAVSYKEASEDEA------TDSED---LLEFEYDESQAATTAATAEEEEKCETIERILAQ 343
            .::||.....|....|||      :|.||   |::.:           |...:.....:|:||..
Worm   938 GKKKGGGGKKKADPTDEAGVEGAKSDDEDDEFLMKID-----------TPAPDPNAMVVEKILNM 991

  Fly   344 RAGK-----------RGC--TGNQTTIYAIE-------ENGFDPHAGFDEKQTPDAETE------ 382
            |.||           .|.  .|.:.:...::       |||.....|...|...::||.
Worm   992 RMGKVEKKVPETEVAEGSEENGEEKSEEKVKKEPKENGENGESVGNGESSKSKTESETNEIEEEE 1056

  Fly   383 -AQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLE 446
             .||||||||.||:|..|::.|.|.::..:...|:..| |.:|..:|      .||.:.|.....
Worm  1057 VEQFLIKWKGRSYVHCEWKTAAELLEIDKRVEAKIKRF-KVKKMSSY------IEDDEDFNSDFV 1114

  Fly   447 LQHELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPYAESTWEDAALV----LRKWQRCAEQFN 507
            :          |||::...:: |||.|..|.||:||.|.|.|||...::    :..|
Worm  1115 I----------VDRVVDLITE-DDGQEFVLIKWKSLGYEEVTWEPIEMIPADKVELW-------- 1160

  Fly   508 DRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEM 572
             ||.....|::.....:..|:..:..:..:...:|.:||:||.:|::|||:.:....:.||||||
Worm  1161 -RERQVIDPAKIREKQRPEPEEWKKMSTSKVWKNGNSLREYQFEGVDWLLYCYYNAQNCILADEM 1224

  Fly   573 GLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQ 637
            |||||:|||.||..::. :.::||||.||||||:..|.|||:.|. |||.:.|.|...:||::||
Worm  1225 GLGKTVQTITFLSRIYD-YGIHGPFLVVVPLSTIQNWVREFETWT-DMNAIVYHGSAYAREVLQQ 1287

  Fly   638 YEWQFESSKR-----------LKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDD-SLL 690
            ||..::  ||           :|.:.::||:|.|:.|.:||..:.|...::||||||||.: .||
Worm  1288 YEVFYD--KRHCGAKNWKKNFVKIDALITTFETVVSDVEFLKKIPWRVCVIDEAHRLKNRNCKLL 1350

  Fly   691 YKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQL 754
            ...|..|...||:|:|||||||::.||::||:|:.|.:||....|..|.|:.: |....:|.:.|
Worm  1351 VNGLLAFRMEHRVLLTGTPLQNNIDELFSLLNFLHPQQFDNSATFLEQFGSCQTDDQVQKLQEIL 1415

  Fly   755 EPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLNIVIEL 819
            :|.:|||:|:||||||..|.|.|:.|:::.:||::|:.||.:||..|.||.  |..:.:|:::||
Worm  1416 KPMMLRRLKEDVEKSLGPKEETIIEVQLSDMQKKFYRAILERNFSHLCKGT--SAPSLMNVMMEL 1478

  Fly   820 KKCCNHAALIRPSE------FELMGLQQDE---ALQTLLKGSGKLVLLDKLLCRLKETGHRVLIF 875
            :|||||..||..:|      |.|.....||   |.:.|::.|||:||::|||.:|::.||:||||
Worm  1479 RKCCNHPFLINGAEEAIMNDFRLAHPDWDEETLAHKALIQASGKVVLIEKLLPKLRKDGHKVLIF 1543

  Fly   876 SQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLAT 940
            ||||::||:|.::|....:||:|:||:::|::|:.|:|.|:.|.|..|.|||.||||||||||..
Worm  1544 SQMVKVLDLLEEFLISMSYPFERIDGNVRGDLRQAAIDRFSKENSDRFVFLLCTRAGGLGINLTA 1608

  Fly   941 ADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRM 1005
            ||||||||||||||||||||||.||||||..|.:|||:|:.:.|.::.::|..|:.||..|:|
Worm  1609 ADTVIIFDSDWNPQNDLQAQARCHRIGQKKLVKVYRLITSNTYEREMFDKASLKLGLDKAVLQ-- 1671

  Fly  1006 DTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDL-VCDIDEILRRAETRN 1069
               ..|.|...|..       .:|.|:..:||.||.....||:...... ..||:.||:|   |.
Worm  1672 ---STTALKAEGTA-------LSKKDVEELLKKGAYGSIMDEENESSKFNEEDIETILQR---RT 1723

  Fly  1070 EDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGF----RKAIDD 1130
            :...:.|....|.|..|:.                |::..:.|..|.||  ||.:    .||..|
Worm  1724 QTITLEAGQKGSLFAKATF----------------NSSHNKGDDIDIDD--PEFWTKWAEKAQVD 1770

  Fly  1131 QERAKEMED----LYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRP 1191
            .|:|....|    :...||::|.              :.::..|:  ||||   ||:.||:
Worm  1771 VEKATATPDGRELIIEEPRKRTK--------------RFEENKDE--GDSD---GSEESGN---- 1812

  Fly  1192 RKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQE---KPLAELKRLGE--- 1250
            ||||....:::..|  :.|...:..||:.......:.|....:..|.:   ...||:|:.||
Worm  1813 RKRGAAEKRKRRRG--NDEDGDYSGSYRPDELATSKAEYFKVEKVLAQYGWGRWAEIKKYGELEI 1875

  Fly  1251 ------------MLH--------DRCVQFLH-----EHKEEESKTAATDETPGAKQRRARATFSV 1290
                        :||        ||..||:.     :..:|..|..|     |:...:..|
Worm  1876 SEQDIEHMSRTLLLHCIREFRGDDRIRQFVFNLIRPQGIQENQKLGA-----GSMYNQGWA---- 1931

  Fly  1291 KLGGVSFN-----------------AKKLLACEQELQPLNEIMPSMPEERQQWSFNIK------- 1331
              |...||                 |.||:.....|:.| ||.....|......||:|
Worm  1932 --GLPEFNPPSFALDSAFQRHVHRHANKLMVKIDMLKHL-EIHLIGDERALVEDFNVKWTDIKLP 1993

  Fly  1332 ---TRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKIL---------------- 1377
               |.:..|...|..:.|...|.|.:::|:.:::.:::|..|...:|.|
Worm  1994 EMPTISETFIEGWDSDCDKCFLIGCWRHGLDNFDAIRVDENLCFAEKNLAVWPGQTDFWLRFRRL 2058

  Fly  1378 ---------------LNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQR-----RQRRPRASRA 1422
                           ||.|::.:.:.::....|.:|     ..:.:||..     :...|...:.
Worm  2059 LTSSQKSVHDPVYNKLNWTKREEQEFIRVVRSYGVK-----TNIGEGGNEDWTIFKTLSPILEKK 2118

  Fly  1423 ND---------AKAASQSASSTIDAKPHDGEDAAGDARTVAESSNSQVDP--------------- 1463
            .|         ..|..|.|..:.|.||.|.:.|            ..:||
Worm  2119 TDEDCHEQLMCVLAMCQRAQGSNDLKPIDLKRA------------MSIDPMPTRKAIKMMNRISL 2171

  Fly  1464 --------STASPHNAPATEQHGDPA-------KKAKKSKARSKKTSASDNNGNKPMHFTANNEP 1513
                    .|.|..|....|..|.|:       |:..:...:......:.|..|||. ||....|
Worm  2172 MRKVHTMVQTLSELNLELCETTGMPSGWCMQHDKELMEICDQCGLDQLAANVLNKPA-FTKIVRP 2235

  Fly  1514 -------RALEVL---------GDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRD 1562
                   |.||::         |..|....|:...:.:....|:.|.....:.|..|.|.|.
Worm  2236 SETTLLRRLLEIVATIESGKWCGVADVETVNDSDSEDKKDMAAVAAAQAQFLRLQQQQQQQQ--- 2297

  Fly  1563 CLLQIGKQIDVCLNPYAETEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQK---AGGDGEAK 1624
                  :...|..:..|..:....|.|        .:.|||      ..|::|.   .||.|.|:
Worm  2298 ------QAAAVAASSSASRKASRKRPN--------NDNDAK------MRAMQQMLMGQGGSGAAE 2342

  Fly  1625 --------------GKDKGSSGSPAKSKP-NGVTT------EEKEKERDRSGGKKKKKDKDKERS 1668
                          ....|.:.:.|:.:. |.:.|      .:::::...|..|.....:...::
Worm  2343 YASMIALMLMPQMMAASGGQNMTAAQQQALNQMLTMLIAGAVQQQQQAQPSTSKGASSSQSSAQA 2407

  Fly  1669 GQARYPETGIPTSGRYADPPLKRKRDENDADASSGLAGAPGGGIGDN---LKSMSFKRLNMDRHE 1730
            .||...:.......:.|            |.||:..:.|....:...   |:::....:|
Worm  2408 NQAAQAQAAAVALAQVA------------AAASASTSSADAQAVAQQQQVLEALLAMSMN----- 2455

  Fly  1731 DRKKHHRGPDYYGGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAP 1784
                             |....:..|.|:|  .|.::||.|:..:      |||
Worm  2456 -----------------PAALAALTGTSSS--TGTSTPSAPKKSK------PAP 2484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	19/54 (35%)
		Chromo	458..509	CDD:278797	18/54 (33%)
		SNF2_N	548..829	CDD:278600	129/293 (44%)
		DEXDc	564..709	CDD:238005	70/156 (45%)
		Helicase_C	852..967	CDD:278689	73/114 (64%)
		DUF4208	1521..1610	CDD:290618	15/88 (17%)
		DUF3824	1795..>1894	CDD:289625
chd-7	NP_491426.2	CHROMO	<1059..1095	CDD:214605	16/36 (44%)
		Chromo	1115..1163	CDD:278797	19/67 (28%)
		SNF2_N	1200..1488	CDD:278600	129/293 (44%)
		DEXDc	1216..1369	CDD:238005	70/156 (45%)
		Helicase_C	1520..1635	CDD:278689	73/114 (64%)
		SANT	2073..2133	CDD:197842	9/64 (14%)
		SANT	2075..2126	CDD:238096	8/55 (15%)
		BRK	2672..2716	CDD:197800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57339at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820