DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Chd1 and CHD2

DIOPT Version :9

Sequence 1:NP_001245851.1 Gene:Chd1 / 33505 FlyBaseID:FBgn0250786 Length:1900 Species:Drosophila melanogaster
Sequence 2:NP_001262.3 Gene:CHD2 / 1106 HGNCID:1917 Length:1828 Species:Homo sapiens


Alignment Length:1985 Identity:892/1985 - (44%)
Similarity:1169/1985 - (58%) Gaps:303/1985 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 EQDDTREEANGTDHSGSGSGSGS-SGSDSD----SDSSSGNSSDGRSSPEPEDKSLSVAGFPPTA 92
            :::|:...:|.:.||.|...||| |||.|:    ||..||:.|:..||.|               
Human     9 QEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSE--------------- 58

  Fly    93 AAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNE 157
                                   ||.|.|:|::|           :|.:.|....||..|:..::
Human    59 -----------------------SSESQSESESE-----------SAGSKSQPVLPEAKEKPASK 89

  Fly   158 TE-------AGQQQP------ASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKR--TRQARK 207
            .|       ..::.|      .|:.|..|  .|..|:...:||.|     |...|||  .||.:|
Human    90 KERIADVKKMWEEYPDVYGVRRSNRSRQE--PSRFNIKEEASSGS-----ESGSPKRRGQRQLKK 147

  Fly   208 PPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKPA--ATTSRSKLAQQQQ----R 266
                .||.|:.|:.       |..|...|.:|:.|....:.|:|.  .|..:.::.:|.:    :
Human   148 ----QEKWKQEPSE-------DEQEQGTSAESEPEQKKVKARRPVPRRTVPKPRVKKQPKTQRGK 201

  Fly   267 RRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEE 331
            |:.:..|.||.|||:|.||...||....||||| .:|..|||:||:|.        |.....|::
Human   202 RKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKE-DDDFETDSDDLIEM--------TGEGVDEQQ 257

  Fly   332 EKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIH 396
            :..||||::|..|.||:|.||..||:||||.|| ||...||   |...|.|.|:|||||||||||
Human   258 DNSETIEKVLDSRLGKKGATGASTTVYAIEANG-DPSGDFD---TEKDEGEIQYLIKWKGWSYIH 318

  Fly   397 NTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRI 461
            :|||||.:|:..|.||:|||:||.|||.|...|.....|||::||.||.||..||.|.|..|:|:
Human   319 STWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDVEYFNCQQELASELNKQYQIVERV 383

  Fly   462 I---------------AKGSKPDDGTE-EYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRE 510
            |               |...||....| ||||||..|||:|.:|||.||:.:|:|.|.:.|:.|.
Human   384 IAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRN 448

  Fly   511 SSKCTPSRHCRVIKYRPKFSRIKNQPEFL-SSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGL 574
            :||..|:|.|:.:|.||:|..:|.||.:| ...|.|||||::|||||.|||||.|||||||||||
Human   449 NSKTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGL 513

  Fly   575 GKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYE 639
            |||||||.||..||..|.||||||.||||||:|:|||||::|||::|||.|:||:.||..|::||
Human   514 GKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYE 578

  Fly   640 WQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLL 704
            |....:||||||.::|||||:||||..||::.||.|.||||||||||||||||:|.:|.:|||||
Human   579 WIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 643

  Fly   705 ITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKS 769
            ||||||||||||||:|||||||:||:.||:||..||...:.||..||:.|||::|||||||||||
Human   644 ITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKS 708

  Fly   770 LPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAALIRPSEF 834
            |||||||||||||::|||||||||||:|:.||.||.|||||.|||||:||||||||..||:|.| 
Human   709 LPAKVEQILRVEMSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPE- 772

  Fly   835 ELMGLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRL 899
            |.......|.|.:|::.||||:||||||.||:|.|:|||||||||||||:||:||..:|:|||||
Human   773 ENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYPFQRL 837

  Fly   900 DGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAH 964
            |||||||:|:||||||||:||:||||||||||||||||||:||||:|||||||||||||||||||
Human   838 DGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAH 902

  Fly   965 RIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNK 1029
            |||||.|||||||||..:|||:|:||||:||||||||||||||||||:|:  .|...||||||||
Human   903 RIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILE--NNSGRSNSNPFNK 965

  Fly  1030 DDLSAILKFGAEELFKD-EQEHDDDLVCDIDEILRRAETR-NEDPEMPADDLLSAFKVASIAAFE 1092
            ::|:||||||||:|||: |.|..:....|||||||.|||| ||......|:|||.||||:.|..|
Human   966 EELTAILKFGAEDLFKELEGEESEPQEMDIDEILRLAETRENEVSTSATDELLSQFKVANFATME 1030

  Fly  1093 EEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPPR-----RKTAANQ 1152
            :|..           .||...||||:||||..||.::::||.||:|::|:.||     :|...|.
Human  1031 DEEE-----------LEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTND 1084

  Fly  1153 N----EGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRP--TMKEKITGFTDAEL 1211
            :    |.||.|.:....:.:.:|             |.||.:|::||||  ..|:.:.||||||:
Human  1085 SDSDTESKRQAQRSSASESETED-------------SDDDKKPKRRGRPRSVRKDLVEGFTDAEI 1136

  Fly  1212 RRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDET 1276
            ||||::||||..||.|:|.||.||||.:|.:|:||||||::|:.||..:.|::|:..:.|:..:.
Human  1137 RRFIKAYKKFGLPLERLECIARDAELVDKSVADLKRLGELIHNSCVSAMQEYEEQLKENASEGKG 1201

  Fly  1277 PGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVDW 1341
            ||  :||..   ::|:.||..|.|.::..|:|.:.|::.:|..|||::::....:.:|..|||:|
Human  1202 PG--KRRGP---TIKISGVQVNVKSIIQHEEEFEMLHKSIPVDPEEKKKYCLTCRVKAAHFDVEW 1261

  Fly  1342 GIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDT-RKPQAKQLQTRAEYLLKIIKKNVE 1405
            |:|:|::||.|||::|.|:||.:|.||.||||||||..:| :|||.|||||||:||||:::|.:|
Human  1262 GVEDDSRLLLGIYEHGYGNWELIKTDPELKLTDKILPVETDKKPQGKQLQTRADYLLKLLRKGLE 1326

  Fly  1406 ---LTKGGQR---RQRRPRASRANDAKAASQSASSTIDAKPH------DGE--DAAGDARTVAES 1456
               ...||:.   ::|:||..:.|......:.....:.:..|      :||  |...:...:.:.
Human  1327 KKGAVTGGEEAKLKKRKPRVKKENKVPRLKEEHGIELSSPRHSDNPSEEGEVKDDGLEKSPMKKK 1391

  Fly  1457 SNSQVDPSTASPHNAPATEQHGDPAKKAKKSKARSKKTSASDNNGNK-------PMHFTANNEPR 1514
            ...:.:........:...::.||  |:.||||.:.:|..:.|...:.       |:|.||.:||.
Human  1392 QKKKENKENKEKQMSSRKDKEGD--KERKKSKDKKEKPKSGDAKSSSKSKRSQGPVHITAGSEPV 1454

  Fly  1515 AL--EVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNP 1577
            .:  :...|||...|:.|||:|||||||||.||:||..|:.|:||:|||:|||:||.:|..||..
Human  1455 PIGEDEDDDLDQETFSICKERMRPVKKALKQLDKPDKGLNVQEQLEHTRNCLLKIGDRIAECLKA 1519

  Fly  1578 YAETEK-KEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGKDKGSSGSPAKSKPNG 1641
            |::.|. |.||.|||.|||||||.||::|.|:||.|.|:::..:                     
Human  1520 YSDQEHIKLWRRNLWIFVSKFTEFDARKLHKLYKMAHKKRSQEE--------------------- 1563

  Fly  1642 VTTEEKEKERDRSGGKKKKKDKDKERSGQAR-------------YPE-TGIPTS----------G 1682
               ||::|:.|.:||||..:   .|.||.:|             :|: ..:|.|          .
Human  1564 ---EEQKKKDDVTGGKKPFR---PEASGSSRDSLISQSHTSHNLHPQKPHLPASHGPQMHGHPRD 1622

  Fly  1683 RYADPPLKRKRDENDADASSGLAGAPGGGIGDNLKSMSFK--------RLNMDRHEDRKKHHRGP 1739
            .|..|   .||..::||.            ||..:...|.        ....|||...::|....
Human  1623 NYNHP---NKRHFSNADR------------GDWQRERKFNYGGGNNNPPWGSDRHHQYEQHWYKD 1672

  Fly  1740 DYYGGSG--PPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAPSGYTPEMERWQSRDRYSQ 1802
            .:||...  ....||||...:.||::.....|:.|..||..|                ..||:..
Human  1673 HHYGDRRHMDAHRSGSYRPNNMSRKRPYDQYSSDRDHRGHRD----------------YYDRHHH 1721

  Fly  1803 DYKRDRYDGYGRSGGGQGSYHRERDRRPEKRRYPSGLPPHPYSSHYLPPNYYGLPNGAVPGLPP- 1866
            |.||.|.|.:......|..:.|..|.||....:..|...|..|.|......|..|      ||| 
Human  1722 DSKRRRSDEFRPQNYHQQDFRRMSDHRPAMGYHGQGPSDHYRSFHTDKLGEYKQP------LPPL 1780

  Fly  1867 -PSSVYRSDPRGYPVM--PRD--YPADYRRSDYER 1896
             |:.   ||||..|..  |.|  .|.|: ||..||
Human  1781 HPAV---SDPRSPPSQKSPHDSKSPLDH-RSPLER 1811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Chd1NP_001245851.1 CHROMO 374..422 CDD:237991 29/47 (62%)
Chromo 458..509 CDD:278797 26/66 (39%)
SNF2_N 548..829 CDD:278600 205/280 (73%)
DEXDc 564..709 CDD:238005 102/144 (71%)
Helicase_C 852..967 CDD:278689 97/114 (85%)
DUF4208 1521..1610 CDD:290618 54/89 (61%)
DUF3824 1795..>1894 CDD:289625 33/104 (32%)
CHD2NP_001262.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..243 81/301 (27%)
CHROMO 282..344 CDD:237991 40/65 (62%)
Chromo 379..447 CDD:278797 26/67 (39%)
SNF2_N 487..768 CDD:278600 205/280 (73%)
DEXDc 503..648 CDD:238005 102/144 (71%)
DEAH box 617..620 2/2 (100%)
Helicase_C 790..905 CDD:278689 97/114 (85%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1124 37/117 (32%)
DUF5102 <1042..1165 CDD:293709 57/135 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1331..1462 25/132 (19%)
DUF4208 1471..1553 CDD:290618 50/81 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1638 22/123 (18%)
DUF1777 1661..>1749 CDD:285811 26/103 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1680..1828 46/158 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 410 1.000 Domainoid score I687
eggNOG 1 0.900 - - E2759_KOG0384
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37462
Inparanoid 1 1.050 1486 1.000 Inparanoid score I105
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54459
OrthoDB 1 1.010 - - D57339at2759
OrthoFinder 1 1.000 - - FOG0002141
OrthoInspector 1 1.000 - - otm40787
orthoMCL 1 0.900 - - OOG6_102222
Panther 1 1.100 - - O PTHR45623
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R569
SonicParanoid 1 1.000 - - X1425
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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