DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd1 and CHD1

DIOPT Version :9

Sequence 1:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001351042.1	Gene:	CHD1 / 1105	HGNCID:	1915	Length:	1798	Species:	Homo sapiens

Alignment Length:	1919	Identity:	872/1919 - (45%)
Similarity:	1149/1919 - (59%)	Gaps:	282/1919 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NSIG-SDEQDDTREEANGTDHSGSGSGSGSS---------GSDSDSDSSSGNSSDGRSSPEPEDK 81
            ||.| |.:.||....|:|   |||||.||||         .|||||.|.||:.|:..|....|:|
Human    12 NSSGESSQSDDDSGSASG---SGSGSSSGSSSDGSSSQSGSSDSDSGSESGSQSESESDTSRENK 73

  Fly    82 SLSVAGFPPTAAAAQ--------------ADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQR 132
               |...||....|:              |..|.......|:...:..:|||:.||.:...||.
Human    74 ---VQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNSGSEEDSSSSEDSDD- 134

  Fly   133 NQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDY 197
                     |||..|.:::::||.:. :|...|:...|..||.:.       ...||.:|.|.||
Human   135 ---------SSSEVKRKKHKDEDWQM-SGSGSPSQSGSDSESEEE-------REKSSCDETESDY 182

  Fly   198 RPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKPAATTSRSKLAQ 262
            .||...::|||...: |||.......:||.    :.|.||:.|||
Human   183 EPKNKVKSRKPQNRS-KSKNGKKILGQKKR----QIDSSEEDDDE-------------------- 222

  Fly   263 QQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDSEDLLEFEYDESQAATTAAT 327
                        ||.|:|   ||.:.|:....||||| .|:..|||:||||...::       ..
Human   223 ------------EDYDND---KRSSRRQATVNVSYKE-DEEMKTDSDDLLEVCGED-------VP 264

  Fly   328 AEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGW 392
            ..|||:.|||||.:..|.|::|.||..|||||:|.:| ||:|||::.:.|.   |.|:|||||||
Human   265 QPEEEEFETIERFMDCRIGRKGATGATTTIYAVEADG-DPNAGFEKNKEPG---EIQYLIKWKGW 325

  Fly   393 SYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNN 457
            |:||||||:|.||:....:|||||||:.||::|...|.:.|.|||::|:.||.||..:|.|.|..
Human   326 SHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQI 390

  Fly   458 VDRIIA-KGSKPDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCR 521
            |:|||| ...|...|..:|.||||.|||:|.:|||.||:.:|:|.|.:::..|..||.||.:.|:
Human   391 VERIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCK 455

  Fly   522 VIKYRPKFSRIKNQPEFLS--SGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFL 584
            |:|.||:|..:|.||.::.  .||.|||||::|||||.|||||.||.|||||||||||||||.||
Human   456 VLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFL 520

  Fly   585 YSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLK 649
            ..||..|.||||||.||||||:|:||||...||..||.|.|||||.||.:|:.:||....:||||
Human   521 NYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLK 585

  Fly   650 FNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSL 714
            ||.:||||||:||||.|||.|.||.:.||||||||||||||||:|.:|.:|||||||||||||||
Human   586 FNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSL 650

  Fly   715 KELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILR 779
            ||||:|||||||:||.:||:||.:||...:.||..||::|||::|||||||||||||||||||||
Human   651 KELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILR 715

  Fly   780 VEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAALIRP---SEFELMGLQQ 841
            :||::|||||||||||:|:.||.||.:||||.||||::||||||||..||:|   :||    ..:
Human   716 MEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEF----YNK 776

  Fly   842 DEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGE 906
            .||||.|::.||||:||||||.||:|.|:|||||||||||||:||:||:.|.|||||||||||||
Human   777 QEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGE 841

  Fly   907 MRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQ 971
            :|:|||||||||||:||||||||||||||||||:||||:||||||||||||||||||||||||.|
Human   842 LRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQ 906

  Fly   972 VNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAIL 1036
            ||||||||..||||.|:||||:||||||||||||||||:||| .:|:..|| |.||||::|||||
Human   907 VNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVL-HTGSAPSS-STPFNKEELSAIL 969

  Fly  1037 KFGAEELFKD-EQEHDDDLVCDIDEILRRAETRNEDPE--MPADDLLSAFKVASIAAFEEEPSDS 1098
            |||||||||: |.|..:....||||||:||||...:|.  ...|:|||.||||:.:..:|   |.
Human   970 KFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDE---DD 1031

  Fly  1099 VSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPPRRKTAANQNEGKRGAGKGG 1163
            :..:      .|.:||:|::||||..|:.::::||.||:|::|:.||.:..|.|.......|:..
Human  1032 IELE------PERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGRRS 1090

  Fly  1164 KGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTM--KEKITGFTDAELRRFIRSYKKFPAPLH 1226
            :.::.   ||.|||..  |:|.    ||:|||||..  :|.|.||:|||:||||:|||||..||.
Human  1091 RSRRY---SGSDSDSI--SEGK----RPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLE 1146

  Fly  1227 RMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVK 1291
            |::|||.||||.:|...:|:||||::|:.|::.|      :..::.|:.|.|...:....||  :
Human  1147 RLDAIARDAELVDKSETDLRRLGELVHNGCIKAL------KDSSSGTERTGGRLGKVKGPTF--R 1203

  Fly  1292 LGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQY 1356
            :.||..|||.:::.|:||.||::.:||.||||:|::....|:|..||:|||.|:|:.||.|||:|
Human  1204 ISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEY 1268

  Fly  1357 GIGSWEQMKLDPTLKLTDKILLND-TRKPQAKQLQTRAEYLLKIIKKNV----ELTKGGQRRQRR 1416
            |.||||.:|:||.|.||.|||.:| .:|||||||||||:||:|::.:::    .|:..|..::|:
Human  1269 GYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAGSSKRRK 1333

  Fly  1417 PRASRANDAKAAS-----QSASSTIDAKPHDGEDAAGDARTVAESSNSQVD---PSTASPHNAPA 1473
            .||.:....|:..     :|.||.:.::..|.:|...:..:| :..|.::.   .|...|.....
Human  1334 ARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKDEISSV-KHPNKKIKTERDSEEKPEPDVY 1397

  Fly  1474 TEQHGDPAKKAKK---------------------------------------------------- 1486
            .::..:..::||:
Human  1398 IKKEPEEKREAKEKENKKELKREIKEKEDKKDIKEKDFKEKRENKVKEAIQKEKDIKEEKLSESK 1462

  Fly  1487 --SKARSKKTSASDNNGNKPMHFTANNEPRAL-EVLGDLDPSIFNECKEKMRPVKKALKALDQPD 1548
              .:.||||:|.||    .|:|.||:.||..: |...:||...|:.|||:|||||.|||.||:|:
Human  1463 SDGRERSKKSSVSD----APVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPE 1523

  Fly  1549 VSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAETEK-KEWRSNLWYFVSKFTELDAKRLFKIYKHA 1612
            ..||:::||:|||.||::||..|..||..|...|: |:||.|||.|||||||.||::|.|:||||
Human  1524 KGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA 1588

  Fly  1613 LKQKAGGDGEAKGKDKGSSGSPAKSKPNGV----------------------TTEEKEKERDRSG 1655
            :|::   ....:..|:.|:.:|...:...|                      .|:..:..:||..
Human  1589 IKKR---QESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDRHQ 1650

  Fly  1656 GKKKKKDKDKER------SGQ-----------ARYPETGIPTSGRYADPPLKRKRDEN-DADASS 1702
            |...||...::|      :|:           :||          |:|....||.|:: ..|..|
Human  1651 GDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRY----------YSDREKHRKLDDHRSRDHRS 1705

  Fly  1703 GLAGAPGGGIGDNLKSMSFKRLNMD-RHEDRKKHHRGP-DYYGGSGPPMGSGSYEGGSNSRRQGP 1765
            .|.|:.......:.:|.|..||:.| |......||:.. ||...|       .::....:...||
Human  1706 NLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHS-------DWQMDHRASSSGP 1763

  Fly  1766 TSPSTPRTGRGGYDP--PPAPSGYTPEMERWQSR 1797
            .||...|:..|...|  .......||| ..|.||
Human  1764 RSPLDQRSPYGSRSPFEHSVEHKSTPE-HTWSSR 1796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	27/47 (57%)
		Chromo	458..509	CDD:278797	24/51 (47%)
		SNF2_N	548..829	CDD:278600	202/280 (72%)
		DEXDc	564..709	CDD:238005	102/144 (71%)
		Helicase_C	852..967	CDD:278689	99/114 (87%)
		DUF4208	1521..1610	CDD:290618	50/89 (56%)
		DUF3824	1795..>1894	CDD:289625	2/3 (67%)
CHD1	NP_001351042.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..252		90/304 (30%)
		CHROMO	306..355	CDD:237991	29/51 (57%)
		Chromo	389..443	CDD:306815	24/53 (45%)
		SNF2_N	464..>1000	CDD:331286	391/541 (72%)
		DEAH box	614..617		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1080..1120		15/48 (31%)
		DUF4208	1496..1586	CDD:316429	50/89 (56%)
		DUF1777	1672..>1781	CDD:312240	29/125 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I687
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1486	1.000	Inparanoid score	I105
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54459
OrthoDB	1	1.010	-	-		D57339at2759
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		otm40787
orthoMCL	1	0.900	-	-		OOG6_102222
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R569
SonicParanoid	1	1.000	-	-		X1425
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870