Protein Alignment Chd1 and chd6

DIOPT Version :10

• Sequence 1: NP_001245851.1
• Gene: Chd1 / 33505
• FlyBaseID: FBgn0250786
• Length: 1900
• Species: Drosophila melanogaster
• Sequence 2: XP_004918574.2
• Gene: chd6 / 100498254
• XenbaseID: XB-GENE-5964535
• Length: 2667
• Species: Xenopus tropicalis
• Alignment Length: 1795
• Identity: 497/1795 - (27%)
• Similarity: 769/1795 - (42%)
• Gaps: 446/1795 - (24%)

  Fly     8 KPDKSKQFDPGCRALNESANSIGSDEQDDTREEANGTDHSGSGSGSGSSGSDSDS----DSSSGN 68
            |||:..   |..:||:.|..|..|..          .:|....|.|.|:..|..|    |::|..
 Frog     7 KPDQQL---PSLKALSYSPMSSASIP----------CEHPILPSFSESTPQDFHSVTLLDTTSHL 58

  Fly    69 SSDGRSSPEP-EDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQR 132
            ..|....|:. :::.|:|..           :..||.     ::|..|.:|.......:.|.:::
 Frog    59 LDDNVLYPDSGQEECLAVEA-----------TSINGM-----ENSGGGGTGVKKKRKKKEPGEEK 107

  Fly   133 NQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDY 197
                        :.||::.:|.....|..:.:..|:|                     ::.:|..
 Frog   108 ------------VAKPKKKKEPKKVKEPKKVKEPSEA---------------------KDPKEQK 139

  Fly   198 RPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKPAATTSR---SK 259
            :||..::.:||    .|.::...||.||...||               |.|.||...:..   :.
 Frog   140 QPKSPKEPKKP----RKPREPKPPKQKKANQDS---------------AAKTKPKKLSKEQGPTP 185

  Fly   260 LAQQQQRRRVKPFSSEDSDDD------------------DASKRCATRRKGAAVSYKEASEDEAT 306
            |.::::.:|...||.|..|.:                  |:.|    ||.|..|..::.:||
 Frog   186 LEKKKKGKRKAEFSEESLDGEPSLLNPASQSTEESTESLDSQK----RRSGRQVKRRKYNED--- 243

  Fly   307 DSEDLLEFEY--DESQ--------------AATTAATAEE--EEKCETIERILAQRAGKRGCTGN 353
                 |:|:.  |:.:              |:|.|..|||  |:....|||||:.|
 Frog   244 -----LDFKVVDDDGETIAVLGAGRASALSASTLAWQAEEPPEDDANIIERILSSR--------- 294

  Fly   354 QTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMK--AKGMKKL 416
                  |.:..| .|||.      ..|.| :|.:|::.:||:|..|   |||.:::  .:..:|:
 Frog   295 ------ISQKEF-MHAGI------PLEVE-EFYVKYRNFSYLHCKW---ATLEELEKDPRIQQKI 342

  Fly   417 DNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEE------Y 475
            ..|..|   ||..:......|.|.|.          ..|..|||::......|..|.|      :
 Frog   343 KRFRNK---QAQMKHIFTEPDEDMFN----------PDYVEVDRVLEVAHTKDSDTGEVREVTHF 394

  Fly   476 LCKWQSLPYAESTW---EDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRP---KFSRIKN 534
            |.||.||||.||||   ||...|..|.....::..|     .||..       ||   .:.::.:
 Frog   395 LVKWCSLPYEESTWELEEDVDPVKVKEFEALQKVPD-----LTPME-------RPASETWQKLVS 447

  Fly   535 QPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLC 599
            ...:.::. .||:||::|:||||.:|....:.|||||||||||||:|.||..:| ...:.||||.
 Frog   448 SRTYKNNN-QLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIF-FMGIRGPFLI 510

  Fly   600 VVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKR------LKFNCILTTYE 658
            :.||||:|.|:|||..|. :||.:.|.|...||::|.|||..:...:.      .||..::||:|
 Frog   511 IAPLSTITNWEREFRTWT-EMNTIVYHGSQISRQMIHQYEMYYRDEQGTPIPGIYKFQIVITTFE 574

  Fly   659 IVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHF 723
            ::|.|...|..::|:.:::||||||||.:..|.:.||.....|::|:||||||||::||::||:|
 Frog   575 MILADCPELKKIRWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELYSLLNF 639

  Fly   724 IMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQK 787
            :.|.:|.:...|..:.|:.: ::...:|...|:|.:|||:|.||||:|..|.|.|:.||:|::||
 Frog   640 LEPVQFPSESTFLEEFGDLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQK 704

  Fly   788 QYYKWILTKNFDALRKG-KRGSTSTFLNIVIELKKCCNHAALIRPSEFELM----------GLQQ 841
            :||:.||.|||..|.|| .:.:....:|.::||:|||||..||..:|.:::          .|
 Frog   705 KYYRAILEKNFTFLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKRHSPDAL-- 767

  Fly   842 DEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGE 906
            |..||.:::.:|||||:||||.:|...||:|||||||||.||:|.|||.:|.:.::|:||.::|.
 Frog   768 DFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYIYERIDGRVRGN 832

  Fly   907 MRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQ 971
            :|:.|:|.|....|..|.|||.||||||||||..|||.||||||||||||||||||.|||||...
 Frog   833 LRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKA 897

  Fly   972 VNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAIL 1036
            |.:|||:|..|.|.::.::|..|:.||..|:|.::..|.|      ||    ..|.:|.::..:|
 Frog   898 VKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGNT------NG----VQPLSKIEVEDLL 952

  Fly  1037 KFGAEELFKDEQEHDDDLVC--DIDEILRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSV 1099
            :.||.....|| |.:....|  |||:||:|   |.:...:.::...|.|..||..:.......|:
 Frog   953 RKGAYGALMDE-EDEGSKFCEEDIDQILQR---RTQTITIQSEGKGSTFAKASFVSSGNRTDISL 1013

  Fly  1100 SKQDQNAAGEEDDSKDWDDIIPEGFRKAID-DQERAKEMEDLYL--PPRRKTAANQNEGKRGAGK 1161
                       ||...|     :.:.|..: |.:...|.|.|.|  |..||...:.|..:
 Frog  1014 -----------DDPNFW-----QKWAKIAELDTDARNEKESLVLDRPRVRKQTKHYNSFE----- 1057

  Fly  1162 GGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLH 1226
                    ||...:.. ||.||         ...|||...::...|    ||::|:
 Frog  1058 --------DDELMEFS-ELESD---------TEERPTRSRRLNDKT----RRYLRA--------- 1091

  Fly  1227 RMEAIACDAEL------QEKPLAELKRLGEMLHDR------------CVQFLHEHKEEESKTAAT 1273
              |....:..|      :.|.:..|.|....|:::            ||:  |...:|:.|:...
 Frog  1092 --ECFRVEKNLLIFGWGRWKDILNLGRFKWHLNEKDMEMICRALLVYCVK--HYKGDEKIKSFIW 1152

  Fly  1274 D-------------------ETPGAKQRRARATFSVKLGGVSFNAKKLLACEQEL---------- 1309
            |                   ..|..:.|:.:...:..|.....||..|.:|..|:
 Frog  1153 DLITPTKDGHNQALQNHSGLSAPVPRGRKGKKLKNQMLLPEIKNADWLASCNPEIVLHDDSYKKH 1217

  Fly  1310 --QPLNEIMPSMPEERQQWSFNIK--------TRA-------------PVFD-----VD-WGIEE 1345
              |..|:::     .|.:..:.:|        :||             |..|     || |..|.
 Frog  1218 LKQHCNKVL-----LRVRMLYYLKAEVLGEAASRALEGENARDLEVLLPDIDYVEIPVDWWDTEA 1277

  Fly  1346 DTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGG 1410
            |..||.|:|::|...:..|:.||.|...||:.:.|.....|..:...|.          ||..|.
 Frog  1278 DKSLLLGVYKHGYERYFAMRADPALCFLDKVGMPDETSLTADGVNDVAP----------ELGDGS 1332

  Fly  1411 QRRQRRPRASRANDAKAASQSASSTIDAKPHDG-EDAAGDARTVAESSNSQVDPSTASPHNAPAT 1474
            ..::..      |:.|...|..    ||....| |:.|.:..::.|:..:|         ::|..
 Frog  1333 AIKEEN------NEEKVNEQQE----DASESTGKEEKADEESSIVENIQAQ---------DSPEA 1378

  Fly  1475 EQHGDPAKKAKKSKARSKKTSASDNNGN---KPMHFTANNEPRALEV----LGDLDPSIFNECKE 1532
            ::...|...|..::.|...|.....|..   :|......|....|:.    ..::|| |..|.::
 Frog  1379 DKLSWPVASALTARLRRLITVYQRCNRRDLARPEVLVPTNHSYWLQEEMARRAEMDP-IMKEMQK 1442

  Fly  1533 KMRPVKKA--------LKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAET-------- 1581
            :....::|        ...:..|:....|..|.:    .|.::.|:.|..|..|..:
 Frog  1443 RWTRREQADFYRTVSSFGVIYDPEKKCFDWTQFR----ALSRLDKKTDESLEKYFHSFVAMCRNV 1503

  Fly  1582 -----EKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQK 1616
                 .|.:..::...|:...||..|.|  .:|:..|.:|
 Frog  1504 CRLPLRKDDGSADPSLFLDPITEERAAR--TLYRIELLRK 1541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CD1_tandem_CHD1-2_like	339..421	CDD:349313	22/83 (27%)
		CD2_tandem	454..508	CDD:349306	22/62 (35%)
		PLN03142	531..>1066	CDD:215601	244/554 (44%)
		CDH1_2_SANT_HL1	1205..1298	CDD:465731	19/129 (15%)
		DUF4208	1521..1610	CDD:464035	19/109 (17%)
chd6	XP_004918574.2	CD1_tandem_CHD5-9_like	281..347	CDD:349315	25/91 (27%)
		CD2_tandem_CHD5-9_like	366..426	CDD:349310	22/59 (37%)
		PLN03142	456..>981	CDD:215601	243/539 (45%)
		DEXHc_CHD6	457..678	CDD:350816	94/222 (42%)