Protein Alignment Chd1 and chd2

DIOPT Version :9

• Sequence 1: NP_001245851.1
• Gene: Chd1 / 33505
• FlyBaseID: FBgn0250786
• Length: 1900
• Species: Drosophila melanogaster
• Sequence 2: XP_002933353.2
• Gene: chd2 / 100497210
• XenbaseID: XB-GENE-950755
• Length: 1809
• Species: Xenopus tropicalis
• Alignment Length: 1954
• Identity: 899/1954 - (46%)
• Similarity: 1180/1954 - (60%)
• Gaps: 266/1954 - (13%)

  Fly    50 GSGSGSSGSDSDSDSSSGNSSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSD 114
            |...||:.|::.|.|:|            |:.:.||.|   :.:|:|::|: :......|.:||.
 Frog     9 GEEDGSAHSNASSHSAS------------EESNHSVYG---SESASQSESE-HVTEQGSESNSSS 57

  Fly   115 GSSGSDSDSDAEGPSDQRNQSINNANTSSSLPKPEQ--------NEEED----NETEAGQQQPAS 167
            .||.|.|:||.|....:.:.::..:. ...|||.|:        .|..|    ..:...:|:|:.
 Frog    58 ESSESHSESDCESTGSKTHDALAESK-EKPLPKKERLADVKKMWEEYPDVYGVRRSNRSRQEPSR 121

  Fly   168 DASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDE 232
            .....|||||               |.|..|.:..|..||                |:|...||:
 Frog   122 FNIKAESSDS---------------ESESPRRRSMRSTRK----------------KEKNIVSDD 155

  Fly   233 SDE---SEDSDDE-----VSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSE------DSDDDDAS 283
            .||   |.:||.|     .|..|:::..|.:|.:||.:..:.::.|..|||      |.||||.:
 Frog   156 EDEEGSSAESDAEQTKFRSSRLQQKRKLAKSSTNKLKRSLRGKKRKQASSEEEDDDDDDDDDDET 220

  Fly   284 KRCATRRKGAA-VSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGK 347
            .:..|||:.|. ||||| .:|..|||:||:|...:|::        |.|:..||||::|..|.||
 Frog   221 PKRQTRRRAAKNVSYKE-DDDFETDSDDLIEMVGEEAE--------ELEDSHETIEKVLDSRIGK 276

  Fly   348 RGCTGNQTTIYAIEENGFDPHAGFDEKQTPDA-ETEAQFLIKWKGWSYIHNTWESEATLRDMKAK 411
            :|..|..||:||.|||| ||::.|:    |:. |.|.|:|||||||||||.|||||.:|:..|.|
 Frog   277 KGAIGASTTVYATEENG-DPNSEFN----PETDEREQQYLIKWKGWSYIHGTWESEDSLQQQKVK 336

  Fly   412 GMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIA-KGSKPDDG---- 471
            |:|||:||.|||:|...|.....|||::||.||.||..||.|.|..|:|:|| |.||...|
 Frog   337 GLKKLENFKKKEEEIKQWLSKVSPEDVEYFSCQQELASELNKQYQIVERVIAVKTSKSSSGHSDF 401

  Fly   472 -----------TEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKY 525
                       ..||||||..|||:|.:|||.|||.:|:|.|.:.||.|.:||.||.:.|:|::.
 Frog   402 PVHSRKTSSSNEPEYLCKWMGLPYSECSWEDGALVGKKFQHCIDSFNCRNNSKTTPVKDCKVLRQ 466

  Fly   526 RPKFSRIKNQPEFL-SSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFK 589
            ||:|..:|.||.:: ..||.|||||::|||||.|||||.||||||||||||||||||.||..||.
 Frog   467 RPRFVTLKKQPSYIGGEGLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFH 531

  Fly   590 IHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCIL 654
            :|.||||||.||||||:|:|||||::||||:|||.|:||:.||..|::|||..:.||::|||.:|
 Frog   532 LHLLYGPFLLVVPLSTLTSWQREFEVWAPDINVVVYIGDLGSRNTIREYEWVHQQSKKMKFNALL 596

  Fly   655 TTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWA 719
            |||||:||||..|.::.||.|.||||||||||||||||:|.||.:|.|||||||||||||||||:
 Frog   597 TTYEILLKDKAVLSSINWAFLGVDEAHRLKNDDSLLYKTLIEFKSNARLLITGTPLQNSLKELWS 661

  Fly   720 LLHFIMPDKFDTWENFEVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTS 784
            |||||||:||:.||:||.|||...|.||..||:.|||::||||||||||||||||||||||||..
 Frog   662 LLHFIMPEKFECWEDFEDQHGKGRDNGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMCV 726

  Fly   785 LQKQYYKWILTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAALIRPSEFELMGLQQDEALQTLL 849
            :|||||:||||:|:.||.||.|||||.|||||:||||||||..||:|.|.|..  .:.::||:|:
 Frog   727 MQKQYYRWILTRNYKALSKGTRGSTSGFLNIVMELKKCCNHCFLIKPEETEKE--SRLDSLQSLI 789

  Fly   850 KGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDH 914
            :.|||||||||||.||:|.|:|||||||||||||:||:||..:|:||||||||||||:|:|||||
 Frog   790 RSSGKLVLLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLAIKHYPFQRLDGSIKGELRKQALDH 854

  Fly   915 FNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVT 979
            ||||||:||||||||||||||||||:||||:||||||||||||||||||||||||.|||||||||
 Frog   855 FNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVT 919

  Fly   980 ARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELF 1044
            ..:|||.|:||||:|||||||||||||||||||||  .|..|||.||||||:|:|||||||.:||
 Frog   920 RGTVEEDIIERAKKKMVLDHLVIQRMDTTGRTVLD--NNSGSSNCNPFNKDELAAILKFGAADLF 982

  Fly  1045 KD-EQEHDDDLVCDIDEILRRAETRNEDPEMPA-DDLLSAFKVASIAAFEEEPSDSVSKQDQNAA 1107
            |: |.|..:....|||||||.||||..:|...| |:|||.||||:.|..|||| :.|.|::|
 Frog   983 KETEGEELEPQEMDIDEILRLAETRENEPSSSATDELLSQFKVANFATMEEEP-EMVLKREQ--- 1043

  Fly  1108 GEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPPR-----RKTAANQNEGKRGAGKGGKGKQ 1167
                   :||||||||.||.::::.|.||::::|:.||     :|..||.:|...      :.||
 Frog  1044 -------EWDDIIPEGQRKKVEEEARQKELQEIYMLPRIRSLNKKPQANDSESDL------ESKQ 1095

  Fly  1168 QAD-DSGGDSDYELGSDGSGDDGRPRKRGRP--TMKEKITGFTDAELRRFIRSYKKFPAPLHRME 1229
            :|. .||.:||    ||.|.||.:|::||||  ..|:.:.||||||:||||::||||.:||.|:|
 Frog  1096 KAQRSSGSESD----SDDSDDDKKPKRRGRPRSVRKDNVEGFTDAEIRRFIKAYKKFASPLERLE 1156

  Fly  1230 AIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGG 1294
            .||.||||.||.:|:||||||:||:.|...:.|.:|:..:..|..:.||  :||..   ::|:.|
 Frog  1157 CIARDAELVEKSVADLKRLGELLHNSCASAMQEFEEQLKENPADGKGPG--KRRGP---TIKISG 1216

  Fly  1295 VSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIG 1359
            |..|.|.::..|::.:.|::.:|:.|||:::::...:.:|..|||:|.||:|:.||.|||::|.|
 Frog  1217 VQVNVKAIIQHEEDFEVLSKSIPADPEEKKKFNVVSRVKAAHFDVEWAIEDDSHLLLGIYEHGYG 1281

  Fly  1360 SWEQMKLDPTLKLTDKILLNDT-RKPQAKQLQTRAEYLLKIIKKNVELTKGG----QRRQRRPRA 1419
            :||.:|.||.|||::|||..|| :|||||.|||||:||||::||.:|...|.    :.::|:|||
 Frog  1282 NWEHIKSDPELKLSEKILPVDTEKKPQAKHLQTRADYLLKMLKKEMEKETGAAEEPKSKKRKPRA 1346

  Fly  1420 SRANDAKAASQSASSTIDAKPHDGEDAAGDARTVAESSNS----QVDPSTASPHNAPATEQHGD- 1479
            .: :..|...:..:.....:..|.....|:.:......|:    |.........:....::.||
 Frog  1347 KK-DSGKTKDEHGNDISSPRHSDNNSEEGEEKEDGTEKNTNKKKQKKKDNKENKDKQTQKKEGDK 1410

  Fly  1480 PAKKAKKSKARSKKTSASDNNGNK----PMHFTANNEPRAL--EVLGDLDPSIFNECKEKMRPVK 1538
            ..||||..|.::|:..|.....|:    |:|.||.:||..:  |...|||...|:.|||:|||||
 Frog  1411 DKKKAKDKKEKAKRGEAKPGGKNRKNQGPVHITAGSEPVPIGEEEEDDLDQETFSICKERMRPVK 1475

  Fly  1539 KALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAETEK-KEWRSNLWYFVSKFTELDA 1602
            ||||.||..|..||.|:||:|||.|||:||.:|..||..|::.|. |.||.|||.|||||||.||
 Frog  1476 KALKQLDNADKGLSVQEQLEHTRTCLLKIGDRISECLKMYSDQEHVKLWRRNLWIFVSKFTEFDA 1540

  Fly  1603 KRLFKIYKHALKQKAGGDGEAKGKD-----------KGSSGSPAKSKPNGVTTEEK--------- 1647
            ::|.|:||.|.|:::..:.:.|.||           .|||..|..|:..|..|.:|
 Frog  1541 RKLHKLYKMAHKKRSQEEEDHKKKDVSVKKPFRPEQSGSSRDPHVSQSQGPHTPQKPVIVPPHTQ 1605

  Fly  1648 ---EKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGLAGAPG 1709
               ..:|:..|...|:...:.||              |.:.|    ||.:....:::.     |.
 Frog  1606 QVHSHQRENFGSPNKRPFNNAER--------------GEWRD----RKFNYGGNNSNQ-----PW 1647

  Fly  1710 GGIGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSGPPMG-----SGSYEGGSNSRRQGPTSPS 1769
            ||               |||. :...||..|::.....|.|     |.::...:.||::.....:
 Frog  1648 GG---------------DRHH-QYDQHRYKDHHYSERRPHGDPRRSSANFRPNNMSRKRPYDQYN 1696

  Fly  1770 TPRTGRGGYDPPPAPSGYTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQGSYHRERDRR-PEKR 1833
            ..|..||..|                ..||:..|.||.|.|.:...     |||::..|| ....
 Frog  1697 NDRDHRGHRD----------------YYDRHHHDNKRRRSDDFRPQ-----SYHQQDFRRMGSDH 1740

  Fly  1834 RYPSGLPPHPYSSHYLPPNYYGLPNGAVPGLPPPSSVYRSDPRGYPVM--------PRDYPADYR 1890
            |.|.|......|.||  .:::...:|...|  |..|...||||..|..        |.|...:.:
 Frog  1741 RPPMGYHSQGPSDHY--RSFHSEKSGDYKG--PSQSTSLSDPRSPPTQRSPHDNKPPLDRSLEQK 1801

  Fly  1891 RSDY 1894
            ..||
 Frog  1802 SGDY 1805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	29/48 (60%)
		Chromo	458..509	CDD:278797	29/66 (44%)
		SNF2_N	548..829	CDD:278600	205/280 (73%)
		DEXDc	564..709	CDD:238005	102/144 (71%)
		Helicase_C	852..967	CDD:278689	99/114 (87%)
		DUF4208	1521..1610	CDD:290618	54/89 (61%)
		DUF3824	1795..>1894	CDD:289625	29/107 (27%)
chd2	XP_002933353.2	CD1_tandem_CHD1-2_like	264..346	CDD:349313	50/86 (58%)
		CD2_tandem_CHD1-2_like	379..450	CDD:349308	30/70 (43%)
		DEXHc_CHD2	467..703	CDD:350812	161/235 (69%)
		PLN03142	471..>1005	CDD:215601	392/537 (73%)
		CDH1_2_SANT_HL1	1132..1220	CDD:408175	46/92 (50%)
		DUF4208	1466..1548	CDD:404744	50/81 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	408	1.000	Domainoid score	I686
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37462
Inparanoid	1	1.050	1482	1.000	Inparanoid score	I107
OMA	1	1.010	-	-		QHG54459
OrthoDB	1	1.010	-	-		D57339at2759
OrthoFinder	1	1.000	-	-		FOG0002141
OrthoInspector	1	1.000	-	-		otm47975
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1425
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080