DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp1 and SRP40

DIOPT Version :9

Sequence 1:	NP_001137776.1	Gene:	Rrp1 / 33500	FlyBaseID:	FBgn0004584	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_013018.3	Gene:	SRP40 / 853967	SGDID:	S000001800	Length:	406	Species:	Saccharomyces cerevisiae

Alignment Length:	421	Identity:	68/421 - (16%)
Similarity:	167/421 - (39%)	Gaps:	56/421 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRVKAVKKQAEALASEPTDPTPNANGNGVDENADSAAEELKVPAKGKPRARKATKTAVSAENSE 65
            :|::...:|:.|..:|..:..:.:::.:....::.|:       :.|:..:..::.::.|:.:|.
Yeast    11 VPKLSVKEKEIEEKSSSSSSSSSSSSSSSSSSSSSSS-------SSGESSSSSSSSSSSSSSDSS 68

  Fly    66 EVEPQKAPTAAARGKKKQPKDTDENGQMEVVAKPKGRAKKAT---------AEAEPEPK-----V 116
            :....::.::::.........:|.....|..:...|.:..::         :|:|.|.|     .
Yeast    69 DSSDSESSSSSSSSSSSSSSSSDSESSSESDSSSSGSSSSSSSSSDESSSESESEDETKKRARES 133

  Fly   117 DLPAGKATKPRAKKEP-TPAPDEVTSSPPKGRAKAEKPTNAQAKGRKRKELPAEANGGAEEAAEP 180
            |....|.|| :||.|| :.:..|.:||.....:::|..:.:.:.........:::...:|..::.
Yeast   134 DNEDAKETK-KAKTEPESSSSSESSSSGSSSSSESESGSESDSDSSSSSSSSSDSESDSESDSQS 197

  Fly   181 PKQRARKEAVPTLKEQAEPGTISKEKVQKAETAAKRARGTKRLADSEIAAALDEPEVDEVPPKAA 245
            ....:..::      .::..:.|.:....:::::..:..:.. :||:..::.|..........::
Yeast   198 SSSSSSSDS------SSDSDSSSSDSSSDSDSSSSSSSSSSD-SDSDSDSSSDSDSSGSSDSSSS 255

  Fly   246 SKRAKKGKMVEPSPETVGDFQS-VQEEVESPPKTAAAPKKRAKKT--TNGETAVELEPKTKAK-- 305
            |..:........|.::..|..| ...|:|:  |.|.|.:.:|::|  ::.|:.......:.|.
Yeast   256 SDSSSDESTSSDSSDSDSDSDSGSSSELET--KEATADESKAEETPASSNESTPSASSSSSANKL 318

  Fly   306 --PTKQRAKKEGKEPAPGKKQKKSADKENGVVEEEAKPSTET--KPAKGR--KKAPVKAEDVEDI 364
              |......|||:     :|.....|:..  :..||...|:.  |.|.|.  :||..|...|...
Yeast   319 NIPAGTDEIKEGQ-----RKHFSRVDRSK--INFEAWELTDNTYKGAAGTWGEKANEKLGRVRGK 376

  Fly   365 EEAAEESKPARGRKKAAAKAEEPDVDEESGS 395
            :....::|..||..:..:      :..||||
Yeast   377 DFTKNKNKMKRGSYRGGS------ITLESGS 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp1	NP_001137776.1	RecX	15..>217	CDD:294607	26/216 (12%)
		RR_TM4-6	<314..>388	CDD:283990	17/77 (22%)
		Ape1-like_AP-endo	454..704	CDD:197321
SRP40	NP_013018.3	SRP40_C	334..404	CDD:398615	18/76 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2992
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900