DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp1 and Apex1

DIOPT Version :9

Sequence 1:	NP_001137776.1	Gene:	Rrp1 / 33500	FlyBaseID:	FBgn0004584	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_077062.1	Gene:	Apex1 / 79116	RGDID:	2126	Length:	317	Species:	Rattus norvegicus

Alignment Length:	350	Identity:	164/350 - (46%)
Similarity:	210/350 - (60%)	Gaps:	56/350 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 PARGRKKAAAKAEEPDVDEESGSKSMLAEQSGCGGAAVLKSLQTMLNFCFPATKKAKKAETKTTV 437
            |.||::.||...|||..:                                |.|||:|.|..||
  Rat     2 PKRGKRAAAEDGEEPKSE--------------------------------PETKKSKGAAKKT-- 32

  Fly   438 TLDKDA-------FALPAD-------KEFNLKICSWNVAGLRAWLKKDGLQLIDLEEPDIFCLQE 488
              :|:|       :..|.|       |...||||||||.|||||:||.||..:..|.|||.||||
  Rat    33 --EKEAAGEGPVLYEDPPDQKTSASGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQE 95

  Fly   489 TKCANDQLPEEVTRLPGY-HPYWLCMPG---GYAGVAIYSKIMPIHVEYGIGNEEFDDVGRMITA 549
            |||:.::||.|:..|||. |.|| ..|.   ||:||.:.|:..|:.|.||||.||.|..||:|.|
  Rat    96 TKCSENKLPAELQELPGLTHQYW-SAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVA 159

  Fly   550 EYEKFYLINVYVPNSGRKLVNLEPRMRWEKLFQAYVKKLDALKPVVICGDMNVSHMPIDLENPKN 614
            |:|.|.|:..||||:||.||.||.|.||::.|:.::|.|.:.||:|:|||:||:|..|||.|||.
  Rat   160 EFESFILVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKG 224

  Fly   615 NTKNAGFTQEERDKMTELL-GLGFVDTFRHLYPDRKGAYTFWTYMANARARNVGWRLDYCLVSER 678
            |.||||||.:||....|:| .:...|:||||||:...||||||||.|||::||||||||.|:|..
  Rat   225 NKKNAGFTPQERQGFGEMLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHS 289

  Fly   679 FVPKVVEHEIRSQCLGSDHCPITIF 703
            .:|.:.:.:|||:.|||||||||::
  Rat   290 LLPALCDSKIRSKALGSDHCPITLY 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp1	NP_001137776.1	RecX	15..>217	CDD:294607
		RR_TM4-6	<314..>388	CDD:283990	7/14 (50%)
		Ape1-like_AP-endo	454..704	CDD:197321	143/254 (56%)
Apex1	NP_077062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		20/90 (22%)
		Necessary for interaction with YBX1, binding to RNA, association together with NPM1 to rRNA, endoribonuclease activity on abasic RNA and localization in the nucleoli. /evidence=ECO:0000250	1..32		14/61 (23%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	8..12		2/3 (67%)
		Necessary for interaction with NPM1 and for efficient rRNA binding. /evidence=ECO:0000250	22..32		5/9 (56%)
		Ape1-like_AP-endo	61..315	CDD:197321	143/254 (56%)
		Nuclear export signal (NES). /evidence=ECO:0000250	63..79		13/15 (87%)
		Mitochondrial targeting sequence (MTS). /evidence=ECO:0000250	288..317		13/26 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344241
Domainoid	1	1.000	278	1.000	Domainoid score	I1630
eggNOG	1	0.900	-	-		E1_COG0708
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005771
OrthoInspector	1	1.000	-	-		oto97490
orthoMCL	1	0.900	-	-		OOG6_101139
Panther	1	1.100	-	-	LDO	PTHR22748
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5491
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.700